内源性大麻素系统在重度抑郁症中的作用和功能。

Q1 Medicine

Medical Cannabis and Cannabinoids Pub Date : 2020-12-11 eCollection Date: 2021-06-01 DOI:10.1159/000511979

Erhan Yarar

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引用次数: 7

摘要

内源性大麻素系统(ECS)是一种神经调节系统，在中枢神经系统以及内源性和外源性化合物和炎症反应中起着至关重要的作用。大麻二酚(CBD)是ECS的基本组成部分，是重度抑郁症(MDD)的主要病因和/或保护因素。CBD与脑源性神经营养因子(BDNF)相互作用，BDNF对炎症、下丘脑-垂体-肾上腺(HPA)轴的失调以及MDD患者的许多失衡做出反应，其中ECS是分析、诊断和反映治疗的重要组成部分。ECS和MDD似乎有很强的联系和相互作用，因此在MDD患者中使用ECS和CBD的兴趣正在发展为一种救援手段。

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Role and Function of Endocannabinoid System in Major Depressive Disease.

The endocannabinoid system (ECS) is a neuromodulator system with a crucial role in CNS and the reaction to endogenous and exogenous compounds and inflammation. Cannabidiol (CBD) is a basic part of the ECS which is the overwhelming causative and/or protective factor of major depressive disease (MDD). CBD interacts with brain-derived neurotropic factor (BDNF) that responds to inflammation, dysregulations of the hypothalamic-pituitary-adrenal (HPA) axis, and many more imbalances in MDD patients for which the ECS is a vital part to analyze, diagnose, and reflect the treatment. The ECS and MDD appear to have strong connections and interactions, so interest in ECS and CBD use in MDD patients is developing as a rescue resort.

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来源期刊

Medical Cannabis and Cannabinoids Medicine-Complementary and Alternative Medicine

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

18 weeks