膳食褪黑素和Omega-3脂肪酸通过抑制亚油酸的摄取和代谢,诱导体内大鼠癌症异种移植物消退。

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Comparative medicine Pub Date : 2021-08-01 Epub Date: 2021-06-29 DOI:10.30802/AALAS-CM-21-000025
Erin M Dauchy, Robert T Dauchy, Robert P Tirrell, Leslie K Davidson, Steven M Hill, Leonard A Sauer, David E Blask
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引用次数: 1

摘要

褪黑激素,昼夜节律夜间神经激素,二十碳五烯酸(EPA)和二十二碳六烯酸(DHA),即鱼油(FO)和植物中高浓度的omega-3脂肪酸(FA),在体内消除了亚油酸(LA),一种omega-6 FA,对啮齿动物肿瘤和人类乳腺癌、前列腺癌、头颈部鳞状细胞癌(HNSCC)异种移植物生长的致癌作用。在此,我们测定并比较了这些抑制剂对人前列腺癌3 (PC3)和FaDu HNSCC异种移植瘤雄性裸鼠肿瘤消退和LA摄取和代谢的长期影响。试验大鼠分为3组,分别饲喂含5%玉米油(CO,高LA)、5% CO油和褪黑素(2 μg/mL)的饲粮和5% FO(低LA)的替代饲粮。饮食中含有褪黑素的大鼠的PC3前列腺癌异种移植物的消退速度比接受鱼油饮食的大鼠快,而褪黑素组和鱼油组诱导HNSCC异种移植物的消退速度相同。结果还表明,膳食摄入褪黑素或鱼油可显著抑制肿瘤LA摄取、cAMP含量、13-[S]- hode形成、[³H]-胸腺嘧啶并入肿瘤DNA以及肿瘤DNA含量。因此,长期摄入褪黑素或FO均可通过抑制肿瘤细胞对LA的摄取和代谢的机制诱导PC3前列腺和HNSCC异种移植物的退化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Dietary Melatonin and Omega-3 Fatty Acids Induce Human Cancer Xenograft Regression In Vivo in Rats by Suppressing Linoleic Acid Uptake and Metabolism.

Dietary Melatonin and Omega-3 Fatty Acids Induce Human Cancer Xenograft Regression In Vivo in Rats by Suppressing Linoleic Acid Uptake and Metabolism.

Dietary Melatonin and Omega-3 Fatty Acids Induce Human Cancer Xenograft Regression In Vivo in Rats by Suppressing Linoleic Acid Uptake and Metabolism.

Melatonin, the circadian nighttime neurohormone, and eicosapentaenoic acid (EPA) and docosahexaenoic acids (DHA), which are omega-3 fatty acids (FA) found in high concentrations in fish oil (FO) and plants, abrogate the oncogenic effects of linoleic acid (LA), an omega-6 FA, on the growth of rodent tumors and human breast, prostate, and head and neck squamous cell carcinoma (HNSCC) xenografts in vivo. Here we determined and compared the long-term effects of these inhibitory agents on tumor regression and LA uptake and metabolism to the mitogenic agent 13-[S]-hydroxyoctadecadienoic acid (13-[S]-HODE) in human prostate cancer 3 (PC3) and FaDu HNSCC xenografts in tumor-bearing male nude rats. Rats in this study were split into 3 groups and fed one of 2 diets: one diet containing 5% corn oil (CO, high LA), 5% CO oil and melatonin (2 μg/mL) or an alternative diet 5% FO (low LA). Rats whose diet contained melatonin had a faster rate of regression of PC3 prostate cancer xenografts than those receiving the FO diet, while both in the melatonin and FO groups induced the same rate of regression of HNSCC xenografts. The results also demonstrated that dietary intake of melatonin or FO significantly inhibited tumor LA uptake, cAMP content, 13-[S]-HODE formation, [³H]-thymidine incorporation into tumor DNA, and tumor DNA content. Therefore, long-term ingestion of either melatonin or FO can induce regression of PC3 prostate and HNSCC xenografts via a mechanism involving the suppression of LA uptake and metabolism by the tumor cells.

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来源期刊
Comparative medicine
Comparative medicine 医学-动物学
CiteScore
1.90
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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