透视胎儿生长受限诱发高血压的机制

IF 1.5 Q3 PERIPHERAL VASCULAR DISEASE
Integrated Blood Pressure Control Pub Date : 2021-10-09 eCollection Date: 2021-01-01 DOI:10.2147/IBPC.S312868
Benjamin Bhunu, Isabel Riccio, Suttira Intapad
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引用次数: 0

摘要

近几十年来,临床研究和动物实验都表明,胎儿生长受限(FGR)是由不良子宫环境引起的,是高血压和多种成人疾病的危险因素。这一观察结果形成了现在广为接受的健康和疾病的发育起源理论(DOHaD),并为其提供了依据。有大量证据支持胎儿畸形与成人高血压风险增加有关;然而,造成这种相关性的潜在机制仍不清楚。本综述旨在解释高血压胎儿编程领域的最新进展,并简要叙述可能将 FGR 与成人高血压风险增加联系起来的内在机制。我们解释了DOHaD理论,然后提供了临床和基础科学研究中支持胎儿编程成人高血压理论的证据。此外,我们还探讨了可能将 FGR 与成人高血压风险增加联系起来的潜在机制。这些机制包括表观遗传学变化、代谢紊乱、血管功能障碍、神经荷尔蒙损伤以及肾脏生理和功能的改变。我们进一步描述了高血压发育起源中的性别差异,并深入探讨了这一领域的机遇和挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Insights into the Mechanisms of Fetal Growth Restriction-Induced Programming of Hypertension.

Insights into the Mechanisms of Fetal Growth Restriction-Induced Programming of Hypertension.

In recent decades, both clinical and animal studies have shown that fetal growth restriction (FGR), caused by exposure to adverse uterine environments, is a risk factor for hypertension as well as for a variety of adult diseases. This observation has shaped and informed the now widely accepted theory of developmental origins of health and disease (DOHaD). There is a plethora of evidence supporting the association of FGR with increased risk of adult hypertension; however, the underlying mechanisms responsible for this correlation remain unclear. This review aims to explain the current advances in the field of fetal programming of hypertension and a brief narration of the underlying mechanisms that may link FGR to increased risk of adult hypertension. We explain the theory of DOHaD and then provide evidence from both clinical and basic science research which support the theory of fetal programming of adult hypertension. In addition, we have explored the underlying mechanisms that may link FGR to an increased risk of adult hypertension. These mechanisms include epigenetic changes, metabolic disorders, vascular dysfunction, neurohormonal impairment, and alterations in renal physiology and function. We further describe sex differences seen in the developmental origins of hypertension and provide insights into the opportunities and challenges present in this field.

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来源期刊
Integrated Blood Pressure Control
Integrated Blood Pressure Control PERIPHERAL VASCULAR DISEASE-
CiteScore
4.60
自引率
0.00%
发文量
13
审稿时长
16 weeks
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