{"title":"纳尔逊-曼德拉学术医院幽门螺杆菌感染率及相关恶性和消化性溃疡病 (PUD) 发病率：回顾性分析。","authors":"Stephen Z Molaoa","doi":"10.1080/21556660.2020.1854560","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong><i>H. pylori</i> infection is associated with both benign and malignant gastrointestinal diseases. However, no studies have been conducted locally describing the prevalence of <i>H. pylori</i> and its associated GIT diseases. The objectives of this study are to determine the prevalence of <i>H. pylori</i>, and the incidence of PUD and gastric malignancies among patients who are infected with <i>H. pylori</i> or who have the stigmata of previous exposure to <i>H. pylori</i>.</p><p><strong>Material and methods: </strong>Data was collected retrospectively from files of adult patients with upper gastro-intestinal symptoms from January to December, 2012. The gastric mucosal biopsy specimens were analyzed for the presence of <i>H. pylori</i>, chronic gastritis, PUD, and gastric malignancies.</p><p><strong>Results: </strong>Of 156 records there were 70 (45%) males and 86 (55%) females, with a median age of 56.5. The prevalence of <i>H. pylori</i> was 54.5%; 95% of 156 had chronic gastritis (CG). Ninety-sever percent of the 85 <i>H. pylori</i> positive and 93% of the 71 <i>H. pylori</i> negative patients had CG. However, the difference was not statistically significant (97% vs 93%, <i>p</i> = 0.322). The incidence of PUD was 16% and 10 (6.4%) had gastric malignancies, of which four (2.7%) and three (2%) were antral intestinal-type and proximal diffuse types, respectively. Three (2%) had gastric MALT lymphoma. The risk of both gastric malignancies and PUD was demonstrated to increase with advancing age.</p><p><strong>Discussion and conclusion: </strong>The prevalence of <i>H. pylori</i> was equivalent to the global prevalence; however, high prevalence of CG may be indicative of high local infection rate. The incidence of <i>H. pylori</i> and/or chronic gastritis-associated intestinal-type gastric adenocarcinoma, MALT lymphoma, and PUD is equivalent to that reported globally. Advancing age and active <i>H. pylori</i> infection or stigmata of past exposure thereto are associated with increased risk of peptic ulcers and malignant gastric diseases.</p>","PeriodicalId":15631,"journal":{"name":"Journal of Drug Assessment","volume":"10 1","pages":"57-61"},"PeriodicalIF":2.4000,"publicationDate":"2021-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/4d/IJDA_10_1854560.PMC8158191.pdf","citationCount":"0","resultStr":"{\"title\":\"Prevalence of <i>Helicobacter pylori</i> infection and the incidence of the associated malignant and peptic ulcer disease (PUD) at Nelson Mandela Academic Hospital: a retrospective analysis.\",\"authors\":\"Stephen Z Molaoa\",\"doi\":\"10.1080/21556660.2020.1854560\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong><i>H. pylori</i> infection is associated with both benign and malignant gastrointestinal diseases. However, no studies have been conducted locally describing the prevalence of <i>H. pylori</i> and its associated GIT diseases. The objectives of this study are to determine the prevalence of <i>H. pylori</i>, and the incidence of PUD and gastric malignancies among patients who are infected with <i>H. pylori</i> or who have the stigmata of previous exposure to <i>H. pylori</i>.</p><p><strong>Material and methods: </strong>Data was collected retrospectively from files of adult patients with upper gastro-intestinal symptoms from January to December, 2012. The gastric mucosal biopsy specimens were analyzed for the presence of <i>H. pylori</i>, chronic gastritis, PUD, and gastric malignancies.</p><p><strong>Results: </strong>Of 156 records there were 70 (45%) males and 86 (55%) females, with a median age of 56.5. The prevalence of <i>H. pylori</i> was 54.5%; 95% of 156 had chronic gastritis (CG). Ninety-sever percent of the 85 <i>H. pylori</i> positive and 93% of the 71 <i>H. pylori</i> negative patients had CG. However, the difference was not statistically significant (97% vs 93%, <i>p</i> = 0.322). The incidence of PUD was 16% and 10 (6.4%) had gastric malignancies, of which four (2.7%) and three (2%) were antral intestinal-type and proximal diffuse types, respectively. Three (2%) had gastric MALT lymphoma. The risk of both gastric malignancies and PUD was demonstrated to increase with advancing age.</p><p><strong>Discussion and conclusion: </strong>The prevalence of <i>H. pylori</i> was equivalent to the global prevalence; however, high prevalence of CG may be indicative of high local infection rate. The incidence of <i>H. pylori</i> and/or chronic gastritis-associated intestinal-type gastric adenocarcinoma, MALT lymphoma, and PUD is equivalent to that reported globally. Advancing age and active <i>H. pylori</i> infection or stigmata of past exposure thereto are associated with increased risk of peptic ulcers and malignant gastric diseases.</p>\",\"PeriodicalId\":15631,\"journal\":{\"name\":\"Journal of Drug Assessment\",\"volume\":\"10 1\",\"pages\":\"57-61\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2021-02-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/4d/IJDA_10_1854560.PMC8158191.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Drug Assessment\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/21556660.2020.1854560\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drug Assessment","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21556660.2020.1854560","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Prevalence of Helicobacter pylori infection and the incidence of the associated malignant and peptic ulcer disease (PUD) at Nelson Mandela Academic Hospital: a retrospective analysis.
Background: H. pylori infection is associated with both benign and malignant gastrointestinal diseases. However, no studies have been conducted locally describing the prevalence of H. pylori and its associated GIT diseases. The objectives of this study are to determine the prevalence of H. pylori, and the incidence of PUD and gastric malignancies among patients who are infected with H. pylori or who have the stigmata of previous exposure to H. pylori.
Material and methods: Data was collected retrospectively from files of adult patients with upper gastro-intestinal symptoms from January to December, 2012. The gastric mucosal biopsy specimens were analyzed for the presence of H. pylori, chronic gastritis, PUD, and gastric malignancies.
Results: Of 156 records there were 70 (45%) males and 86 (55%) females, with a median age of 56.5. The prevalence of H. pylori was 54.5%; 95% of 156 had chronic gastritis (CG). Ninety-sever percent of the 85 H. pylori positive and 93% of the 71 H. pylori negative patients had CG. However, the difference was not statistically significant (97% vs 93%, p = 0.322). The incidence of PUD was 16% and 10 (6.4%) had gastric malignancies, of which four (2.7%) and three (2%) were antral intestinal-type and proximal diffuse types, respectively. Three (2%) had gastric MALT lymphoma. The risk of both gastric malignancies and PUD was demonstrated to increase with advancing age.
Discussion and conclusion: The prevalence of H. pylori was equivalent to the global prevalence; however, high prevalence of CG may be indicative of high local infection rate. The incidence of H. pylori and/or chronic gastritis-associated intestinal-type gastric adenocarcinoma, MALT lymphoma, and PUD is equivalent to that reported globally. Advancing age and active H. pylori infection or stigmata of past exposure thereto are associated with increased risk of peptic ulcers and malignant gastric diseases.
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