BRCA2和DDX5之间的新相互作用促进了转录染色质上DNA断裂的修复。

IF 2.6 Q3 ONCOLOGY

Molecular and Cellular Oncology Pub Date : 2021-04-14 eCollection Date: 2021-01-01 DOI:10.1080/23723556.2021.1910474

Belen Gómez-González, Gaetana Sessa, Aura Carreira, Andrés Aguilera

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引用次数: 4

摘要

在最近的一篇报道中，我们揭示了BRCA2 DNA修复相关蛋白(BRCA2)和DNA断裂处的DEAD-box解旋酶5 (DDX5)之间的一种新的相互作用，这种相互作用促进了转录染色质内DNA- rna杂交的解绕，并有利于修复。有趣的是，在乳腺癌患者中发现的表达BRCA2T2 07A错义变体的细胞中，BRCA2-DDX5相互作用受损。

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A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin.

In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2-DDX5 interaction is impaired in cells expressing the BRCA2^T2 ^07A missense variant found in breast cancer patients.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.