白细胞介素-33 (IL-33)及其受体血清刺激2 (ST2)预测同种异体造血细胞移植后的免疫代谢并发症

Clinical Hematology International Pub Date : 2020-05-21 eCollection Date: 2020-09-01 DOI:10.2991/chi.d.200506.002
Uttam K Rao, Brian G Engelhardt
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引用次数: 2

摘要

接受同种异体造血细胞移植(HCT)的患者有许多急性和长期并发症的风险。移植后糖尿病(PTDM)是一种常见但未被认识到的问题。与移植物抗宿主病(GVHD)类似,新发糖尿病的特征是免疫失调,这可能对移植结果产生负面影响。本文将讨论IL-33/ST2在急性GVHD和PTDM发展中的生物学作用,以及该细胞因子轴如何用于预测和治疗移植后的免疫代谢并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predicting Immuno-Metabolic Complications After Allogeneic Hematopoietic Cell Transplant with the Cytokine Interleukin-33 (IL-33) and its Receptor Serum-Stimulation 2 (ST2).

Patients undergoing allogeneic hematopoietic cell transplantation (HCT) are at risk for numerous acute and long-term complications from this procedure. Post-transplant diabetes mellitus (PTDM) is a common but under-recognized problem. Similar to graft-versus-host disease (GVHD), new-onset diabetes is characterized by immune dysregulation that can negatively impact transplant outcomes. This review will discuss the biology of IL-33/ST2 in acute GVHD and PTDM development, and how this cytokine axis could be leveraged for predicting and treating immuno-metabolic complications after transplant.

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