研究血清抗体、T淋巴细胞和呼吸道合胞病毒病之间关系的动物研究的系统综述和meta分析。

Joseph McGinley, Ryan Thwaites, Will Brebner, Lewis Greenan-Barrett, Jeroen Aerssens, Deniz Öner, Louis Bont, Joanne Wildenbeest, Federico Martinón-Torres, Harish Nair, Andrew J Pollard, Peter Openshaw, Simon Drysdale
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引用次数: 0

摘要

背景:呼吸道合胞病毒(RSV)感染发生在全球人群中,引起不同严重程度的疾病,对婴儿和老年人(65岁以下)的影响不成比例。免疫反应可以起到保护作用,但也会导致疾病。动物实验研究可以对免疫反应进行详细调查,为临床问题提供见解,并加速被动和主动疫苗接种的发展。我们的目的是回顾抗体和t细胞反应在动物RSV疾病严重程度中的作用。方法:对动物研究进行系统回顾和荟萃分析,研究t细胞反应/表型或抗体滴度与RSV疾病严重程度之间的关系。从1980年1月至2018年5月,对PubMed、Zoological Record和Embase数据库进行了筛选,以确定RSV感染的动物研究,这些研究以疾病严重程度为结果评估血清抗体滴度或T淋巴细胞。最后的综述纳入了63项研究。结果:RSV特异性抗体在小鼠中显示出对疾病的保护作用,但这种作用在牛RSV中不太明显。强烈的t细胞、Th1、Th2、Th17、CD4/CD8反应和弱的Treg反应伴随着小鼠的严重疾病。结论:小鼠研究表明,T淋巴细胞活性(特别是CD4和CD8 T细胞)的测量可能是严重程度的预测性生物标志物。值得进一步研究以验证这些结果并评估作为人类疾病生物标志物的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Systematic Review and Meta-analysis of Animal Studies Investigating the Relationship Between Serum Antibody, T Lymphocytes, and Respiratory Syncytial Virus Disease.

Background: Respiratory syncytial virus (RSV) infections occur in human populations around the globe, causing disease of variable severity, disproportionately affecting infants and older adults (>65 years of age). Immune responses can be protective but also contribute to disease. Experimental studies in animals enable detailed investigation of immune responses, provide insights into clinical questions, and accelerate the development of passive and active vaccination. We aimed to review the role of antibody and T-cell responses in relation to RSV disease severity in animals.

Methods: Systematic review and meta-analysis of animal studies examining the association between T-cell responses/phenotype or antibody titers and severity of RSV disease. The PubMed, Zoological Record, and Embase databases were screened from January 1980 to May 2018 to identify animal studies of RSV infection that assessed serum antibody titer or T lymphocytes with disease severity as an outcome. Sixty-three studies were included in the final review.

Results: RSV-specific antibody appears to protect from disease in mice, but such an effect was less evident in bovine RSV. Strong T-cell, Th1, Th2, Th17, CD4/CD8 responses, and weak Treg responses accompany severe disease in mice.

Conclusions: Murine studies suggest that measures of T-lymphocyte activity (particularly CD4 and CD8 T cells) may be predictive biomarkers of severity. Further inquiry is merited to validate these results and assess relevance as biomarkers for human disease.

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