sgk1调控的代谢:细胞脱离细胞外基质存活的关键。

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2021-09-24 eCollection Date: 2021-01-01 DOI:10.1080/23723556.2021.1976583

Jordan A Cockfield, Zachary T Schafer

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引用次数: 2

摘要

缺乏对细胞外基质(ECM)的附着的细胞经历代谢缺陷，可导致不依赖半胱天冬酶的细胞死亡。最近，我们发现血清和糖皮质激素激酶-1 (SGK1)在调节葡萄糖代谢、促进能量产生并最终促进ecm分离细胞的存活中起着关键作用。缩写:ECM，细胞外基质;SGK1，血清和糖皮质激素激酶1;ROS，活性氧;CCCP:氰化间氯苯肼;PPP，戊糖磷酸途径;G3P glyceraldhyde-3-phosphate;shRNA，短发夹RNA;TCA，三羧酸。

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SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix.

Cells that lack attachment to the extracellular matrix (ECM) experience metabolic defects that can lead to caspase-independent cell death. Recently, we discovered that serum and glucocorticoid kinase-1 (SGK1) plays a critical role in the regulation of glucose metabolism, the promotion of energy production, and ultimately the survival of ECM-detached cells. Abbreviations: ECM, extracellular matrix; SGK1, serum and glucocorticoid kinase-1; ROS, reactive oxygen species; CCCP, cyanide m-chlorophenyl hydrazine; PPP, pentose phosphate pathway; G3P, glyceraldhyde-3-phosphate; shRNA, short hairpin RNA; TCA, tricarboxylic acid.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.