致癌驱动突变的协同作用指导肠上皮细胞的全局翻译。

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2021-05-19 eCollection Date: 2021-01-01 DOI:10.1080/23723556.2021.1879614

Wouter Smit, Jarom Heijmans

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引用次数: 0

摘要

结直肠癌细胞的致瘤转化是由一系列突变驱动的，这些突变导致生长因子受体通路的异常信号传导。利用类器官，我们证明了APC、KRAS、SMAD4和TP53中最常见的驱动突变是全局mRNA翻译能力的增强子，这以mtor依赖的方式与肠细胞生长有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The concerted action of oncogenic driver mutations directs global translation in intestinal epithelial cells.

Oncogenic transformation of colorectal cancer cells is driven by a set of mutations that cause aberrant signaling of growth factor-receptor pathways. Using organoids, we demonstrate that the most frequent driver mutations in APC, KRAS, SMAD4, and TP53 are enhancers of the global mRNA translational capacity, which is linked to intestinal cell growth in an mTOR-dependent manner.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.