{"title":"母亲铅暴露与早产风险的关系:一项荟萃分析。","authors":"Ahmad Habibian, Morteza Abyadeh, Mostafa Abyareh, Nader Rahimi Kakavandi, Atefeh Habibian, Maliheh Khakpash, Mahmoud Ghazi-Khansari","doi":"10.1080/14767058.2021.1946780","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The relationship between maternal lead level and risk of preterm birth (PTB) remained controversial. Therefore, herein we performed this meta-analysis to investigate the association of maternal blood, urine and cord blood lead level with the risk of PTB using observational studies.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, EMBASE and Ovid Medline databases from inception to August 2019, and sixteen studies with 65600 participants investigating the association between maternal lead level and PTB were included in our meta-analysis. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for the highest versus lowest lead level by random-effects model.</p><p><strong>Results: </strong>Overall, the pooled OR of all included articles for the highest versus lowest PTB score was 1.29 (95% CI = 1.14-1.46; I2 = 80.4%, <i>p</i> < .001), and the results revealed a direct and significant relationship between second and third trimester blood lead level (BLL) and PTB (OR 2nd trimester= 1.61, 95% CI = 1.08-2.40, OR 3rd trimester= 1.57, 95% CI = 1.11-2.23).</p><p><strong>Conclusion: </strong>Results of this meta-analysis showed that maternal BLL is directly associated with the risk of PTB.</p>","PeriodicalId":520807,"journal":{"name":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","volume":" ","pages":"7222-7230"},"PeriodicalIF":0.0000,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/14767058.2021.1946780","citationCount":"6","resultStr":"{\"title\":\"Association of maternal lead exposure with the risk of preterm: a meta-analysis.\",\"authors\":\"Ahmad Habibian, Morteza Abyadeh, Mostafa Abyareh, Nader Rahimi Kakavandi, Atefeh Habibian, Maliheh Khakpash, Mahmoud Ghazi-Khansari\",\"doi\":\"10.1080/14767058.2021.1946780\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The relationship between maternal lead level and risk of preterm birth (PTB) remained controversial. Therefore, herein we performed this meta-analysis to investigate the association of maternal blood, urine and cord blood lead level with the risk of PTB using observational studies.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, EMBASE and Ovid Medline databases from inception to August 2019, and sixteen studies with 65600 participants investigating the association between maternal lead level and PTB were included in our meta-analysis. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for the highest versus lowest lead level by random-effects model.</p><p><strong>Results: </strong>Overall, the pooled OR of all included articles for the highest versus lowest PTB score was 1.29 (95% CI = 1.14-1.46; I2 = 80.4%, <i>p</i> < .001), and the results revealed a direct and significant relationship between second and third trimester blood lead level (BLL) and PTB (OR 2nd trimester= 1.61, 95% CI = 1.08-2.40, OR 3rd trimester= 1.57, 95% CI = 1.11-2.23).</p><p><strong>Conclusion: </strong>Results of this meta-analysis showed that maternal BLL is directly associated with the risk of PTB.</p>\",\"PeriodicalId\":520807,\"journal\":{\"name\":\"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians\",\"volume\":\" \",\"pages\":\"7222-7230\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/14767058.2021.1946780\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/14767058.2021.1946780\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/7/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/14767058.2021.1946780","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/7/1 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
摘要
背景:产妇铅水平与早产(PTB)风险之间的关系仍存在争议。因此，我们在此进行了这项荟萃分析，通过观察性研究来调查母体血、尿和脐带血铅水平与PTB风险的关系。方法:系统检索PubMed、EMBASE和Ovid Medline数据库，从成立到2019年8月，将16项涉及65600名参与者的研究纳入我们的荟萃分析，这些研究调查了孕产妇铅水平与PTB之间的关系。通过随机效应模型计算最高和最低铅水平的优势比(ORs)和95%置信区间(95% CI)。结果:总体而言，所有纳入的文献中PTB评分最高与最低的合并OR为1.29 (95% CI = 1.14-1.46;结论:本荟萃分析结果显示，产妇BLL与PTB的风险直接相关。
Association of maternal lead exposure with the risk of preterm: a meta-analysis.
Background: The relationship between maternal lead level and risk of preterm birth (PTB) remained controversial. Therefore, herein we performed this meta-analysis to investigate the association of maternal blood, urine and cord blood lead level with the risk of PTB using observational studies.
Methods: A systematic search was conducted in PubMed, EMBASE and Ovid Medline databases from inception to August 2019, and sixteen studies with 65600 participants investigating the association between maternal lead level and PTB were included in our meta-analysis. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for the highest versus lowest lead level by random-effects model.
Results: Overall, the pooled OR of all included articles for the highest versus lowest PTB score was 1.29 (95% CI = 1.14-1.46; I2 = 80.4%, p < .001), and the results revealed a direct and significant relationship between second and third trimester blood lead level (BLL) and PTB (OR 2nd trimester= 1.61, 95% CI = 1.08-2.40, OR 3rd trimester= 1.57, 95% CI = 1.11-2.23).
Conclusion: Results of this meta-analysis showed that maternal BLL is directly associated with the risk of PTB.
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