Won Young Jang, Su Nam Lee, Sung-Ho Her, Donggyu Moon, Keon-Woong Moon, Ki-Dong Yoo, Kyusup Lee, Ik Jun Choi, Jae Hwan Lee, Jang Hoon Lee, Sang Rok Lee, Seung-Wan Lee, Kyeong Ho Yun, Hyun-Jong Lee
{"title":"吸烟对接受钙化冠状动脉病变旋转动脉粥样硬化切除术患者临床结果的影响:来自韩国ROCK登记处。","authors":"Won Young Jang, Su Nam Lee, Sung-Ho Her, Donggyu Moon, Keon-Woong Moon, Ki-Dong Yoo, Kyusup Lee, Ik Jun Choi, Jae Hwan Lee, Jang Hoon Lee, Sang Rok Lee, Seung-Wan Lee, Kyeong Ho Yun, Hyun-Jong Lee","doi":"10.5144/0256-4947.2021.191","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Tobacco smoking and its harmful health effects also increase economic burdens globally. Surprisingly, despite the detrimental health consequences of smoking, some studies have shown better survival among smokers compared with non-smokers, a phenomenon called \"smoker's paradox\". However, the impact of smoking status on clinical outcomes in severe calcified coronary artery disease (CAD) patients has yet to be reported.</p><p><strong>Objectives: </strong>Investigate the impact of smoking on clinical outcomes in calcified CAD receiving rotational atherectomy (RA).</p><p><strong>Design: </strong>Retrospective review of medical records.</p><p><strong>Setting: </strong>Multicenter registry in South Korea.</p><p><strong>Patients and methods: </strong>This multicenter registry included consecutive patients with calcified CAD who underwent RA at nine tertiary centers in Korea between January 2010 and October 2019.</p><p><strong>Main outcome measures: </strong>Target-vessel failure (TVF) which included the composite of cardiac death, target-vessel myocardial infarction (TVMI), and target-vessel revascularization (TVR).</p><p><strong>Sample size: </strong>583 lesions in 540 patients followed for a median of 16.1 months.</p><p><strong>Results: </strong>Lesions were divided into two groups: non-smokers (n=472, 81.0%) and smokers (n=111, 19.0%). TVF in the smoker group was significantly more frequent than in non-smoker group (log rank <i>P</i>=.016). The inverse probability of treatment weighting analysis also showed that smoking was significantly associated with a higher incidence of the primary outcome (HR: 1.617; 95% CI: 1.127-2.320; <i>P</i>=.009), cardiac death (HR 1.912; 95% CI: 1.105-3.311; <i>P</i>=.021), myocardial infarction (HR: 3.914; 95% CI: 1.884-8.132; <i>P</i><.001), TVMI (HR: 3.234; 95% CI: 1.130-9.258; <i>P</i>=.029), and TVR (HR: 1.661; 95% CI: 1.043-2.643; <i>P</i>=.032). However, any bleeding was significantly observed less in the smokers.</p><p><strong>Conclusion: </strong>Smoking is significantly associated with adverse clinical outcomes in CAD patients requiring RA.</p><p><strong>Limitations: </strong>Retrospective design.</p><p><strong>Conflicts of interest: </strong>None.</p>","PeriodicalId":8016,"journal":{"name":"Annals of Saudi Medicine","volume":"41 4","pages":"191-197"},"PeriodicalIF":1.5000,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/89/0256-4947.2021.191.PMC8380281.pdf","citationCount":"0","resultStr":"{\"title\":\"Effect of smoking on clinical outcomes in patients receiving rotational atherectomy in calcified coronary lesions: from the ROCK Registry, South Korea.\",\"authors\":\"Won Young Jang, Su Nam Lee, Sung-Ho Her, Donggyu Moon, Keon-Woong Moon, Ki-Dong Yoo, Kyusup Lee, Ik Jun Choi, Jae Hwan Lee, Jang Hoon Lee, Sang Rok Lee, Seung-Wan Lee, Kyeong Ho Yun, Hyun-Jong Lee\",\"doi\":\"10.5144/0256-4947.2021.191\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Tobacco smoking and its harmful health effects also increase economic burdens globally. Surprisingly, despite the detrimental health consequences of smoking, some studies have shown better survival among smokers compared with non-smokers, a phenomenon called \\\"smoker's paradox\\\". However, the impact of smoking status on clinical outcomes in severe calcified coronary artery disease (CAD) patients has yet to be reported.</p><p><strong>Objectives: </strong>Investigate the impact of smoking on clinical outcomes in calcified CAD receiving rotational atherectomy (RA).</p><p><strong>Design: </strong>Retrospective review of medical records.</p><p><strong>Setting: </strong>Multicenter registry in South Korea.</p><p><strong>Patients and methods: </strong>This multicenter registry included consecutive patients with calcified CAD who underwent RA at nine tertiary centers in Korea between January 2010 and October 2019.</p><p><strong>Main outcome measures: </strong>Target-vessel failure (TVF) which included the composite of cardiac death, target-vessel myocardial infarction (TVMI), and target-vessel revascularization (TVR).</p><p><strong>Sample size: </strong>583 lesions in 540 patients followed for a median of 16.1 months.</p><p><strong>Results: </strong>Lesions were divided into two groups: non-smokers (n=472, 81.0%) and smokers (n=111, 19.0%). TVF in the smoker group was significantly more frequent than in non-smoker group (log rank <i>P</i>=.016). The inverse probability of treatment weighting analysis also showed that smoking was significantly associated with a higher incidence of the primary outcome (HR: 1.617; 95% CI: 1.127-2.320; <i>P</i>=.009), cardiac death (HR 1.912; 95% CI: 1.105-3.311; <i>P</i>=.021), myocardial infarction (HR: 3.914; 95% CI: 1.884-8.132; <i>P</i><.001), TVMI (HR: 3.234; 95% CI: 1.130-9.258; <i>P</i>=.029), and TVR (HR: 1.661; 95% CI: 1.043-2.643; <i>P</i>=.032). However, any bleeding was significantly observed less in the smokers.</p><p><strong>Conclusion: </strong>Smoking is significantly associated with adverse clinical outcomes in CAD patients requiring RA.</p><p><strong>Limitations: </strong>Retrospective design.</p><p><strong>Conflicts of interest: </strong>None.</p>\",\"PeriodicalId\":8016,\"journal\":{\"name\":\"Annals of Saudi Medicine\",\"volume\":\"41 4\",\"pages\":\"191-197\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2021-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/89/0256-4947.2021.191.PMC8380281.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Saudi Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5144/0256-4947.2021.191\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/8/22 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Saudi Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5144/0256-4947.2021.191","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/8/22 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Effect of smoking on clinical outcomes in patients receiving rotational atherectomy in calcified coronary lesions: from the ROCK Registry, South Korea.
Background: Tobacco smoking and its harmful health effects also increase economic burdens globally. Surprisingly, despite the detrimental health consequences of smoking, some studies have shown better survival among smokers compared with non-smokers, a phenomenon called "smoker's paradox". However, the impact of smoking status on clinical outcomes in severe calcified coronary artery disease (CAD) patients has yet to be reported.
Objectives: Investigate the impact of smoking on clinical outcomes in calcified CAD receiving rotational atherectomy (RA).
Design: Retrospective review of medical records.
Setting: Multicenter registry in South Korea.
Patients and methods: This multicenter registry included consecutive patients with calcified CAD who underwent RA at nine tertiary centers in Korea between January 2010 and October 2019.
Main outcome measures: Target-vessel failure (TVF) which included the composite of cardiac death, target-vessel myocardial infarction (TVMI), and target-vessel revascularization (TVR).
Sample size: 583 lesions in 540 patients followed for a median of 16.1 months.
Results: Lesions were divided into two groups: non-smokers (n=472, 81.0%) and smokers (n=111, 19.0%). TVF in the smoker group was significantly more frequent than in non-smoker group (log rank P=.016). The inverse probability of treatment weighting analysis also showed that smoking was significantly associated with a higher incidence of the primary outcome (HR: 1.617; 95% CI: 1.127-2.320; P=.009), cardiac death (HR 1.912; 95% CI: 1.105-3.311; P=.021), myocardial infarction (HR: 3.914; 95% CI: 1.884-8.132; P<.001), TVMI (HR: 3.234; 95% CI: 1.130-9.258; P=.029), and TVR (HR: 1.661; 95% CI: 1.043-2.643; P=.032). However, any bleeding was significantly observed less in the smokers.
Conclusion: Smoking is significantly associated with adverse clinical outcomes in CAD patients requiring RA.
期刊介绍：
The Annals of Saudi Medicine (ASM) is published bimonthly by King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. We publish scientific reports of clinical interest in English. All submissions are subject to peer review by the editorial board and by reviewers in appropriate specialties. The journal will consider for publication manuscripts from any part of the world, but particularly reports that would be of interest to readers in the Middle East or other parts of Asia and Africa. Please go to the Author Resource Center for additional information.
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