识别自身免疫和自身抗体在癫痫中的作用:综述。

IF 21.3 1区 医学 Q1 CLINICAL NEUROLOGY
Claude Steriade, Lisa Gillinder, Kirsty Rickett, Gunter Hartel, Lindsay Higdon, Jeffrey Britton, Jacqueline French
{"title":"识别自身免疫和自身抗体在癫痫中的作用:综述。","authors":"Claude Steriade,&nbsp;Lisa Gillinder,&nbsp;Kirsty Rickett,&nbsp;Gunter Hartel,&nbsp;Lindsay Higdon,&nbsp;Jeffrey Britton,&nbsp;Jacqueline French","doi":"10.1001/jamaneurol.2021.3113","DOIUrl":null,"url":null,"abstract":"<p><strong>Importance: </strong>The literature on neural autoantibody positivity in epilepsy has expanded over the last decade, with an increased interest among clinicians in identifying potentially treatable causes of otherwise refractory seizures.</p><p><strong>Observations: </strong>Prior studies have reported a wide range of neural autoantibody positivity rates among various epilepsy populations, with the highest frequency reported in individuals with focal epilepsy of unknown cause and new-onset seizures. The antibodies in some cases are of uncertain significance, and their presence can cause conundrums regarding therapy.</p><p><strong>Conclusions and relevance: </strong>There is likely some role for neural autoantibody assessment in patients with unexplained epilepsy who lack clear evidence of autoimmune encephalitis, but the clinical implications of such testing remain unclear owing to limitations in previous published studies. A framework for study design to bridge the current gaps in knowledge on autoimmune-associated epilepsy is proposed.</p>","PeriodicalId":14677,"journal":{"name":"JAMA neurology","volume":" ","pages":"1383-1390"},"PeriodicalIF":21.3000,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"10","resultStr":"{\"title\":\"Discerning the Role of Autoimmunity and Autoantibodies in Epilepsy: A Review.\",\"authors\":\"Claude Steriade,&nbsp;Lisa Gillinder,&nbsp;Kirsty Rickett,&nbsp;Gunter Hartel,&nbsp;Lindsay Higdon,&nbsp;Jeffrey Britton,&nbsp;Jacqueline French\",\"doi\":\"10.1001/jamaneurol.2021.3113\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Importance: </strong>The literature on neural autoantibody positivity in epilepsy has expanded over the last decade, with an increased interest among clinicians in identifying potentially treatable causes of otherwise refractory seizures.</p><p><strong>Observations: </strong>Prior studies have reported a wide range of neural autoantibody positivity rates among various epilepsy populations, with the highest frequency reported in individuals with focal epilepsy of unknown cause and new-onset seizures. The antibodies in some cases are of uncertain significance, and their presence can cause conundrums regarding therapy.</p><p><strong>Conclusions and relevance: </strong>There is likely some role for neural autoantibody assessment in patients with unexplained epilepsy who lack clear evidence of autoimmune encephalitis, but the clinical implications of such testing remain unclear owing to limitations in previous published studies. A framework for study design to bridge the current gaps in knowledge on autoimmune-associated epilepsy is proposed.</p>\",\"PeriodicalId\":14677,\"journal\":{\"name\":\"JAMA neurology\",\"volume\":\" \",\"pages\":\"1383-1390\"},\"PeriodicalIF\":21.3000,\"publicationDate\":\"2021-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JAMA neurology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1001/jamaneurol.2021.3113\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JAMA neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1001/jamaneurol.2021.3113","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 10

摘要

重要性:在过去十年中,关于癫痫患者神经自身抗体阳性的文献越来越多,临床医生对确定难治性癫痫发作的潜在可治疗原因越来越感兴趣。观察:先前的研究报道了各种癫痫人群中神经自身抗体阳性率的广泛范围,其中未知原因的局灶性癫痫和新发癫痫的个体报告的频率最高。这些抗体在某些情况下具有不确定的意义,它们的存在可能导致治疗方面的难题。结论和相关性:神经自身抗体评估在缺乏明确自身免疫性脑炎证据的不明原因癫痫患者中可能有一定作用,但由于先前发表的研究的局限性,这种测试的临床意义尚不清楚。提出了一个研究设计框架,以弥合目前在自身免疫相关癫痫知识方面的差距。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Discerning the Role of Autoimmunity and Autoantibodies in Epilepsy: A Review.

Importance: The literature on neural autoantibody positivity in epilepsy has expanded over the last decade, with an increased interest among clinicians in identifying potentially treatable causes of otherwise refractory seizures.

Observations: Prior studies have reported a wide range of neural autoantibody positivity rates among various epilepsy populations, with the highest frequency reported in individuals with focal epilepsy of unknown cause and new-onset seizures. The antibodies in some cases are of uncertain significance, and their presence can cause conundrums regarding therapy.

Conclusions and relevance: There is likely some role for neural autoantibody assessment in patients with unexplained epilepsy who lack clear evidence of autoimmune encephalitis, but the clinical implications of such testing remain unclear owing to limitations in previous published studies. A framework for study design to bridge the current gaps in knowledge on autoimmune-associated epilepsy is proposed.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
JAMA neurology
JAMA neurology CLINICAL NEUROLOGY-
CiteScore
41.90
自引率
1.70%
发文量
250
期刊介绍: JAMA Neurology is an international peer-reviewed journal for physicians caring for people with neurologic disorders and those interested in the structure and function of the normal and diseased nervous system. The Archives of Neurology & Psychiatry began publication in 1919 and, in 1959, became 2 separate journals: Archives of Neurology and Archives of General Psychiatry. In 2013, their names changed to JAMA Neurology and JAMA Psychiatry, respectively. JAMA Neurology is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信