健康成年男性的循环脂肪连接蛋白和抵抗素水平与肥胖指数和体能有关。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-06-23

Syed Shahid Habib, Mamoona Sultan, Adeena Khan, Thamir Al-Khlaiwi, Shahid Bashir

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Based on ideal body composition, PFS were computed as previously published for all subjects and compared with serum markers. RESULTS There was a positive correlation of adiponectin with PFS (r=.218, p=0.015) and an inverse correlation with obesity degree (OD), OD (r=-.239, p=0.001), body mass index (BMI) (r=-.244, p=0.001), and waist/hip ratio (WHR) WHR (r=-.296, p=0.001). Moreover, it was correlated negatively with basal insulin (r=-.211, p=0.009) and homeostatic insulin resistance model (HOMA-IR) HOMA-IR (r=-.221, p=0.013). Resistin was correlated negatively with PFS (r=-.203, p=0.023), while its correlation with OD, BMI, WHR, and HOMA-IR was not significant. AR ratio was positively correlated with PFS (r=.286, p=0.001) and negatively with OD (r=-.210, p=0.019), BMI (r=-.222, p=0.013), WHR (r=-.308, p=0.001) and basal insulin (r=-.237, p=0.008). 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引用次数: 0

摘要

背景本研究旨在评估健康成年男性的体能评分（PFS）与血清脂肪连通素、抵抗素和脂肪连通素/抵抗素比值（AR 比值）的相关性。材料与方法这项横断面研究于 2017 年 3 月至 2018 年 4 月在利雅得沙特国王大学医学城沙特国王大学生理学系临床生理学组进行。我们纳入了 125 名健康成年男性。在一夜禁食后采集血清样本。对空腹血糖 (FBG)、糖化血红蛋白 (HbA1c)、基础胰岛素、血脂概况、抵抗素和脂肪连通素进行了分析。生物阻抗分析（BIA）用于评估身体成分。根据理想的身体成分，计算出所有受试者的 PFS，并与血清指标进行比较。结果脂肪连素与 PFS 呈正相关（r=.218，p=0.015），与肥胖程度（OD）、OD（r=-.239，p=0.001）、体重指数（BMI）（r=-.244，p=0.001）和腰围/臀围比（WHR）WHR（r=-.296，p=0.001）呈反向相关。此外，它与基础胰岛素（r=-.211，p=0.009）和胰岛素抵抗平衡模型（HOMA-IR）HOMA-IR（r=-.221，p=0.013）呈负相关。Resistin 与 PFS 呈负相关（r=-.203，p=0.023），而与 OD、BMI、WHR 和 HOMA-IR 的相关性不显著。AR比值与PFS呈正相关（r=.286，p=0.001），与OD（r=-.210，p=0.019）、BMI（r=-.222，p=0.013）、WHR（r=-.308，p=0.001）和基础胰岛素（r=-.237，p=0.008）呈负相关。在线性回归分析中，PFS 与脂肪连接素（r=.218，p=0.015）、抵抗素（r=-.203，p=0.023）和 AR 比率（r=.286，p=0.001）的关系显著。ROC曲线分析表明，单独的脂肪连接蛋白和抵抗素值与PFS无显著相关性，但它们与AR比值有显著相关性，AUC为64.6%（P=0.029）。结论血清脂肪连接蛋白与体能评分呈正相关，而抵抗素与体能评分呈负相关。然而，脂肪连通素/抵抗素比率的综合效应能更好地预测体能。此外，与单独使用脂肪连通素或抵抗素相比，脂肪连通素/抵抗素比率与体能的相关性更高。

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Circulating Adiponectin and Resistin Levels Are Associated with Adiposity Indices and Physical Fitness in Healthy Adult Males.

BACKGROUND The aim of this study was to assess the correlation of physical fitness scores (PFS) with serum adiponectin, resistin, and adiponectin/resistin ratio (AR ratio) in relation to body adiposity indices in healthy adult males. MATERIAL AND METHODS This cross-sectional study was conducted at the Clinical Physiology Unit, Physiology Department, King Saud University Medical City, King Saud University, Riyadh, from March 2017 to April 2018. We included 125 healthy adult males. Serum samples were obtained after overnight fasting. Analysis was performed for fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), basal insulin, lipid profile, resistin, and adiponectin. Bioimpedance analysis (BIA) was used to assess body composition. Based on ideal body composition, PFS were computed as previously published for all subjects and compared with serum markers. RESULTS There was a positive correlation of adiponectin with PFS (r=.218, p=0.015) and an inverse correlation with obesity degree (OD), OD (r=-.239, p=0.001), body mass index (BMI) (r=-.244, p=0.001), and waist/hip ratio (WHR) WHR (r=-.296, p=0.001). Moreover, it was correlated negatively with basal insulin (r=-.211, p=0.009) and homeostatic insulin resistance model (HOMA-IR) HOMA-IR (r=-.221, p=0.013). Resistin was correlated negatively with PFS (r=-.203, p=0.023), while its correlation with OD, BMI, WHR, and HOMA-IR was not significant. AR ratio was positively correlated with PFS (r=.286, p=0.001) and negatively with OD (r=-.210, p=0.019), BMI (r=-.222, p=0.013), WHR (r=-.308, p=0.001) and basal insulin (r=-.237, p=0.008). In linear regression analysis, the relationship of PFS was significant with adiponectin (r=.218, p=0.015), resistin (r=-.203, p=0.023) and AR ratio (r=.286, p=0.001). ROC curve analysis showed that individually the values of adiponectin and resistin were not significantly correlated with PFS, but they were significant with the combined AR ratio with AUC 64.6% (p=0.029). CONCLUSIONS Serum adiponectin was positively correlated and resistin was negatively correlated with physical fitness scores based on healthy body composition with low proportion of body adiposity and a higher proportion of fat-free mass. However, the combined effect of adiponectin/resistin ratio is an even better predictor of physical fitness. Moreover, the adiponectin/resistin ratio is even more highly associated with physical fitness than adiponectin or resistin alone.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.