Sue-Ling Chang, André Tchernof, Francine Durocher, Caroline Diorio
{"title":"联合测量肥胖的女性乳腺脂肪组织中炎症和乳腺癌生物标志物的关联。","authors":"Sue-Ling Chang, André Tchernof, Francine Durocher, Caroline Diorio","doi":"10.1155/2021/3620147","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Mechanisms underlying the obesity-breast cancer link involve inflammation but need to be elucidated. Determining obesity by combining body mass index (BMI) with the waist circumference (WC) may clarify the role of inflammatory and hormonally related markers in breast cancer. We examined the effect of combining adiposity indices (BMI/WC) with the gene expression of several biomarkers involved in breast cancer.</p><p><strong>Methods: </strong>Expression of cytochrome P450 family 19 subfamily A member 1 (CYP19A1), estrogen receptor-alpha (ER-<i>α</i>), allograft inflammatory factor 1 (AIF1), cyclooxygenase-2 (COX2), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-<i>α</i>), and leptin (LEP) in 141 adipose breast tissues was quantified using qPCR method. BMI and WC were measured by a trained nurse and categorized using the median split, BMI<sup>LO</sup>WC<sup>LO</sup>, BMI<sup>LO</sup>WC<sup>HI</sup>, BMI<sup>HI</sup>WC<sup>LO</sup>, and BMI<sup>HI</sup>WC<sup>HI</sup>.</p><p><strong>Results: </strong>Gene expression of IL-6 (3-fold), TNF-<i>α</i> (2-fold), and LEP (2-fold) was higher in the breast adipose tissue of women with high WC regardless of BMI, that is, BMI<sup>LO</sup>WC<sup>HI</sup> and BMI<sup>HI</sup>WC<sup>HI</sup> women (all <i>P</i> < 0.01). Compared to BMI<sup>LO</sup>WC<sup>LO</sup> women, gene expression of CYP19A1, COX2, and AIF1 was increased by two-fold in breast adipose tissue of BMI<sup>HI</sup>WC<sup>HI</sup> women (<i>P</i> < 0.10). ER-<i>α</i> was not different across adiposity categories.</p><p><strong>Conclusions: </strong>The expression of some biomarkers, particularly those related to inflammation, is elevated in breast adipose tissue of women with a high WC independent of BMI. Obesity monitoring should also include women with normal or low BMI, but with central adiposity.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":" ","pages":"3620147"},"PeriodicalIF":4.3000,"publicationDate":"2021-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380177/pdf/","citationCount":"4","resultStr":"{\"title\":\"Associations of Biomarkers of Inflammation and Breast Cancer in the Breast Adipose Tissue of Women with Combined Measures of Adiposity.\",\"authors\":\"Sue-Ling Chang, André Tchernof, Francine Durocher, Caroline Diorio\",\"doi\":\"10.1155/2021/3620147\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Mechanisms underlying the obesity-breast cancer link involve inflammation but need to be elucidated. Determining obesity by combining body mass index (BMI) with the waist circumference (WC) may clarify the role of inflammatory and hormonally related markers in breast cancer. We examined the effect of combining adiposity indices (BMI/WC) with the gene expression of several biomarkers involved in breast cancer.</p><p><strong>Methods: </strong>Expression of cytochrome P450 family 19 subfamily A member 1 (CYP19A1), estrogen receptor-alpha (ER-<i>α</i>), allograft inflammatory factor 1 (AIF1), cyclooxygenase-2 (COX2), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-<i>α</i>), and leptin (LEP) in 141 adipose breast tissues was quantified using qPCR method. BMI and WC were measured by a trained nurse and categorized using the median split, BMI<sup>LO</sup>WC<sup>LO</sup>, BMI<sup>LO</sup>WC<sup>HI</sup>, BMI<sup>HI</sup>WC<sup>LO</sup>, and BMI<sup>HI</sup>WC<sup>HI</sup>.</p><p><strong>Results: </strong>Gene expression of IL-6 (3-fold), TNF-<i>α</i> (2-fold), and LEP (2-fold) was higher in the breast adipose tissue of women with high WC regardless of BMI, that is, BMI<sup>LO</sup>WC<sup>HI</sup> and BMI<sup>HI</sup>WC<sup>HI</sup> women (all <i>P</i> < 0.01). Compared to BMI<sup>LO</sup>WC<sup>LO</sup> women, gene expression of CYP19A1, COX2, and AIF1 was increased by two-fold in breast adipose tissue of BMI<sup>HI</sup>WC<sup>HI</sup> women (<i>P</i> < 0.10). ER-<i>α</i> was not different across adiposity categories.</p><p><strong>Conclusions: </strong>The expression of some biomarkers, particularly those related to inflammation, is elevated in breast adipose tissue of women with a high WC independent of BMI. 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Associations of Biomarkers of Inflammation and Breast Cancer in the Breast Adipose Tissue of Women with Combined Measures of Adiposity.
Background: Mechanisms underlying the obesity-breast cancer link involve inflammation but need to be elucidated. Determining obesity by combining body mass index (BMI) with the waist circumference (WC) may clarify the role of inflammatory and hormonally related markers in breast cancer. We examined the effect of combining adiposity indices (BMI/WC) with the gene expression of several biomarkers involved in breast cancer.
Methods: Expression of cytochrome P450 family 19 subfamily A member 1 (CYP19A1), estrogen receptor-alpha (ER-α), allograft inflammatory factor 1 (AIF1), cyclooxygenase-2 (COX2), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and leptin (LEP) in 141 adipose breast tissues was quantified using qPCR method. BMI and WC were measured by a trained nurse and categorized using the median split, BMILOWCLO, BMILOWCHI, BMIHIWCLO, and BMIHIWCHI.
Results: Gene expression of IL-6 (3-fold), TNF-α (2-fold), and LEP (2-fold) was higher in the breast adipose tissue of women with high WC regardless of BMI, that is, BMILOWCHI and BMIHIWCHI women (all P < 0.01). Compared to BMILOWCLO women, gene expression of CYP19A1, COX2, and AIF1 was increased by two-fold in breast adipose tissue of BMIHIWCHI women (P < 0.10). ER-α was not different across adiposity categories.
Conclusions: The expression of some biomarkers, particularly those related to inflammation, is elevated in breast adipose tissue of women with a high WC independent of BMI. Obesity monitoring should also include women with normal or low BMI, but with central adiposity.
期刊介绍:
ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric.
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