Tais Monteiro Magne, Thamires de Oliveira Vieira, Luciana Magalhães Rebelo Alencar, Francisco Franciné Maia Junior, Sara Gemini-Piperni, Samuel V Carneiro, Lillian M U D Fechine, Rafael M Freire, Kirill Golokhvast, Pierangelo Metrangolo, Pierre B A Fechine, Ralph Santos-Oliveira
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Hence, further studies to explain the interactions of these nanomaterials with biological systems are fundamental. This review has shown the applicability of the graphene family in several biomedical modalities, with particular attention for cancer therapy and diagnosis, as a potent theranostic. This ability is derivative from the considerable number of forms that the graphene family can assume. The graphene-based materials biodistribution profile, clearance, toxicity, and cytotoxicity, interacting with biological systems, are discussed here, focusing on its synthesis methodology, physicochemical properties, and production quality. 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Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications.
Over the past few years, there has been a growing potential use of graphene and its derivatives in several biomedical areas, such as drug delivery systems, biosensors, and imaging systems, especially for having excellent optical, electronic, thermal, and mechanical properties. Therefore, nanomaterials in the graphene family have shown promising results in several areas of science. The different physicochemical properties of graphene and its derivatives guide its biocompatibility and toxicity. Hence, further studies to explain the interactions of these nanomaterials with biological systems are fundamental. This review has shown the applicability of the graphene family in several biomedical modalities, with particular attention for cancer therapy and diagnosis, as a potent theranostic. This ability is derivative from the considerable number of forms that the graphene family can assume. The graphene-based materials biodistribution profile, clearance, toxicity, and cytotoxicity, interacting with biological systems, are discussed here, focusing on its synthesis methodology, physicochemical properties, and production quality. Despite the growing increase in the bioavailability and toxicity studies of graphene and its derivatives, there is still much to be unveiled to develop safe and effective formulations.
期刊介绍:
The Journal of Nanostructure in Chemistry (JNC) publishes cutting-edge research at the intersections of chemistry, biology, biotechnology, materials science, physics, and engineering. It features high-quality research, perspectives, and review articles covering various disciplines within the natural sciences, biomedicine, and engineering. The journal's scope includes, but is not limited to, the following topics:
Target drug and gene delivery
Tissue engineering and regenerative medicine
Cancer therapy
Diagnosis and Bioimaging
Electrochemical detection and sensing
Food industry and packaging
Environments (catalyst, coatings, and water treatment)
Energy (fuel cells, capacitor, laser)