Thubeena Manickavasagar, Wei Yuan, Suzanne Carreira, Bora Gurel, Susana Miranda, Ana Ferreira, Mateus Crespo, Ruth Riisnaes, Chloe Baker, Mary O'Brien, Jaishree Bhosle, Sanjay Popat, Udai Banerji, Juanita Lopez, Johann de Bono, Anna Minchom
{"title":"HER3在非小细胞肺癌中的表达和MEK的激活。","authors":"Thubeena Manickavasagar, Wei Yuan, Suzanne Carreira, Bora Gurel, Susana Miranda, Ana Ferreira, Mateus Crespo, Ruth Riisnaes, Chloe Baker, Mary O'Brien, Jaishree Bhosle, Sanjay Popat, Udai Banerji, Juanita Lopez, Johann de Bono, Anna Minchom","doi":"10.2217/lmt-2020-0031","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>We explore HER3 expression in lung adenocarcinoma (adeno-NSCLC) and identify potential mechanisms of HER3 expression.</p><p><strong>Materials & methods: </strong>Tumor samples from 45 patients with adeno-NSCLC were analyzed. HER3 and HER2 expression were identified using immunohistochemistry and bioinformatic interrogation of The Cancer Genome Atlas (TCGA).</p><p><strong>Results: </strong>HER3 was highly expressed in 42.2% of cases. <i>ERBB3</i> copy number did not account for HER3 overexpression. Bioinformatic analysis of TCGA demonstrated that MEK activity score (a surrogate of functional signaling) did not correlate with HER3 ligands. <i>ERBB3</i> RNA expression levels were significantly correlated with MEK activity after adjusting for <i>EGFR</i> expression.</p><p><strong>Conclusion: </strong>HER3 expression is common and is a potential therapeutic target by virtue of frequent overexpression and functional downstream signaling.</p>","PeriodicalId":0,"journal":{"name":"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9b/37/lmt-10-48.PMC8162178.pdf","citationCount":"4","resultStr":"{\"title\":\"HER3 expression and MEK activation in non-small-cell lung carcinoma.\",\"authors\":\"Thubeena Manickavasagar, Wei Yuan, Suzanne Carreira, Bora Gurel, Susana Miranda, Ana Ferreira, Mateus Crespo, Ruth Riisnaes, Chloe Baker, Mary O'Brien, Jaishree Bhosle, Sanjay Popat, Udai Banerji, Juanita Lopez, Johann de Bono, Anna Minchom\",\"doi\":\"10.2217/lmt-2020-0031\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>We explore HER3 expression in lung adenocarcinoma (adeno-NSCLC) and identify potential mechanisms of HER3 expression.</p><p><strong>Materials & methods: </strong>Tumor samples from 45 patients with adeno-NSCLC were analyzed. HER3 and HER2 expression were identified using immunohistochemistry and bioinformatic interrogation of The Cancer Genome Atlas (TCGA).</p><p><strong>Results: </strong>HER3 was highly expressed in 42.2% of cases. <i>ERBB3</i> copy number did not account for HER3 overexpression. Bioinformatic analysis of TCGA demonstrated that MEK activity score (a surrogate of functional signaling) did not correlate with HER3 ligands. <i>ERBB3</i> RNA expression levels were significantly correlated with MEK activity after adjusting for <i>EGFR</i> expression.</p><p><strong>Conclusion: </strong>HER3 expression is common and is a potential therapeutic target by virtue of frequent overexpression and functional downstream signaling.</p>\",\"PeriodicalId\":0,\"journal\":{\"name\":\"\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0,\"publicationDate\":\"2021-04-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9b/37/lmt-10-48.PMC8162178.pdf\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2217/lmt-2020-0031\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/lmt-2020-0031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
HER3 expression and MEK activation in non-small-cell lung carcinoma.
Aim: We explore HER3 expression in lung adenocarcinoma (adeno-NSCLC) and identify potential mechanisms of HER3 expression.
Materials & methods: Tumor samples from 45 patients with adeno-NSCLC were analyzed. HER3 and HER2 expression were identified using immunohistochemistry and bioinformatic interrogation of The Cancer Genome Atlas (TCGA).
Results: HER3 was highly expressed in 42.2% of cases. ERBB3 copy number did not account for HER3 overexpression. Bioinformatic analysis of TCGA demonstrated that MEK activity score (a surrogate of functional signaling) did not correlate with HER3 ligands. ERBB3 RNA expression levels were significantly correlated with MEK activity after adjusting for EGFR expression.
Conclusion: HER3 expression is common and is a potential therapeutic target by virtue of frequent overexpression and functional downstream signaling.
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