人类间歇性禁食期间有益肠道微生物群的重塑

IF 2.2 4区 医学 Q3 GERIATRICS & GERONTOLOGY
Jasmine W Larrick, Andrew R Mendelsohn, James W Larrick
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引用次数: 5

摘要

间歇性禁食(IF)是在一个较长的禁食周期内限制食物摄入12-48小时的做法。先前的研究显示了有益的健康效果,如减肥和降低患心脏代谢疾病的风险。虽然减少卡路里的摄入可以解释一些观察到的IF的好处,但确切的机制仍然不清楚。最近的证据表明,IF可能导致人类肠道微生物群的重塑和分类多样性的增加。特别是,在禁食期间,厌氧细菌的毛螺科家族增加。这个家族属于梭菌目,促进肠道内的butygenesis,这一过程与健康的代谢和延年益寿的作用有关。干扰素相关的微生物组改变可能在干扰素和饮食限制的代谢和潜在的健康增强益处中发挥关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Beneficial Gut Microbiome Remodeled During Intermittent Fasting in Humans.

Intermittent fasting (IF) is the practice of restricting food intake for 12-48 hours per fasting cycle over a prolonged period of time. Previous study shows beneficial health effects such as weight loss and lower risk for cardiometabolic diseases. Although reduced calorie intake may account for some of the observed benefits of IF, exact mechanisms are still unclear. Recent evidence indicates that IF may lead to remodeling and increased taxonomic diversity in the human gut microbiome. In particular, the Lachnospiraceae family of anaerobic bacteria increased during fasting. This family, in the order Clostridiales, promotes butryogenesis in the gut, a process that is associated with healthful metabolic and prolongevity effects. IF-associated alterations to the microbiome may play a key role in the metabolic and potential healthspan-enhancing benefits of IF and dietary restriction.

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来源期刊
Rejuvenation research
Rejuvenation research 医学-老年医学
CiteScore
4.50
自引率
0.00%
发文量
41
审稿时长
3 months
期刊介绍: Rejuvenation Research publishes cutting-edge, peer-reviewed research on rejuvenation therapies in the laboratory and the clinic. The Journal focuses on key explorations and advances that may ultimately contribute to slowing or reversing the aging process, and covers topics such as cardiovascular aging, DNA damage and repair, cloning, and cell immortalization and senescence. Rejuvenation Research coverage includes: Cell immortalization and senescence Pluripotent stem cells DNA damage/repair Gene targeting, gene therapy, and genomics Growth factors and nutrient supply/sensing Immunosenescence Comparative biology of aging Tissue engineering Late-life pathologies (cardiovascular, neurodegenerative and others) Public policy and social context.
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