kratom诱导的转氨炎,随后在纳曲酮后沉淀阿片类药物戒断。

The Mental Health Clinician Pub Date : 2021-05-12 eCollection Date: 2021-05-01 DOI:10.9740/mhc.2021.05.220
Aimee N Jensen, Quynh-Nhu Truong, Melanie Jameson, Celeste N Nadal
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引用次数: 5

摘要

Kratom是一种草药补充剂,在美国已经获得了流行的娱乐用途。Kratom具有类似阿片类药物的作用,尽管未经美国FDA批准,但通常用于自我治疗疼痛,阿片类药物戒断管理和欣快感。药物相关性肝损伤与克拉通的使用有关。所有这些都引起了对患者安全和监测的关注。当克拉通与肝毒性药物、非处方药、中草药和处方药同时使用时,必须考虑潜在的肝毒性。本病例报告描述了一例克拉通诱导的肝脏炎症并发阿片类药物戒断,这是由IM纳曲酮开始沉淀。据我们所知,在使用kratom(无其他阿片类药物)的患者中,没有发表过与纳曲酮给药后阿片类药物戒断相关的病例报告。本病例报告的目的是展示使用克瑞通可能出现的潜在并发症,以及在克瑞通使用者开始使用纳曲酮之前应考虑的事项。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Kratom-induced transaminitis with subsequent precipitated opioid withdrawal following naltrexone.

Kratom is an herbal supplement that has gained popularity for recreational use within the United States. Kratom exerts opioid-like effects and, although not US FDA approved, is commonly used for self-treatment of pain, withdrawal management from opioids, and euphoria. Drug-related hepatic injury has been associated with kratom use. All of this raises concern for patient safety and monitoring. The potential for additive liver toxicity must be considered when kratom is used concurrently with hepatotoxic, over-the-counter, herbal, and prescription medications. This case report describes a case of kratom-induced liver inflammation complicated by opioid withdrawal that was precipitated by initiation of IM naltrexone. To our knowledge, there are no published case reports related to opioid withdrawal following naltrexone administration in patients using kratom (without other opioids). The purpose of this case report is to demonstrate potential complications that may arise with kratom use and considerations that should be taken prior to initiation of naltrexone in kratom users.

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