中性粒细胞与淋巴细胞比率作为非转移性肾细胞癌的预后标志物-它是否增加了我们已经知道的?

Q3 Medicine
S Rawoot, C Punatar, V Singh, A Anand, B Shah, S Nagaonkar, V Joshi
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引用次数: 0

摘要

目的:探讨非转移性肾细胞癌(non-metastatic renal cell carcinoma, non-mRCC)术前中性粒细胞/淋巴细胞比值(NLR)与病理分期、Fuhrman分级、肉瘤样分化、肿瘤坏死及淋巴结阳性的相关性及其对预后的影响。材料和方法:这项回顾性、前瞻性、观察性研究是在印度孟买的一家三级保健中心完成的。2015年7月至2018年4月期间所有非mrcc患者均纳入研究。同时存在全身性感染、既往免疫治疗和长期使用类固醇的患者被排除在外。NLR离手术最近,但在手术前一个月内使用。结果:纳入113例患者,年龄18-81岁(男性83例,女性30例)。75%为透明细胞RCC。62%的人患有1期疾病。58%的患者为Fuhrman 2级。淋巴结转移10例,肉瘤样分化6例,肿瘤坏死40例。结论:NLR与较高的T分期及肿瘤坏死有显著相关性。NLR可与已建立的预后标志物相结合,以提高预后评分的准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neutrophil to lymphocyte ratio as a prognostic marker for non-metastatic renal cell carcinoma - does it add to what we already know?

Aim: To study the correlation of pre-operative neutrophil to lymphocyte ratio (NLR) with pathological stage, Fuhrman grade, sarcomatoid differentiation, tumor necrosis and lymph node positivity and its prognostic role in non-metastatic renal cell carcinoma (non-mRCC).

Materials and methods: This retro-prospective, observational study was done at a tertiary care center in Mumbai, India. All patients with non-mRCC from July 2015 to April 2018 were included. Patients with co-existing systemic infection, prior immunotherapy, and long-term steroids were excluded. NLR closest to surgery, but within one month prior to surgery was used. Patients were stratified as NLR ≥ 3.0 or < 3. NLR was correlated with known prognostic factors by Pearson's correlation.

Results: 113 patients, aged 18-81 years (83 males and 30 females) were included. 75% had clear cell RCC. 62% had stage 1 disease. 58% patients had Fuhrman Grade 2. 10 patients had lymph node metastasis, 6 had sarcomatoid differentiation, 40 had tumor necrosis. The NLR was < 3 in 72 patients. Statistically significant correlation between NLR and tumor stage (p = 0.0054) as well as NLR and tumor necrosis (p = 0.0128) was shown.

Conclusions: NLR correlates significantly with higher T stage and tumor necrosis. NLR may be integrated with well-established prognostic markers to improve the accuracy of prognostic scores.

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来源期刊
Experimental oncology
Experimental oncology Medicine-Oncology
CiteScore
1.40
自引率
0.00%
发文量
49
期刊介绍: The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.
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