{"title":"早产儿视网膜病变:一项基于新生儿和产妇危险因素的系统回顾和荟萃分析研究。","authors":"Tahereh Bahmani, Arezoo Karimi, Nazanin Rezaei, Salman Daliri","doi":"10.1080/14767058.2021.1940938","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Retinopathy of prematurity is the abnormal development of retinal arteries in preterm neonates less than 32 weeks and weighing 1500 g, and less, which can lead to visual impairment during life and blindness. This study aims to investigate the relationship between some clinical characteristics of neonates and mothers with Retinopathy of prematurity in the world <i>via</i> a systematic review and meta-analysis.</p><p><strong>Materials and methods: </strong>The present study is a systematic review and meta-analysis on the relationship between maternal and neonatal clinical variables with Retinopathy of prematurity in the world from the beginning of 2000 to the end of 2020. Accordingly, all English articles published on the topic were searched in scientific databases of Web of Science, PubMed, Google Scholar, Science Direct, and Scopus. The articles were searched independently by two researchers. Statistical analysis of data was performed using fixed and random effects model statistical tests in the meta-analysis, Cochran, meta-regression, <i>I<sup>2</sup></i> index, Funnel plot, and Begg's by STATA software program, version 14.</p><p><strong>Result: </strong>A total of 191 studies with a sample size of 140,921 persons were including in the meta-analysis. Accordingly, Preterm delivery ≤28 weeks (OR:6.3, 95% CI:4.9-8.1), Birth Weight ≤1000 g (OR:5.8, 95% CI:4.8-6.8), Birth Weight ≤1500 g (OR:4.8, 95% CI:3.8-6.1), PROM (OR:1.2, 95% CI:1.0-1.4), induced fertility (OR:1.9, 95% CI:1.1-3.0) and Chorioamnionitis (OR:1.5, 95% CI:1.0-2.2) There was a statistically significant association with retinopathy.</p><p><strong>Conclusion: </strong>Based on the results of the present meta-analysis, the risk of retinopathy of prematurity in neonates born at 28 weeks and less, LBW (weight 1500 g and less), neonatal hypotension, chorioamnionitis, and induced fertility increases.</p>","PeriodicalId":520807,"journal":{"name":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","volume":" ","pages":"8032-8050"},"PeriodicalIF":0.0000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Retinopathy prematurity: a systematic review and meta-analysis study based on neonatal and maternal risk factors.\",\"authors\":\"Tahereh Bahmani, Arezoo Karimi, Nazanin Rezaei, Salman Daliri\",\"doi\":\"10.1080/14767058.2021.1940938\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Retinopathy of prematurity is the abnormal development of retinal arteries in preterm neonates less than 32 weeks and weighing 1500 g, and less, which can lead to visual impairment during life and blindness. This study aims to investigate the relationship between some clinical characteristics of neonates and mothers with Retinopathy of prematurity in the world <i>via</i> a systematic review and meta-analysis.</p><p><strong>Materials and methods: </strong>The present study is a systematic review and meta-analysis on the relationship between maternal and neonatal clinical variables with Retinopathy of prematurity in the world from the beginning of 2000 to the end of 2020. Accordingly, all English articles published on the topic were searched in scientific databases of Web of Science, PubMed, Google Scholar, Science Direct, and Scopus. The articles were searched independently by two researchers. Statistical analysis of data was performed using fixed and random effects model statistical tests in the meta-analysis, Cochran, meta-regression, <i>I<sup>2</sup></i> index, Funnel plot, and Begg's by STATA software program, version 14.</p><p><strong>Result: </strong>A total of 191 studies with a sample size of 140,921 persons were including in the meta-analysis. Accordingly, Preterm delivery ≤28 weeks (OR:6.3, 95% CI:4.9-8.1), Birth Weight ≤1000 g (OR:5.8, 95% CI:4.8-6.8), Birth Weight ≤1500 g (OR:4.8, 95% CI:3.8-6.1), PROM (OR:1.2, 95% CI:1.0-1.4), induced fertility (OR:1.9, 95% CI:1.1-3.0) and Chorioamnionitis (OR:1.5, 95% CI:1.0-2.2) There was a statistically significant association with retinopathy.</p><p><strong>Conclusion: </strong>Based on the results of the present meta-analysis, the risk of retinopathy of prematurity in neonates born at 28 weeks and less, LBW (weight 1500 g and less), neonatal hypotension, chorioamnionitis, and induced fertility increases.</p>\",\"PeriodicalId\":520807,\"journal\":{\"name\":\"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians\",\"volume\":\" \",\"pages\":\"8032-8050\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/14767058.2021.1940938\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/7/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14767058.2021.1940938","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/7/13 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
摘要
背景:早产儿视网膜病变是指小于32周、体重在1500g及以下的早产儿视网膜动脉发育异常,可导致终身视力障碍和失明。本研究旨在通过系统综述和荟萃分析的方法,探讨世界范围内新生儿的一些临床特征与早产儿视网膜病变母亲之间的关系。材料与方法:本研究对2000年初至2020年底全球早产儿视网膜病变与孕产妇和新生儿临床变量的关系进行系统回顾和荟萃分析。因此,在Web of Science、PubMed、Google Scholar、Science Direct和Scopus等科学数据库中检索了所有与该主题相关的英文文章。这些文章是由两名研究人员独立检索的。数据的统计分析采用固定效应和随机效应模型统计检验进行meta分析、Cochran、meta回归、I2指数、Funnel图和Begg's,采用STATA软件程序,版本14。结果:荟萃分析共纳入191项研究,样本量为140,921人。因此,早产≤28周(OR:6.3, 95% CI:4.9-8.1)、出生体重≤1000 g (OR:5.8, 95% CI:4.8-6.8)、出生体重≤1500 g (OR:4.8, 95% CI:3.8-6.1)、胎膜早PROM (OR:1.2, 95% CI:1.0-1.4)、诱导生育(OR:1.9, 95% CI:1.1-3.0)和绒毛膜羊膜炎(OR:1.5, 95% CI:1.0-2.2)与视网膜病变有统计学意义的关联。结论:基于本荟萃分析的结果,28周及以下出生的早产儿视网膜病变、LBW(体重1500 g及以下)、新生儿低血压、绒毛膜羊膜炎和诱导生育的风险增加。
Retinopathy prematurity: a systematic review and meta-analysis study based on neonatal and maternal risk factors.
Background: Retinopathy of prematurity is the abnormal development of retinal arteries in preterm neonates less than 32 weeks and weighing 1500 g, and less, which can lead to visual impairment during life and blindness. This study aims to investigate the relationship between some clinical characteristics of neonates and mothers with Retinopathy of prematurity in the world via a systematic review and meta-analysis.
Materials and methods: The present study is a systematic review and meta-analysis on the relationship between maternal and neonatal clinical variables with Retinopathy of prematurity in the world from the beginning of 2000 to the end of 2020. Accordingly, all English articles published on the topic were searched in scientific databases of Web of Science, PubMed, Google Scholar, Science Direct, and Scopus. The articles were searched independently by two researchers. Statistical analysis of data was performed using fixed and random effects model statistical tests in the meta-analysis, Cochran, meta-regression, I2 index, Funnel plot, and Begg's by STATA software program, version 14.
Result: A total of 191 studies with a sample size of 140,921 persons were including in the meta-analysis. Accordingly, Preterm delivery ≤28 weeks (OR:6.3, 95% CI:4.9-8.1), Birth Weight ≤1000 g (OR:5.8, 95% CI:4.8-6.8), Birth Weight ≤1500 g (OR:4.8, 95% CI:3.8-6.1), PROM (OR:1.2, 95% CI:1.0-1.4), induced fertility (OR:1.9, 95% CI:1.1-3.0) and Chorioamnionitis (OR:1.5, 95% CI:1.0-2.2) There was a statistically significant association with retinopathy.
Conclusion: Based on the results of the present meta-analysis, the risk of retinopathy of prematurity in neonates born at 28 weeks and less, LBW (weight 1500 g and less), neonatal hypotension, chorioamnionitis, and induced fertility increases.