探讨CR1基因变异在晚发性阿尔茨海默病易感性中的作用。

IF 1.5 4区医学 Q4 GENETICS & HEREDITY

Psychiatric Genetics Pub Date : 2021-12-01 DOI:10.1097/YPG.0000000000000291

Liu Lu, Qing-Yu Yao, Sha-Sha Ruan, Jia-Wei Hu, Wen-Jun Long, Wen-Zhuo Dai, Tao Ma, Xi-Chen Zhu

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引用次数: 2

摘要

背景：补体成分（3b/4b）受体1（CR1）是一个有趣的候选基因，与阿尔茨海默病密切相关，其多态性已被报道与晚发性阿尔茨海默病（LOAD）易感性有关。然而，这些相关研究的结果并不一致。目的探讨CR1基因变异对LOAD易感性的影响。方法检索截至2020年11月1日的相关研究。比值比（OR）及其95%置信区间（CI）用于评估相关性的强度。此外，我们进行了一项病例对照关联研究，以评估他们的遗传关联。结果：最后，共纳入30篇文章，30108例LOAD病例和37895例对照。在LOAD患者和对照组rs3818361和rs6656401中观察到显著的等位基因频率（rs381836 1，T vs.C:OR，1.18；95%CI，1.13-1.23；rs665640 1，A vs.G:OR，1.23；95%置信区间，1.10-1.36）。此外，这些结果在亚洲或美洲的rs381836l亚组中仍然显著（OR，1.26；95%置信度，1.06-1.45；OR，分别为1.18；95%CI，1.13-1.24）和欧洲的rs665640l（OR = 1.26；95%可信区间，1.09-1.42）。此外，在显性模型下，两个单核苷酸多态性被证明显著增加了整体人群的负荷风险（OR = 1.12；95%可信区间1.02-1.21；或 = 1.18，95%CI，1.15-1.22）。病例对照研究显示rs6656401基因型分布显著（P = 0.000；或6.889；95%可信区间2.709-17.520），表明rs6656401的A等位基因是危险等位基因。结论：这些现有数据表明，CR1中的rs6656401显著增加LOAD风险。

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Explore the role of CR1 genetic variants in late-onset Alzheimer's disease susceptibility.

Background: Complement component (3b/4b) receptor 1 (CR1) is an interesting candidate gene which has a close connection with Alzheimer's disease, and its polymorphisms have been reported to link to the late-onset Alzheimer's disease (LOAD) susceptibility. However, the findings of these related studies are inconsistent. Objective To explore the effect of CR1 genetic variants in LOAD susceptibility. MethodsWe searched relevant studies for the period up to 1 November 2020. And odds ratios (ORs) and their 95% confidence intervals (CIs) were utilized to assess the strength of the association. In addition, we carried out a case-control association study to assess their genetic association.

Results: Finally, a total of 30 articles with 30108 LOAD cases and 37895 controls were included. Significant allele frequency between LOAD patients and controls was observed in rs3818361 and rs6656401 (rs3818361, T vs. C: OR,1.18; 95% CI, 1.13-1.23; rs6656401, A vs. G: OR, 1.23; 95% CI, 1.10-1.36). Moreover, these results remain significant in subgroup of rs3818361 in Asia or America (OR,1.26; 95% CI,1.06-1.45; OR, 1.18; 95% CI, 1.13-1.24, respectively) and rs6656401 in Europe (OR = 1.26; 95% CI, 1.09-1.42). In addition, the two single nucleotide polymorphisms were proved to significantly increase LOAD risk in the overall population under the dominant model (OR = 1.12; 95% CI, 1.02-1.21; OR = 1.18, 95% CI, 1.15-1.22, respectively). Our case-control study showed that the distribution of rs6656401 genotype was significant (P = 0.000; OR, 6.889; 95% CI, 2.709-17.520), suggesting the A allele of rs6656401 is the risk allele.

Conclusion: These available data indicate that rs6656401 in CR1 is significant to increase LOAD risk.

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.