miR-938rs2505901 T>C多态性增加先天性巨结肠疾病风险:一项中国儿童病例对照研究

IF 1.7 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Personalized medicine Pub Date : 2021-09-01 Epub Date: 2021-11-11 DOI:10.2217/pme-2021-0001
Jun Zhong, Jiabin Liu, Yi Zheng, Xiaoli Xie, Qiuming He, Wei Zhong, Qiang Wu
{"title":"miR-938rs2505901 T>C多态性增加先天性巨结肠疾病风险:一项中国儿童病例对照研究","authors":"Jun Zhong,&nbsp;Jiabin Liu,&nbsp;Yi Zheng,&nbsp;Xiaoli Xie,&nbsp;Qiuming He,&nbsp;Wei Zhong,&nbsp;Qiang Wu","doi":"10.2217/pme-2021-0001","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> To explore the association between <i>miR-938</i><i>rs2505901</i> T>C polymorphism and Hirschsprung disease (HSCR) risk in Chinese children. <b>Materials & Methods:</b> We conducted a case-control study in a Chinese population with 1381 cases and 1457 controls. The associated correlation strengths were assessed by adjusted odds ratios (AORs) and 95% CIs. <b>Results:</b> The results revealed that the <i>rs2505901</i> TC and <i>rs2505901</i> TC/CC genotype were related to an increased HSCR risk compared to the risk contributed by the <i>rs2505901</i> TT genotype. A stratification analysis showed that the <i>rs2505901</i> TC/CC genotype promoted the progression of HSCR more significantly in patients with the short-segment HSCR subtype. <b>Conclusion:</b> Our study indicated that <i>miR-938</i><i>rs2505901</i> T>C polymorphism is significantly associated with HSCR risk in Chinese children. This result needs to be confirmed with well-designed studies.</p>","PeriodicalId":19753,"journal":{"name":"Personalized medicine","volume":"18 6","pages":"551-558"},"PeriodicalIF":1.7000,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"<i>miR-938</i><i>rs2505901</i> T>C polymorphism increases Hirschsprung disease risk: a case-control study of Chinese children.\",\"authors\":\"Jun Zhong,&nbsp;Jiabin Liu,&nbsp;Yi Zheng,&nbsp;Xiaoli Xie,&nbsp;Qiuming He,&nbsp;Wei Zhong,&nbsp;Qiang Wu\",\"doi\":\"10.2217/pme-2021-0001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Aim:</b> To explore the association between <i>miR-938</i><i>rs2505901</i> T>C polymorphism and Hirschsprung disease (HSCR) risk in Chinese children. <b>Materials & Methods:</b> We conducted a case-control study in a Chinese population with 1381 cases and 1457 controls. The associated correlation strengths were assessed by adjusted odds ratios (AORs) and 95% CIs. <b>Results:</b> The results revealed that the <i>rs2505901</i> TC and <i>rs2505901</i> TC/CC genotype were related to an increased HSCR risk compared to the risk contributed by the <i>rs2505901</i> TT genotype. A stratification analysis showed that the <i>rs2505901</i> TC/CC genotype promoted the progression of HSCR more significantly in patients with the short-segment HSCR subtype. <b>Conclusion:</b> Our study indicated that <i>miR-938</i><i>rs2505901</i> T>C polymorphism is significantly associated with HSCR risk in Chinese children. This result needs to be confirmed with well-designed studies.</p>\",\"PeriodicalId\":19753,\"journal\":{\"name\":\"Personalized medicine\",\"volume\":\"18 6\",\"pages\":\"551-558\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2021-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Personalized medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2217/pme-2021-0001\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/11/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Personalized medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2217/pme-2021-0001","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/11/11 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 1

摘要

目的:探讨miR-938rs2505901 T>C多态性与中国儿童先天性巨结肠病(HSCR)风险的关系。材料与方法:我们在中国人群中进行了一项病例对照研究,共有1381例病例和1457例对照。通过校正优势比(AORs)和95% ci评估相关强度。结果:结果显示,与rs2505901 TT基因型相比,rs2505901 TC和rs2505901 TC/CC基因型与HSCR风险增加相关。分层分析显示,rs2505901 TC/CC基因型在短段HSCR亚型患者中更显著地促进HSCR的进展。结论:我们的研究表明miR-938rs2505901 T>C多态性与中国儿童HSCR风险显著相关。这一结果需要通过精心设计的研究来证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
miR-938rs2505901 T>C polymorphism increases Hirschsprung disease risk: a case-control study of Chinese children.

Aim: To explore the association between miR-938rs2505901 T>C polymorphism and Hirschsprung disease (HSCR) risk in Chinese children. Materials & Methods: We conducted a case-control study in a Chinese population with 1381 cases and 1457 controls. The associated correlation strengths were assessed by adjusted odds ratios (AORs) and 95% CIs. Results: The results revealed that the rs2505901 TC and rs2505901 TC/CC genotype were related to an increased HSCR risk compared to the risk contributed by the rs2505901 TT genotype. A stratification analysis showed that the rs2505901 TC/CC genotype promoted the progression of HSCR more significantly in patients with the short-segment HSCR subtype. Conclusion: Our study indicated that miR-938rs2505901 T>C polymorphism is significantly associated with HSCR risk in Chinese children. This result needs to be confirmed with well-designed studies.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Personalized medicine
Personalized medicine 医学-药学
CiteScore
3.30
自引率
4.30%
发文量
49
审稿时长
6-12 weeks
期刊介绍: Personalized Medicine (ISSN 1741-0541) translates recent genomic, genetic and proteomic advances into the clinical context. The journal provides an integrated forum for all players involved - academic and clinical researchers, pharmaceutical companies, regulatory authorities, healthcare management organizations, patient organizations and others in the healthcare community. Personalized Medicine assists these parties to shape thefuture of medicine by providing a platform for expert commentary and analysis. The journal addresses scientific, commercial and policy issues in the field of precision medicine and includes news and views, current awareness regarding new biomarkers, concise commentary and analysis, reports from the conference circuit and full review articles.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信