南印度急性中耳炎儿童耳病原体的鼻咽定植-病例对照初步研究

IF 1.4 Q2 OTORHINOLARYNGOLOGY
M. Napolean , V. Rosemol , M. John , A.M. Varghese , J. Periyasamy , V. Balaji , P. Naina
{"title":"南印度急性中耳炎儿童耳病原体的鼻咽定植-病例对照初步研究","authors":"M. Napolean ,&nbsp;V. Rosemol ,&nbsp;M. John ,&nbsp;A.M. Varghese ,&nbsp;J. Periyasamy ,&nbsp;V. Balaji ,&nbsp;P. Naina","doi":"10.1016/j.joto.2021.02.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Acute otitis media (AOM) is an inflammatory disease of the middle ear causing significant morbidity in early childhood. A pilot study was undertaken to identify the role of various risk factors South Indian children with AOM, especially the role of nasopharyngeal otopathogens.</p></div><div><h3>Methodology</h3><p>A prospective case control pilot study was conducted in children aged below six years, presenting to a single tertiary care from 2018 to 2019. Fifty cases with AOM and 45 age and gender matched controls were recruited. Two nasopharyngeal swabs were collected, one was processed for bacterial culture. The other swab was processed according to the CDC recommended broth enrichment method to identify carriage of <em>S. pneumoniae.</em> Subsequent serotyping was done by Quellung method and conventional sequential multiplex PCR.</p></div><div><h3>Result</h3><p>Otalgia was the major presentation seen in 92% of the children with AOM. None of the clinical and demographic characteristics were found to be statistically significant between the cases and controls. The most common otopathogen was <em>S. pneumoniae</em> (55%) followed by <em>H. influenza</em> (29%). The common <em>S. pneumoniae</em> serotypes encountered were 11A and 19F.Nasopharyngeal colonization with <em>S. pneumoniae</em> [OR 6.57, p &lt; 0.003] and <em>H. influenzae</em> [OR14.18, p &lt; 0.003] were significant risk factors for AOM in children. The risk increased with co-colonization (OR 13.89,p &lt; 0.003).</p></div><div><h3>Conclusion</h3><p>This study strengthens the significant association between nasopharyngeal colonization of otopathogens and AOM as a risk factor that is enhanced by co-colonization.<em>S. pneumoniae</em> was the main otopathogen in this population, serotypes 11A and 19F being the most common.</p></div>","PeriodicalId":37466,"journal":{"name":"Journal of Otology","volume":"16 4","pages":"Pages 220-224"},"PeriodicalIF":1.4000,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.joto.2021.02.004","citationCount":"2","resultStr":"{\"title\":\"Nasopharyngeal colonization of otopathogens in South Indian children with acute otitis media – A case control pilot study\",\"authors\":\"M. Napolean ,&nbsp;V. Rosemol ,&nbsp;M. John ,&nbsp;A.M. Varghese ,&nbsp;J. Periyasamy ,&nbsp;V. Balaji ,&nbsp;P. Naina\",\"doi\":\"10.1016/j.joto.2021.02.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Acute otitis media (AOM) is an inflammatory disease of the middle ear causing significant morbidity in early childhood. A pilot study was undertaken to identify the role of various risk factors South Indian children with AOM, especially the role of nasopharyngeal otopathogens.</p></div><div><h3>Methodology</h3><p>A prospective case control pilot study was conducted in children aged below six years, presenting to a single tertiary care from 2018 to 2019. Fifty cases with AOM and 45 age and gender matched controls were recruited. Two nasopharyngeal swabs were collected, one was processed for bacterial culture. The other swab was processed according to the CDC recommended broth enrichment method to identify carriage of <em>S. pneumoniae.</em> Subsequent serotyping was done by Quellung method and conventional sequential multiplex PCR.</p></div><div><h3>Result</h3><p>Otalgia was the major presentation seen in 92% of the children with AOM. None of the clinical and demographic characteristics were found to be statistically significant between the cases and controls. The most common otopathogen was <em>S. pneumoniae</em> (55%) followed by <em>H. influenza</em> (29%). The common <em>S. pneumoniae</em> serotypes encountered were 11A and 19F.Nasopharyngeal colonization with <em>S. pneumoniae</em> [OR 6.57, p &lt; 0.003] and <em>H. influenzae</em> [OR14.18, p &lt; 0.003] were significant risk factors for AOM in children. The risk increased with co-colonization (OR 13.89,p &lt; 0.003).</p></div><div><h3>Conclusion</h3><p>This study strengthens the significant association between nasopharyngeal colonization of otopathogens and AOM as a risk factor that is enhanced by co-colonization.<em>S. pneumoniae</em> was the main otopathogen in this population, serotypes 11A and 19F being the most common.</p></div>\",\"PeriodicalId\":37466,\"journal\":{\"name\":\"Journal of Otology\",\"volume\":\"16 4\",\"pages\":\"Pages 220-224\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2021-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.joto.2021.02.004\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Otology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1672293021000209\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Otology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1672293021000209","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 2

摘要

背景:急性中耳炎(AOM)是一种中耳炎症性疾病,在儿童早期发病率很高。开展了一项试点研究,以确定南印度急性中耳炎儿童的各种风险因素的作用,特别是鼻咽耳病原体的作用。方法前瞻性病例对照试点研究在2018年至2019年在单一三级医疗机构就诊的6岁以下儿童中进行。招募了50例AOM患者和45例年龄和性别匹配的对照组。收集2份鼻咽拭子,1份进行细菌培养。另一拭子按照CDC推荐的肉汤富集法进行处理,以鉴定携带肺炎链球菌。随后采用Quellung法和常规序列多重PCR进行血清分型。结果92%的AOM患儿以痛感为主要表现。没有发现病例和对照组之间的临床和人口学特征有统计学意义。最常见的耳病原体是肺炎链球菌(55%),其次是流感嗜血杆菌(29%)。常见的肺炎链球菌血清型为11A型和19F型。肺炎链球菌鼻咽部定植[OR 6.57, p <0.003]和流感嗜血杆菌[OR14.18, p <0.003]是儿童AOM的重要危险因素。共定殖的风险增加(OR 13.89,p <0.003)。结论耳部病原菌定植与AOM之间存在显著的相关性,而共定植增强了这一相关性。肺炎是该人群的主要耳病原体,血清型11A和19F最为常见。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nasopharyngeal colonization of otopathogens in South Indian children with acute otitis media – A case control pilot study

Nasopharyngeal colonization of otopathogens in South Indian children with acute otitis media – A case control pilot study

Background

Acute otitis media (AOM) is an inflammatory disease of the middle ear causing significant morbidity in early childhood. A pilot study was undertaken to identify the role of various risk factors South Indian children with AOM, especially the role of nasopharyngeal otopathogens.

Methodology

A prospective case control pilot study was conducted in children aged below six years, presenting to a single tertiary care from 2018 to 2019. Fifty cases with AOM and 45 age and gender matched controls were recruited. Two nasopharyngeal swabs were collected, one was processed for bacterial culture. The other swab was processed according to the CDC recommended broth enrichment method to identify carriage of S. pneumoniae. Subsequent serotyping was done by Quellung method and conventional sequential multiplex PCR.

Result

Otalgia was the major presentation seen in 92% of the children with AOM. None of the clinical and demographic characteristics were found to be statistically significant between the cases and controls. The most common otopathogen was S. pneumoniae (55%) followed by H. influenza (29%). The common S. pneumoniae serotypes encountered were 11A and 19F.Nasopharyngeal colonization with S. pneumoniae [OR 6.57, p < 0.003] and H. influenzae [OR14.18, p < 0.003] were significant risk factors for AOM in children. The risk increased with co-colonization (OR 13.89,p < 0.003).

Conclusion

This study strengthens the significant association between nasopharyngeal colonization of otopathogens and AOM as a risk factor that is enhanced by co-colonization.S. pneumoniae was the main otopathogen in this population, serotypes 11A and 19F being the most common.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Otology
Journal of Otology Medicine-Otorhinolaryngology
CiteScore
2.70
自引率
0.00%
发文量
461
审稿时长
18 days
期刊介绍: Journal of Otology is an open access, peer-reviewed journal that publishes research findings from disciplines related to both clinical and basic science aspects of auditory and vestibular system and diseases of the ear. This journal welcomes submissions describing original experimental research that may improve our understanding of the mechanisms underlying problems of basic or clinical significance and treatment of patients with disorders of the auditory and vestibular systems. In addition to original papers the journal also offers invited review articles on current topics written by leading experts in the field. The journal is of primary importance for all scientists and practitioners interested in audiology, otology and neurotology, auditory neurosciences and related disciplines. Journal of Otology welcomes contributions from scholars in all countries and regions across the world.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信