小檗碱通过调节胰岛代谢应激下的自噬，重塑局部肾素-血管紧张素系统的平衡。

IF 2.1 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2021-08-03 eCollection Date: 2021-01-01 DOI:10.1155/2021/9928986

Chenghu Huang, Pan Lei, Caibi Peng, Min Li, Yifei Guo, Xuefeng Li

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引用次数: 1

摘要

结果:长时间暴露于棕榈酸盐可增加ACE和AngII型1受体(ATR1)的表达，降低ACE2的表达，而黄连素可部分抵消ACE2的表达。在ob/ob小鼠中，小檗碱增加葡萄糖耐受性，改善异常β细胞和α细胞分布，上调ACE2表达，降低自噬体和LC3、SQSTM1/p62的表达。ACE2KO小鼠的自噬体和LC3、SQSTM1/p62的表达增加。结论:我们证明了小檗碱可能通过调节代谢应激下ras介导的局部自噬来改善胰岛功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets.

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Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets.

Results: Prolonged exposure to palmitate increased the expression of ACE and AngII type 1 receptor (ATR1) and decreased the ACE2 expression, which was partly offset by berberine. In ob/ob mice, berberine increased in tolerance to glucose, improved abnormal β-cell and α-cell distributions, upregulated ACE2 expression, and decreased autophagosomes and the expression of LC3 and SQSTM1/p62. Autophagosomes and expression of LC3 and SQSTM1/p62 were increased in ACE2KO mice.

Conclusions: We demonstrated that berberine may improve the pancreatic islet function by regulating local RAS-mediated autophagy under metabolic stress.

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来源期刊

Journal of the Renin-Angiotensin-Aldosterone System 医学-外周血管病

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.