{"title":"职业性铅暴露手工业工人的硒、氧化应激和炎症标志物","authors":"Gangam Saikiran, Prasenjit Mitra, Shailja Sharma, Pvsn Kiran Kumar, Praveen Sharma","doi":"10.1080/19338244.2021.1968780","DOIUrl":null,"url":null,"abstract":"<p><p>Occupational Lead (Pb) exposure increases reactive oxygen species and has been reported to impact inflammatory response by modulating intracellular signaling pathways. Selenium (Se) a vital component of the antioxidant system that plays an important role in modulating cytokines. The present study evaluated Se, malondialdehyde (MDA), total antioxidant capacity (TAC) and cytokines (IL-6, TNF-α, IL-10, IL-17a) in 81 Pb exposed male workers. The median (range) of blood lead level (BLL) and Se were 5 (0.50-31.76) µg/dL and 104 (46.9-189.6) µg/L respectively. The Se, TAC levels were decreased, and MDA, IL-6 levels were increased in the high Pb group (>5μg/dL). Blood lead level independently predicted oxidative stress and antioxidant status. Selenium, TAC levels negatively and MDA, IL-6 levels positively correlated with BLL. Association of Se with IL-6 and TAC suggests some probable role of Se in the underlined mechanism of Pb toxicity.</p>","PeriodicalId":8173,"journal":{"name":"Archives of Environmental & Occupational Health","volume":" ","pages":"561-567"},"PeriodicalIF":0.9000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Selenium, oxidative stress and inflammatory markers in handicraft workers occupationally exposed to lead.\",\"authors\":\"Gangam Saikiran, Prasenjit Mitra, Shailja Sharma, Pvsn Kiran Kumar, Praveen Sharma\",\"doi\":\"10.1080/19338244.2021.1968780\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Occupational Lead (Pb) exposure increases reactive oxygen species and has been reported to impact inflammatory response by modulating intracellular signaling pathways. Selenium (Se) a vital component of the antioxidant system that plays an important role in modulating cytokines. The present study evaluated Se, malondialdehyde (MDA), total antioxidant capacity (TAC) and cytokines (IL-6, TNF-α, IL-10, IL-17a) in 81 Pb exposed male workers. The median (range) of blood lead level (BLL) and Se were 5 (0.50-31.76) µg/dL and 104 (46.9-189.6) µg/L respectively. The Se, TAC levels were decreased, and MDA, IL-6 levels were increased in the high Pb group (>5μg/dL). Blood lead level independently predicted oxidative stress and antioxidant status. Selenium, TAC levels negatively and MDA, IL-6 levels positively correlated with BLL. Association of Se with IL-6 and TAC suggests some probable role of Se in the underlined mechanism of Pb toxicity.</p>\",\"PeriodicalId\":8173,\"journal\":{\"name\":\"Archives of Environmental & Occupational Health\",\"volume\":\" \",\"pages\":\"561-567\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Environmental & Occupational Health\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1080/19338244.2021.1968780\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/8/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Environmental & Occupational Health","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1080/19338244.2021.1968780","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/8/23 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Selenium, oxidative stress and inflammatory markers in handicraft workers occupationally exposed to lead.
Occupational Lead (Pb) exposure increases reactive oxygen species and has been reported to impact inflammatory response by modulating intracellular signaling pathways. Selenium (Se) a vital component of the antioxidant system that plays an important role in modulating cytokines. The present study evaluated Se, malondialdehyde (MDA), total antioxidant capacity (TAC) and cytokines (IL-6, TNF-α, IL-10, IL-17a) in 81 Pb exposed male workers. The median (range) of blood lead level (BLL) and Se were 5 (0.50-31.76) µg/dL and 104 (46.9-189.6) µg/L respectively. The Se, TAC levels were decreased, and MDA, IL-6 levels were increased in the high Pb group (>5μg/dL). Blood lead level independently predicted oxidative stress and antioxidant status. Selenium, TAC levels negatively and MDA, IL-6 levels positively correlated with BLL. Association of Se with IL-6 and TAC suggests some probable role of Se in the underlined mechanism of Pb toxicity.
期刊介绍：
Archives of Environmental & Occupational Health , originally founded in 1919 as the Journal of Industrial Hygiene, and perhaps most well-known as the Archives of Environmental Health, reports, integrates, and consolidates the latest research, both nationally and internationally, from fields germane to environmental health, including epidemiology, toxicology, exposure assessment, modeling and biostatistics, risk science and biochemistry. Publishing new research based on the most rigorous methods and discussion to put this work in perspective for public health, public policy, and sustainability, the Archives addresses such topics of current concern as health significance of chemical exposure, toxic waste, new and old energy technologies, industrial processes, and the environmental causation of disease such as neurotoxicity, birth defects, cancer, and chronic degenerative diseases. For more than 90 years, this noted journal has provided objective documentation of the effects of environmental agents on human and, in some cases, animal populations and information of practical importance on which decisions are based.
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