Ahmed Seri, Hala Kamal Ali Mohamed, Mohammed Elmujtba Adam Essa, Elnour Mohammed Elagib, Noha Ibrahim Ahmed Eltahirm, Salma Mohammed Alfatih Mansour, Abdelkareem A Ahmed
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Conducted with 60 patients with RA, data were collected through a designated questionnaire which included demographic, age, gender, duration of the disease, laboratory finding. All the patients in the study were treated with conventional DMARDs and diagnosed according to the 2010 ACR/EULAR criteria; their disease activity status was assessed by DAS28/ESR. Data were analyzed using SPSS version 23.</p><p><strong>Results: </strong>The study found that 91.7% of the patients were females, patients of age group between 36 and 50 years had the highest percentage at 38.3% followed by those between 51 and 70 years and the least age group between 20 and 35 years, 36.7% and 15%, respectively. Of all the patients 61.7% were found to be SPRA, while the remaining 38.3% were seronegative (SNRA). Altogether 55% of the patients had moderate disease activity, followed by 16.7% who had a remission, 15% had high disease activity and the remaining 13.3% had low disease activity. The metacarpophalangeal (MCP) joint was found to be the only joint that was significantly associated with DAS28 and its involvement was greater among seropositive patients. The most affected joints were found to be shoulders, knees, wrist, MCP, PIP and elbow, in that order.</p><p><strong>Conclusion: </strong>Females, middle-age group and shoulder joint were the most affected. Most RA was found to be SPRA, and the seropositive group was found to be more associated with high disease activity, while the seronegative group was associated with remission and low disease activity.</p>","PeriodicalId":45545,"journal":{"name":"Open Access Rheumatology-Research and Reviews","volume":"13 ","pages":"325-332"},"PeriodicalIF":1.7000,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/84/13/oarrr-13-325.PMC8643210.pdf","citationCount":"1","resultStr":"{\"title\":\"Analysis of Serum Immune Markers in Seropositive and Seronegative Rheumatoid Arthritis Among Sudanese Patients and the Relation Between the Serotype and Joint Involvement: A Cohort Study.\",\"authors\":\"Ahmed Seri, Hala Kamal Ali Mohamed, Mohammed Elmujtba Adam Essa, Elnour Mohammed Elagib, Noha Ibrahim Ahmed Eltahirm, Salma Mohammed Alfatih Mansour, Abdelkareem A Ahmed\",\"doi\":\"10.2147/OARRR.S339134\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovial membrane. RA is classified as seropositive or seronegative, according to the absence or presence of primarily IgM RF, RF, and/or ACPA. The aim of this study is to identify the relationship between the serotype of rheumatoid arthritis and the level of ESR.</p><p><strong>Methods and materials: </strong>This is a descriptive, cross-sectional study done in Omdurman military hospital, Khartoum, Sudan. Conducted with 60 patients with RA, data were collected through a designated questionnaire which included demographic, age, gender, duration of the disease, laboratory finding. All the patients in the study were treated with conventional DMARDs and diagnosed according to the 2010 ACR/EULAR criteria; their disease activity status was assessed by DAS28/ESR. Data were analyzed using SPSS version 23.</p><p><strong>Results: </strong>The study found that 91.7% of the patients were females, patients of age group between 36 and 50 years had the highest percentage at 38.3% followed by those between 51 and 70 years and the least age group between 20 and 35 years, 36.7% and 15%, respectively. Of all the patients 61.7% were found to be SPRA, while the remaining 38.3% were seronegative (SNRA). Altogether 55% of the patients had moderate disease activity, followed by 16.7% who had a remission, 15% had high disease activity and the remaining 13.3% had low disease activity. The metacarpophalangeal (MCP) joint was found to be the only joint that was significantly associated with DAS28 and its involvement was greater among seropositive patients. The most affected joints were found to be shoulders, knees, wrist, MCP, PIP and elbow, in that order.</p><p><strong>Conclusion: </strong>Females, middle-age group and shoulder joint were the most affected. 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引用次数: 1
摘要
类风湿关节炎(RA)是一种以滑膜炎症为特征的慢性自身免疫性疾病。根据主要IgM、RF、RF和/或ACPA是否存在，RA分为血清阳性或血清阴性。本研究的目的是确定类风湿关节炎血清型与ESR水平之间的关系。方法和材料:这是在苏丹喀土穆的恩图曼军事医院进行的一项描述性横断面研究。对60名RA患者进行研究，通过指定的问卷收集数据，包括人口统计、年龄、性别、疾病持续时间、实验室结果。研究中所有患者均接受常规dmard治疗，并根据2010年ACR/EULAR标准进行诊断;采用DAS28/ESR评估其疾病活动状态。数据分析采用SPSS version 23。结果:研究发现，女性占91.7%，36 ~ 50岁患者比例最高，为38.3%，51 ~ 70岁患者比例次之，20 ~ 35岁患者比例最低，分别为36.7%和15%。SPRA阳性率为61.7%，SNRA阳性率为38.3%。总共55%的患者有中度疾病活动性，其次是16.7%的患者有缓解，15%的患者有高疾病活动性，其余13.3%的患者有低疾病活动性。发现掌指关节(MCP)是唯一与DAS28显著相关的关节，其累及程度在血清阳性患者中更大。受影响最大的关节依次是肩膀、膝盖、手腕、MCP、PIP和肘关节。结论:以女性、中年人和肩关节为主。大多数RA被发现为SPRA，血清阳性组与高疾病活动性相关，而血清阴性组与缓解和低疾病活动性相关。
Analysis of Serum Immune Markers in Seropositive and Seronegative Rheumatoid Arthritis Among Sudanese Patients and the Relation Between the Serotype and Joint Involvement: A Cohort Study.
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovial membrane. RA is classified as seropositive or seronegative, according to the absence or presence of primarily IgM RF, RF, and/or ACPA. The aim of this study is to identify the relationship between the serotype of rheumatoid arthritis and the level of ESR.
Methods and materials: This is a descriptive, cross-sectional study done in Omdurman military hospital, Khartoum, Sudan. Conducted with 60 patients with RA, data were collected through a designated questionnaire which included demographic, age, gender, duration of the disease, laboratory finding. All the patients in the study were treated with conventional DMARDs and diagnosed according to the 2010 ACR/EULAR criteria; their disease activity status was assessed by DAS28/ESR. Data were analyzed using SPSS version 23.
Results: The study found that 91.7% of the patients were females, patients of age group between 36 and 50 years had the highest percentage at 38.3% followed by those between 51 and 70 years and the least age group between 20 and 35 years, 36.7% and 15%, respectively. Of all the patients 61.7% were found to be SPRA, while the remaining 38.3% were seronegative (SNRA). Altogether 55% of the patients had moderate disease activity, followed by 16.7% who had a remission, 15% had high disease activity and the remaining 13.3% had low disease activity. The metacarpophalangeal (MCP) joint was found to be the only joint that was significantly associated with DAS28 and its involvement was greater among seropositive patients. The most affected joints were found to be shoulders, knees, wrist, MCP, PIP and elbow, in that order.
Conclusion: Females, middle-age group and shoulder joint were the most affected. Most RA was found to be SPRA, and the seropositive group was found to be more associated with high disease activity, while the seronegative group was associated with remission and low disease activity.
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