早产儿的氧化应激生物标志物。

2区医学 Q1 Chemistry

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-12-17 DOI:10.1016/bs.acc.2020.08.011

Ángel Sánchez-Illana, José David Piñeiro-Ramos, Victoria Ramos-Garcia, Isabel Ten-Doménech, Máximo Vento, Julia Kuligowski

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引用次数: 5

摘要

氧化应激(OS)在早产儿的病理生理中起着关键作用。对操作系统的准确评估仍然是一项分析挑战，在过去几十年中已经得到了部分解决。已经开发了大量的方法来评估早产生物流体，以证明出生后与早产OS的联系，从而产生了一套广泛使用的生物标志物。然而，大量不同的分析方法和缺乏标准化阻碍了os相关生物标志物的可靠比较。在本章中，我们从方法学的考虑、不同生物标志物的代谢来源及其在临床研究中的作用等方面讨论了早产儿OS研究的方法。

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Oxidative stress biomarkers in the preterm infant.

Oxidative stress (OS) plays a key role in the pathophysiology of preterm infants. Accurate assessment of OS remains an analytical challenge that has been partially addressed during the last few decades. A plethora of approaches have been developed to assess preterm biofluids to demonstrate a link postnatally with preterm OS, giving rise to a set of widely employed biomarkers. However, the vast number of different analytic methods and lack of standardization hampers reliable comparison of OS-related biomarkers. In this chapter, we discuss approaches for the study of OS in prematurity with respect to methodologic considerations, the metabolic source of different biomarkers and their role in clinical studies.

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来源期刊

Advances in Clinical Chemistry 医学-医学实验技术

CiteScore

10.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Clinical Chemistry volumes contain material by leading experts in academia and clinical laboratory science. The reviews cover a wide variety of clinical chemistry disciplines including clinical biomarker exploration, cutting edge microarray technology, proteomics and genomics. It is an indispensable resource and practical guide for practitioners of clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences in general.