{"title":"肢端肥大症患者的泪腺增大和泪膜改变:一项对照研究","authors":"Burak Mergen , Ceyhun Arici , Osman Kizilkilic , Necmettin Tanriover , Pinar Kadioglu","doi":"10.1016/j.ghir.2021.101397","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>Evaluation of the lacrimal gland<span> volume (LGV) and its correlation with tear film functions, serum growth hormone<span> (GH) and insulin-like growth factor-1 (IGF-1) levels in acromegaly patients compared to a control group was aimed.</span></span></p></div><div><h3>Methods</h3><p>This prospective case-control study included the eyes of 38 patients with uncontrolled (UA) and 48 patients with controlled acromegaly (CA) and 44 patients with nonfunctioning pituitary adenoma<span>. LGV of the patients was evaluated at the baseline, 3rd, and 6th-month visits with magnetic resonance imaging. Schirmer's test, tear breakup time (TBUT), and ocular surface disease index (OSDI) scores were evaluated at the same visits. Their correlation with serum IGF-1 and GH was investigated. Main outcome measure was the difference in mean LGV.</span></p></div><div><h3>Results</h3><p>The mean LGV of the acromegaly patients at the baseline visit (116.0 ± 33.2 mm<sup>3</sup>) and the 3rd-month visit (119.5 ± 36.4 mm<sup>3</sup>) was higher than the control group (65.2 ± 22.3 mm<sup>3</sup> and 63.2 ± 22.3 mm<sup>3</sup>, respectively; <em>p</em> < 0.001) without any significant difference between the UA and CA patients in the LGV in three consecutive visits (<em>p</em> > 0.05). Among all patients, IGF-1 and GH levels showed a positive correlation with the LGV (<em>p</em> < 0.001; r = 0.52; r = 0.6, respectively). However, Schirmer, TBUT, and OSDI scores did not show any difference among the three groups at each visit (<em>p</em> > 0.05).</p></div><div><h3>Conclusion</h3><p>Acromegaly patients may have larger lacrimal glands compared to the controls and this increase correlated with the increased IGF-1 and GH levels. Lacrimal gland volume may have no effect on its tear film related functions.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ghir.2021.101397","citationCount":"1","resultStr":"{\"title\":\"Lacrimal gland enlargement and tear film changes in acromegaly patients: A controlled study\",\"authors\":\"Burak Mergen , Ceyhun Arici , Osman Kizilkilic , Necmettin Tanriover , Pinar Kadioglu\",\"doi\":\"10.1016/j.ghir.2021.101397\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>Evaluation of the lacrimal gland<span> volume (LGV) and its correlation with tear film functions, serum growth hormone<span> (GH) and insulin-like growth factor-1 (IGF-1) levels in acromegaly patients compared to a control group was aimed.</span></span></p></div><div><h3>Methods</h3><p>This prospective case-control study included the eyes of 38 patients with uncontrolled (UA) and 48 patients with controlled acromegaly (CA) and 44 patients with nonfunctioning pituitary adenoma<span>. LGV of the patients was evaluated at the baseline, 3rd, and 6th-month visits with magnetic resonance imaging. Schirmer's test, tear breakup time (TBUT), and ocular surface disease index (OSDI) scores were evaluated at the same visits. Their correlation with serum IGF-1 and GH was investigated. Main outcome measure was the difference in mean LGV.</span></p></div><div><h3>Results</h3><p>The mean LGV of the acromegaly patients at the baseline visit (116.0 ± 33.2 mm<sup>3</sup>) and the 3rd-month visit (119.5 ± 36.4 mm<sup>3</sup>) was higher than the control group (65.2 ± 22.3 mm<sup>3</sup> and 63.2 ± 22.3 mm<sup>3</sup>, respectively; <em>p</em> < 0.001) without any significant difference between the UA and CA patients in the LGV in three consecutive visits (<em>p</em> > 0.05). Among all patients, IGF-1 and GH levels showed a positive correlation with the LGV (<em>p</em> < 0.001; r = 0.52; r = 0.6, respectively). However, Schirmer, TBUT, and OSDI scores did not show any difference among the three groups at each visit (<em>p</em> > 0.05).</p></div><div><h3>Conclusion</h3><p>Acromegaly patients may have larger lacrimal glands compared to the controls and this increase correlated with the increased IGF-1 and GH levels. Lacrimal gland volume may have no effect on its tear film related functions.</p></div>\",\"PeriodicalId\":12803,\"journal\":{\"name\":\"Growth Hormone & Igf Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2021-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ghir.2021.101397\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Growth Hormone & Igf Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1096637421000204\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Growth Hormone & Igf Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1096637421000204","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Lacrimal gland enlargement and tear film changes in acromegaly patients: A controlled study
Purpose
Evaluation of the lacrimal gland volume (LGV) and its correlation with tear film functions, serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels in acromegaly patients compared to a control group was aimed.
Methods
This prospective case-control study included the eyes of 38 patients with uncontrolled (UA) and 48 patients with controlled acromegaly (CA) and 44 patients with nonfunctioning pituitary adenoma. LGV of the patients was evaluated at the baseline, 3rd, and 6th-month visits with magnetic resonance imaging. Schirmer's test, tear breakup time (TBUT), and ocular surface disease index (OSDI) scores were evaluated at the same visits. Their correlation with serum IGF-1 and GH was investigated. Main outcome measure was the difference in mean LGV.
Results
The mean LGV of the acromegaly patients at the baseline visit (116.0 ± 33.2 mm3) and the 3rd-month visit (119.5 ± 36.4 mm3) was higher than the control group (65.2 ± 22.3 mm3 and 63.2 ± 22.3 mm3, respectively; p < 0.001) without any significant difference between the UA and CA patients in the LGV in three consecutive visits (p > 0.05). Among all patients, IGF-1 and GH levels showed a positive correlation with the LGV (p < 0.001; r = 0.52; r = 0.6, respectively). However, Schirmer, TBUT, and OSDI scores did not show any difference among the three groups at each visit (p > 0.05).
Conclusion
Acromegaly patients may have larger lacrimal glands compared to the controls and this increase correlated with the increased IGF-1 and GH levels. Lacrimal gland volume may have no effect on its tear film related functions.
期刊介绍：
Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
