膀胱浆母细胞淋巴瘤引起的轻链铸型肾病。

Clinical Nephrology. Case Studies Pub Date : 2021-07-01 eCollection Date: 2021-01-01 DOI:10.5414/CNCS110339
Mehrian Jafarizade, Kiran Goli, Vivette D'Agati, Essel Dulaimi, Krupa Daniel, Bradley Lash, Sharon Maynard
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引用次数: 3

摘要

浆母细胞淋巴瘤(PBL)是一种罕见的b细胞淋巴瘤,常见于潜在免疫抑制的患者,如HIV、自身免疫性疾病和器官移植。hiv阳性患者的PBL通常起源于胃肠道,以口腔为主。PBL累及膀胱极为罕见,由κ轻链分泌PBL引起的铸型肾病也未见报道。病例报告:我们报告了一个病人谁提出了急性肾损伤(AKI)在设置艾滋病毒,并被发现有膀胱肿瘤。膀胱病理显示高级别PBL伴κ轻链限制。肾活检显示κ轻链铸型肾病,可能继发于分泌κ轻链的PBL。结论:虽然PBL的预后很差,但我们的患者从AKI中恢复过来,通过化疗获得了完全的血液学缓解,并成功进行了自体干细胞移植。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Light chain cast nephropathy caused by plasmablastic lymphoma of the bladder.

Light chain cast nephropathy caused by plasmablastic lymphoma of the bladder.

Light chain cast nephropathy caused by plasmablastic lymphoma of the bladder.

Introduction: Plasmablastic lymphoma (PBL) is a rare form of B-cell lymphoma typically seen in patients with underlying immunosuppression such as HIV, autoimmune disease, and organ transplantation. PBL in HIV-positive patients usually originates from the gastrointestinal tract, with a predilection for the oral cavity. Bladder involvement by PBL is exceedingly rare, and cast nephropathy due to κ light chain-secreting PBL has not been reported previously.

Case report: We report a patient who presented with acute kidney injury (AKI) in the setting of HIV, and was found to have a bladder tumor. Bladder pathology revealed a high-grade PBL with κ light chain restriction. Renal biopsy showed κ light chain cast nephropathy, presumably secondary to κ light chain-secreting PBL.

Conclusion: Although the prognosis of PBL is poor, our patient recovered from AKI, achieved complete hematologic remission with chemotherapy, and underwent successful autologous stem cell transplant.

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