Miguel Ángel Fernández-Barrera, Adriana Fernandes da Silva, América Patricia Pontigo-Loyola, J Eliezer Zamarripa-Calderón, Evandro Piva, Carlos Enrique Cuevas-Suárez
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引用次数: 5
摘要
目的:系统回顾文献，评价脱蛋白剂是否影响树脂基材料与牙釉质的结合强度。材料和方法:本系统综述和荟萃分析按照PRISMA声明进行。PubMed、ISI Web of Science、Cochrane Library、SciELO、Scopus、LILACS、IBECS和BVS数据库的筛选截止到2020年12月。资格标准包括体外研究，这些研究报告了在酸蚀之前或之后应用脱蛋白剂对树脂基材料与牙釉质的即时或长期结合强度的影响。meta分析使用Review Manager(5.3.5版本)进行。采用基于随机效应模型的标准化均差进行全局比较，显著性水平为α = 0.05。结果:meta分析共纳入23项研究。在所有的研究中，只评估了直接粘结强度。磷酸刻蚀前应用NaOCl或木瓜蛋白酶可提高材料的结合强度(p≤0.006)。磷酸蚀刻后应用脱蛋白剂均无显著效果(p≥0.27)。结论:根据体外研究，只有在磷酸蚀刻之前使用次氯酸钠或木瓜蛋白酶脱蛋白才能增加树脂基材料与牙釉质的直接结合强度。
The Effect of Deproteinizing Agents on Bond Strength of Resin-based Materials to Enamel: A Systematic Review and Meta-Analysis of In Vitro Studies.
Purpose: To systematically review the literature to evaluate whether the bond strength of resin-based materials to enamel is affected by deproteinizing agents.
Materials and methods: This systematic review and meta-analysis was conducted according to the PRISMA statement. PubMed, ISI Web of Science, Cochrane Library, SciELO, Scopus, LILACS, IBECS, and BVS databases were screened up to December 2020. Eligibility criteria included in vitro studies that reported the effect of a deproteinizing agent applied before or after acid etching on the immediate or long-term bond strength of resin-based materials to enamel. The meta-analysis was carried out using Review Manager (version 5.3.5). A global comparison was performed with the standardized mean difference based on random-effect models at a significance level of α = 0.05.
Results: A total of 23 studies were included in the meta-analysis. In all the studies, only the immediate bond strength was evaluated. The bond strength of the materials was improved by the application of NaOCl or papain prior to enamel etching with phosphoric acid (p ≤ 0.006). None of the deproteinizing agents had a significant effect when applied after etching with phosphoric acid (p ≥ 0.27).
Conclusions: Based on in vitro studies, deproteinization with sodium hypochlorite or papain-based agents increases the immediate bond strength of resin-based materials to enamel only when used prior to phosphoric-acid etching.
期刊介绍：
New materials and applications for adhesion are profoundly changing the way dentistry is delivered. Bonding techniques, which have long been restricted to the tooth hard tissues, enamel, and dentin, have obvious applications in operative and preventive dentistry, as well as in esthetic and pediatric dentistry, prosthodontics, and orthodontics. The current development of adhesive techniques for soft tissues and slow-releasing agents will expand applications to include periodontics and oral surgery. Scientifically sound, peer-reviewed articles explore the latest innovations in these emerging fields.
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