2019年轻度和无症状冠状病毒病(COVID-19)一年后严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)血清学敏感性的趋势:消除血清阳性率研究中的潜在偏差

Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America Pub Date : 2022-08-24 DOI:10.1093/cid/ciac020

Christopher R Bailie, Yeu Yang Tseng, Louise Carolan, Martyn D Kirk, Suellen Nicholson, Annette Fox, Sheena G Sullivan

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引用次数: 6

摘要

在2019冠状病毒病(COVID-19)大流行期间，血清监测的一个关键目的是通过根据聚合酶链反应(PCR)确认的COVID-19的估计检测性能校正粗血清阳性率，来估计先前感染的患病率。我们表明，敏感性估计对某些目标人群的泛化性差可能导致病例数的严重低估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Trend in Sensitivity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Serology One Year After Mild and Asymptomatic Coronavirus Disease 2019 (COVID-19): Unpacking Potential Bias in Seroprevalence Studies.

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A key aim of serosurveillance during the coronavirus disease 2019 (COVID-19) pandemic has been to estimate the prevalence of prior infection, by correcting crude seroprevalence against estimated test performance for polymerase chain reaction (PCR)-confirmed COVID-19. We show that poor generalizability of sensitivity estimates to some target populations may lead to substantial underestimation of case numbers.

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Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

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