利用生物信息学数据和工具对人类肥胖相关基因进行比较分析。

IF 0.5 4区 医学 Q4 GENETICS & HEREDITY
Balkan Journal of Medical Genetics Pub Date : 2021-07-27 eCollection Date: 2021-06-01 DOI:10.2478/bjmg-2021-0012
Z S Musliji, A K Pollozhani, K Lisichkov, M Deligios, Z T Popovski
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引用次数: 2

摘要

肥胖已经成为一个严重的全球问题,仍然需要解决。导致肥胖的因素之一是遗传易感性。所涉及的基因的身份和特征尚未得到充分证实。分析基因对肥胖的影响是解决这个问题的重要一步。在这项计算机研究中,使用在线生物信息学工具,我们评估了四种被认为导致肥胖的基因的作用。收集并分析了肥胖基因FTO(脂肪量与肥胖相关蛋白)、PPARG(过氧化物酶体增殖物激活受体γ)、ADRB3(肾上腺素能受体β 3)和FABP2(脂肪酸结合蛋白2)的序列数据。在研究的第一部分,收集和整理了有关基因的信息,并从国家生物技术信息中心(NCBI)提取了FASTA格式的数据。第二部分,通过比较智人(Homo sapiens)、小鼠(Mus musculus)和鸡(Gallus)三种生物,对所有基因进行分析。在本研究的第三部分,利用blast局部比对搜索工具(blast)和分子进化遗传学分析软件(MEGA X)构建了4个基因的系统发育树。我们的分析表明,所有这些基因的功能都与超重和肥胖有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Comparative Analysis of Genes Associated with Obesity in Humans Using Bioinformatic Data and Tools.

Comparative Analysis of Genes Associated with Obesity in Humans Using Bioinformatic Data and Tools.

Comparative Analysis of Genes Associated with Obesity in Humans Using Bioinformatic Data and Tools.

Comparative Analysis of Genes Associated with Obesity in Humans Using Bioinformatic Data and Tools.

Obesity has become a serious global problem that still needs a solution. One of the factors that leads to obesity is genetic predisposition. The identity and characteristics of the genes involved have not yet been fully confirmed. Analyzing the genetic contribution to obesity is a major step towards the solution. In this in silico study, using online bioinformatics tools, we evaluate the role of four genes that are believed to contribute to obesity. Data were collected and analyzed for the sequences of four so-called obesity genes: FTO (fat mass and obesity-associated protein), PPARG (peroxisome proliferator activated receptor γ), ADRB3 (adrenergic receptor β 3) and FABP2 (fatty acid binding protein 2). In the first part of the research, information about the genes was collected and organized and data in FASTA, format are extracted from the National Center for Biotechnology Information (NCBI). In the second part, all genes were analyzed by comparing three species of organisms, Homo sapiens (human), Mus musculus (mouse) and Gallus (chicken). In the third part of this study, phylogenetic trees were constructed for each of the four genes, using blast local alignment search tool (BLAST) and molecular evolutionary genetics analysis (MEGA X) software. Our analysis reveals that the functions of all these genes are associated with overweight and obesity.

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来源期刊
CiteScore
1.00
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Balkan Journal of Medical Genetics is a journal in the English language for publication of articles involving all branches of medical genetics: human cytogenetics, molecular genetics, clinical genetics, immunogenetics, oncogenetics, pharmacogenetics, population genetics, genetic screening and diagnosis of monogenic and polygenic diseases, prenatal and preimplantation genetic diagnosis, genetic counselling, advances in treatment and prevention.
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