{"title":"溶质载体家族2成员的综合分析显示，SLC2A4是乳腺癌独立的有利预后生物标志物。","authors":"Zhenyu Shi, Jiahao Liu, Fei Wang, Yongqiang Li","doi":"10.1080/19336950.2021.1973788","DOIUrl":null,"url":null,"abstract":"<p><p>Most of <i>Solute carrier family-2</i> (SLC2) members play a key role of facilitative transporters, and glucose transporter (GLUT) proteins encoded by <i>SLC2s</i> can transport hexoses or polyols. However, the function and mechanism of <i>SLC2s</i> remain unclear in human cancers. Here, we explored the dysregulated expression, prognostic values, epigenetic, genetic alterations, and biomolecular network of <i>SLC2s</i> in human cancers. According to the data from public-omicsrepository, <i>SLC2A4</i> (<i>GLUT4</i>) was found to be significantly downregulated in most cancers, and higher messenger RNA (mRNA) expression of <i>SLC2A4</i> significantly associated with better prognosis of breast cancer (BRCA) patients. Moreover, DNA hypermethylation in the promoter of <i>SLC2A4</i> may affect the regulation of its mRNA expression, and <i>SLC2A4</i> was strongly correlated with pathways, including the translocation of <i>SLC2A4</i> to the plasma membrane and PID INSULIN PATHWAY. In conclusion, these results provide insight into <i>SLC2s</i> in human cancers and suggest that <i>SLC2A4</i> could be an unfavorable prognostic biomarker for the survival of BRCA patients.</p>","PeriodicalId":72555,"journal":{"name":"Channels (Austin, Tex.)","volume":" ","pages":"555-568"},"PeriodicalIF":0.0000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425726/pdf/","citationCount":"3","resultStr":"{\"title\":\"Integrated analysis of Solute carrier family-2 members reveals SLC2A4 as an independent favorable prognostic biomarker for breast cancer.\",\"authors\":\"Zhenyu Shi, Jiahao Liu, Fei Wang, Yongqiang Li\",\"doi\":\"10.1080/19336950.2021.1973788\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Most of <i>Solute carrier family-2</i> (SLC2) members play a key role of facilitative transporters, and glucose transporter (GLUT) proteins encoded by <i>SLC2s</i> can transport hexoses or polyols. However, the function and mechanism of <i>SLC2s</i> remain unclear in human cancers. Here, we explored the dysregulated expression, prognostic values, epigenetic, genetic alterations, and biomolecular network of <i>SLC2s</i> in human cancers. According to the data from public-omicsrepository, <i>SLC2A4</i> (<i>GLUT4</i>) was found to be significantly downregulated in most cancers, and higher messenger RNA (mRNA) expression of <i>SLC2A4</i> significantly associated with better prognosis of breast cancer (BRCA) patients. Moreover, DNA hypermethylation in the promoter of <i>SLC2A4</i> may affect the regulation of its mRNA expression, and <i>SLC2A4</i> was strongly correlated with pathways, including the translocation of <i>SLC2A4</i> to the plasma membrane and PID INSULIN PATHWAY. In conclusion, these results provide insight into <i>SLC2s</i> in human cancers and suggest that <i>SLC2A4</i> could be an unfavorable prognostic biomarker for the survival of BRCA patients.</p>\",\"PeriodicalId\":72555,\"journal\":{\"name\":\"Channels (Austin, Tex.)\",\"volume\":\" \",\"pages\":\"555-568\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425726/pdf/\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Channels (Austin, Tex.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/19336950.2021.1973788\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Channels (Austin, Tex.)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/19336950.2021.1973788","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Integrated analysis of Solute carrier family-2 members reveals SLC2A4 as an independent favorable prognostic biomarker for breast cancer.
Most of Solute carrier family-2 (SLC2) members play a key role of facilitative transporters, and glucose transporter (GLUT) proteins encoded by SLC2s can transport hexoses or polyols. However, the function and mechanism of SLC2s remain unclear in human cancers. Here, we explored the dysregulated expression, prognostic values, epigenetic, genetic alterations, and biomolecular network of SLC2s in human cancers. According to the data from public-omicsrepository, SLC2A4 (GLUT4) was found to be significantly downregulated in most cancers, and higher messenger RNA (mRNA) expression of SLC2A4 significantly associated with better prognosis of breast cancer (BRCA) patients. Moreover, DNA hypermethylation in the promoter of SLC2A4 may affect the regulation of its mRNA expression, and SLC2A4 was strongly correlated with pathways, including the translocation of SLC2A4 to the plasma membrane and PID INSULIN PATHWAY. In conclusion, these results provide insight into SLC2s in human cancers and suggest that SLC2A4 could be an unfavorable prognostic biomarker for the survival of BRCA patients.
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