Kara Manning, Andrew H Rogers, Lorra Garey, Michael J Zvolensky
{"title":"慢性腰痛患者疲劳敏感性在抑郁与酒精和阿片类药物滥用关系中的调节作用","authors":"Kara Manning, Andrew H Rogers, Lorra Garey, Michael J Zvolensky","doi":"10.1080/21641846.2020.1818933","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Chronic low back pain is the second leading cause of disability in the United States and is frequently related to increased risk of opioid and alcohol misuse. Depression is associated with poor substance use outcomes among persons with chronic low back pain. Theoretically, the influence of depression on opioid and alcohol misuse among those with chronic low back pain may vary as a function of fatigue sensitivity.</p><p><strong>Method: </strong>To empirically test this theorized model, the current study examined fatigue sensitivity as a moderator for the relation between depression and opioid and alcohol misuse among 291 adults (69.1% female, <i>M</i> <sub><i>age</i></sub> <i>=</i> 45.77 years, <i>SD</i> = 11.22) with chronic low back pain currently using opioids.</p><p><strong>Results: </strong>Results suggested that fatigue sensitivity moderated the effect of depression on opioid misuse (β=0.60, <i>p</i>= .001, 95%CI [0.02, 0.06]) and alcohol misuse (β=0.45, <i>p</i>= .025, 95%CI [0.002, 0.03]). Examination of simple slopes revealed that the association between depression and opioid and alcohol misuse was statistically significant for those with higher levels of fatigue sensitivity, but not lower levels of fatigue sensitivity.</p><p><strong>Conclusions: </strong>Overall, the current investigation provides initial empirical support for the moderating role of fatigue sensitivity in the relation between depression and alcohol and opioid misuse among adults with chronic low back pain.</p>","PeriodicalId":44745,"journal":{"name":"Fatigue-Biomedicine Health and Behavior","volume":"8 3","pages":"130-143"},"PeriodicalIF":2.2000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21641846.2020.1818933","citationCount":"2","resultStr":"{\"title\":\"The Moderating Role of Fatigue Sensitivity in the Relation between Depression and Alcohol and Opioid Misuse among Adults with Chronic Low Back Pain.\",\"authors\":\"Kara Manning, Andrew H Rogers, Lorra Garey, Michael J Zvolensky\",\"doi\":\"10.1080/21641846.2020.1818933\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Chronic low back pain is the second leading cause of disability in the United States and is frequently related to increased risk of opioid and alcohol misuse. Depression is associated with poor substance use outcomes among persons with chronic low back pain. Theoretically, the influence of depression on opioid and alcohol misuse among those with chronic low back pain may vary as a function of fatigue sensitivity.</p><p><strong>Method: </strong>To empirically test this theorized model, the current study examined fatigue sensitivity as a moderator for the relation between depression and opioid and alcohol misuse among 291 adults (69.1% female, <i>M</i> <sub><i>age</i></sub> <i>=</i> 45.77 years, <i>SD</i> = 11.22) with chronic low back pain currently using opioids.</p><p><strong>Results: </strong>Results suggested that fatigue sensitivity moderated the effect of depression on opioid misuse (β=0.60, <i>p</i>= .001, 95%CI [0.02, 0.06]) and alcohol misuse (β=0.45, <i>p</i>= .025, 95%CI [0.002, 0.03]). Examination of simple slopes revealed that the association between depression and opioid and alcohol misuse was statistically significant for those with higher levels of fatigue sensitivity, but not lower levels of fatigue sensitivity.</p><p><strong>Conclusions: </strong>Overall, the current investigation provides initial empirical support for the moderating role of fatigue sensitivity in the relation between depression and alcohol and opioid misuse among adults with chronic low back pain.</p>\",\"PeriodicalId\":44745,\"journal\":{\"name\":\"Fatigue-Biomedicine Health and Behavior\",\"volume\":\"8 3\",\"pages\":\"130-143\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/21641846.2020.1818933\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fatigue-Biomedicine Health and Behavior\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/21641846.2020.1818933\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/9/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fatigue-Biomedicine Health and Behavior","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21641846.2020.1818933","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/9/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
The Moderating Role of Fatigue Sensitivity in the Relation between Depression and Alcohol and Opioid Misuse among Adults with Chronic Low Back Pain.
Objective: Chronic low back pain is the second leading cause of disability in the United States and is frequently related to increased risk of opioid and alcohol misuse. Depression is associated with poor substance use outcomes among persons with chronic low back pain. Theoretically, the influence of depression on opioid and alcohol misuse among those with chronic low back pain may vary as a function of fatigue sensitivity.
Method: To empirically test this theorized model, the current study examined fatigue sensitivity as a moderator for the relation between depression and opioid and alcohol misuse among 291 adults (69.1% female, Mage= 45.77 years, SD = 11.22) with chronic low back pain currently using opioids.
Results: Results suggested that fatigue sensitivity moderated the effect of depression on opioid misuse (β=0.60, p= .001, 95%CI [0.02, 0.06]) and alcohol misuse (β=0.45, p= .025, 95%CI [0.002, 0.03]). Examination of simple slopes revealed that the association between depression and opioid and alcohol misuse was statistically significant for those with higher levels of fatigue sensitivity, but not lower levels of fatigue sensitivity.
Conclusions: Overall, the current investigation provides initial empirical support for the moderating role of fatigue sensitivity in the relation between depression and alcohol and opioid misuse among adults with chronic low back pain.
期刊介绍：
Fatigue: Biomedicine, Health and Behavior is an international, interdisciplinary journal that addresses the symptom of fatigue in medical illnesses, behavioral disorders, and specific environmental conditions. These broadly conceived domains, all housed in one journal, are intended to advance research on causation, pathophysiology, assessment, and treatment. The list of topics covered in Fatigue will include fatigue in diseases including cancer, autoimmune diseases, multiple sclerosis, pain conditions, mood disorders, and circulatory diseases. The journal will also publish papers on chronic fatigue syndrome, fibromyalgia and related illnesses. In addition, submissions on specific issues involving fatigue in sleep, aging, exercise and sport, and occupations are welcomed. More generally, the journal will publish on the biology, physiology and psychosocial aspects of fatigue. The Editor also welcomes new topics such as clinical fatigue education in medical schools and public health policy with respect to fatigue.
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