药物化学的自动化和使能技术。

Q1 Pharmacology, Toxicology and Pharmaceutics

Progress in medicinal chemistry Pub Date : 2021-01-01 Epub Date: 2021-06-07 DOI:10.1016/bs.pmch.2021.01.003

Paula L Nichols

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引用次数: 1

摘要

药物发现是一个不断发展的过程，一直受到尽快为患者提供新疗法的需求的推动。本章将回顾药物化学是如何建立的，多年来由于新的使能技术的出现而发生了怎样的变化，以及合成、纯化和分析的早期进展如何为当前自动化和使能技术的建立提供了基础。除了已建立的技术之外，本章还将考虑现在正在出现的技术，以及它们对药物发现的未来和药物化学家的作用的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Automated and enabling technologies for medicinal chemistry.

Having always been driven by the need to get new treatments to patients as quickly as possible, drug discovery is a constantly evolving process. This chapter will review how medicinal chemistry was established, how it has changed over the years due to the emergence of new enabling technologies, and how early advances in synthesis, purification and analysis, have provided the foundations upon which the current automated and enabling technologies are built. Looking beyond the established technologies, this chapter will also consider technologies that are now emerging, and their impact on the future of drug discovery and the role of medicinal chemists.

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来源期刊

Progress in medicinal chemistry Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

15.60

自引率

0.00%

发文量

期刊介绍： This series has a long established reputation for excellent coverage of almost every facet of Medicinal Chemistry and is one of the most respected and instructive sources of information on the subject. The latest volume certifies to the continuing success of a unique series reflecting current progress in a broadly developing field of science.