{"title":"“人支原体与其他生殖器病原体没有共同的危险因素”:来自南非孕妇队列的研究结果。","authors":"Meleshni Naicker, Fazana Dessai, Ravesh Singh, Nireshni Mitchev, Partson Tinarwo, Nathlee S Abbai","doi":"10.4102/sajid.v36i1.207","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The role of <i>Mycoplasma hominis</i> (<i>M. hominis</i>) as a genital tract pathogen was still debatable. This study identified the risk factors associated with the prevalence of <i>M. hominis</i> in South African pregnant women.</p><p><strong>Methods: </strong>This was a cross-sectional analysis of <i>n</i> = 221 prenatal patients attending a Durban hospital during November 2017 to April 2018. <i>M. hominis</i> was detected from urine samples using the quantitative polymerase chain reaction. The population characteristics were described using frequencies stratified by the infection status of <i>M. hominis.</i> In addition, a univariate analysis was used to assess the relationship between each risk factor and infection status. The analysis further considered logistic regression to assess the influence of these risk factors univariately and in the presence of other factors. The coinfection rate between <i>M. hominis</i> and bacterial vaginosis (BV), <i>Trichomonas vaginalis</i> (<i>T. vaginalis</i>), <i>Mycoplasma genitalium (M. genitalium)</i> and <i>Candida</i> species was also determined. All the tests were conducted at 5% level of significance.</p><p><strong>Results: </strong>The prevalence of <i>M. hominis</i> in this study population was 48% (106/221). In the univariate analysis, factors significantly associated with <i>M. hominis</i> positivity included having past abnormal vaginal discharge (<i>p</i> = 0.037), having current abnormal vaginal discharge (<i>p</i> = 0.010) and a borderline significance (<i>p</i> = 0.052), which were noted for previous pre-term delivery. However, none of these factors were sustained in the multivariate analysis. There was a statistically significant association between <i>M. hominis</i> and BV positivity (<i>p</i> < 0.001). Similarly, <i>M. hominis</i> and <i>M. genitalium</i> positivity was significant (<i>p</i> = 0.006).</p><p><strong>Conclusion: </strong>This study showed that <i>M. hominis</i> does not share common risk factors with known genital tract pathogens in a population of pregnant women and therefore cannot be considered a genital tract pathogen.</p>","PeriodicalId":44007,"journal":{"name":"Southern African Journal of Infectious Diseases","volume":"36 1","pages":"207"},"PeriodicalIF":1.4000,"publicationDate":"2021-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377787/pdf/","citationCount":"1","resultStr":"{\"title\":\"'<i>Mycoplasma hominis</i> does not share common risk factors with other genital pathogens': Findings from a South African pregnant cohort.\",\"authors\":\"Meleshni Naicker, Fazana Dessai, Ravesh Singh, Nireshni Mitchev, Partson Tinarwo, Nathlee S Abbai\",\"doi\":\"10.4102/sajid.v36i1.207\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The role of <i>Mycoplasma hominis</i> (<i>M. hominis</i>) as a genital tract pathogen was still debatable. This study identified the risk factors associated with the prevalence of <i>M. hominis</i> in South African pregnant women.</p><p><strong>Methods: </strong>This was a cross-sectional analysis of <i>n</i> = 221 prenatal patients attending a Durban hospital during November 2017 to April 2018. <i>M. hominis</i> was detected from urine samples using the quantitative polymerase chain reaction. The population characteristics were described using frequencies stratified by the infection status of <i>M. hominis.</i> In addition, a univariate analysis was used to assess the relationship between each risk factor and infection status. The analysis further considered logistic regression to assess the influence of these risk factors univariately and in the presence of other factors. The coinfection rate between <i>M. hominis</i> and bacterial vaginosis (BV), <i>Trichomonas vaginalis</i> (<i>T. vaginalis</i>), <i>Mycoplasma genitalium (M. genitalium)</i> and <i>Candida</i> species was also determined. All the tests were conducted at 5% level of significance.</p><p><strong>Results: </strong>The prevalence of <i>M. hominis</i> in this study population was 48% (106/221). In the univariate analysis, factors significantly associated with <i>M. hominis</i> positivity included having past abnormal vaginal discharge (<i>p</i> = 0.037), having current abnormal vaginal discharge (<i>p</i> = 0.010) and a borderline significance (<i>p</i> = 0.052), which were noted for previous pre-term delivery. However, none of these factors were sustained in the multivariate analysis. There was a statistically significant association between <i>M. hominis</i> and BV positivity (<i>p</i> < 0.001). Similarly, <i>M. hominis</i> and <i>M. genitalium</i> positivity was significant (<i>p</i> = 0.006).</p><p><strong>Conclusion: </strong>This study showed that <i>M. hominis</i> does not share common risk factors with known genital tract pathogens in a population of pregnant women and therefore cannot be considered a genital tract pathogen.</p>\",\"PeriodicalId\":44007,\"journal\":{\"name\":\"Southern African Journal of Infectious Diseases\",\"volume\":\"36 1\",\"pages\":\"207\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2021-05-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8377787/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Southern African Journal of Infectious Diseases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4102/sajid.v36i1.207\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Southern African Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4102/sajid.v36i1.207","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
'Mycoplasma hominis does not share common risk factors with other genital pathogens': Findings from a South African pregnant cohort.
Background: The role of Mycoplasma hominis (M. hominis) as a genital tract pathogen was still debatable. This study identified the risk factors associated with the prevalence of M. hominis in South African pregnant women.
Methods: This was a cross-sectional analysis of n = 221 prenatal patients attending a Durban hospital during November 2017 to April 2018. M. hominis was detected from urine samples using the quantitative polymerase chain reaction. The population characteristics were described using frequencies stratified by the infection status of M. hominis. In addition, a univariate analysis was used to assess the relationship between each risk factor and infection status. The analysis further considered logistic regression to assess the influence of these risk factors univariately and in the presence of other factors. The coinfection rate between M. hominis and bacterial vaginosis (BV), Trichomonas vaginalis (T. vaginalis), Mycoplasma genitalium (M. genitalium) and Candida species was also determined. All the tests were conducted at 5% level of significance.
Results: The prevalence of M. hominis in this study population was 48% (106/221). In the univariate analysis, factors significantly associated with M. hominis positivity included having past abnormal vaginal discharge (p = 0.037), having current abnormal vaginal discharge (p = 0.010) and a borderline significance (p = 0.052), which were noted for previous pre-term delivery. However, none of these factors were sustained in the multivariate analysis. There was a statistically significant association between M. hominis and BV positivity (p < 0.001). Similarly, M. hominis and M. genitalium positivity was significant (p = 0.006).
Conclusion: This study showed that M. hominis does not share common risk factors with known genital tract pathogens in a population of pregnant women and therefore cannot be considered a genital tract pathogen.
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