老年灰鼠狐猴的纤维性骨营养不良、慢性肾脏疾病和子宫腺癌。

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Comparative medicine Pub Date : 2021-06-01 Epub Date: 2021-06-03 DOI:10.30802/AALAS-CM-20-000078
Kerriann M Casey, Caitlin J Karanewsky, Jozeph L Pendleton, Mark R Krasnow, Megan A Albertelli
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引用次数: 2

摘要

灰鼠狐猴(Microcebus murinus, GML)是一种原产于马达加斯加的夜行、树栖、原猿灵长类动物。人工圈养的转基因生物繁殖菌落主要用于对昼夜节律和代谢相关问题的非侵入性研究。由于与老年人类有重叠的组织病理特征,gml越来越被认为是神经认知衰老的一个强有力的翻译模型。然而,关于老年gml的临床表现、自然发生的疾病和组织病理学的信息很少。在我们的群体中,一名9岁的男性GML在突然出现虚弱,嗜睡和胫骨骨折后被安乐死。这只动物的评估显示广泛的纤维性骨营养不良(FOD)在下颌骨,上颌骨,头盖骨,尾骨和椎骨。FOD和全身转移性矿化归因于潜在的慢性肾脏疾病。这种GML的发现促使定期进行全菌落血清生化筛查,以检查氮血症和电解质异常。随后,另外3名gml(2名女性和1名男性)因不同的临床和血清生化表现而被安乐死。所有4只动物的共同点是FOD、慢性肾病、子宫腺癌(仅限雌性)、白内障和骨关节炎。本案例研究强调了与在不断扩大的衰老研究领域中使用gml相关的并发临床和组织病理学异常。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fibrous Osteodystrophy, Chronic Renal Disease, and Uterine Adenocarcinoma in Aged Gray Mouse Lemurs (Microcebus murinus).

The gray mouse lemur (Microcebus murinus, GML) is a nocturnal, arboreal, prosimian primate that is native to Madagascar. Captive breeding colonies of GMLs have been established primarily for noninvasive studies on questions related to circadian rhythms and metabolism. GMLs are increasingly considered to be a strong translational model for neurocognitive aging due to overlapping histopathologic features shared with aged humans. However, little information is available describing the clinical presentations, naturally occurring diseases, and histopathology of aged GMLs. In our colony, a 9 y-old, male, GML was euthanized after sudden onset of weakness, lethargy, and tibial fracture. Evaluation of this animal revealed widespread fibrous osteodystrophy (FOD) of the mandible, maxilla, cranium, appendicular, and vertebral bones. FOD and systemic metastatic mineralization were attributed to underlying chronic renal disease. Findings in this GML prompted periodic colony-wide serum biochemical screenings for azotemia and electrolyte abnormalities. Subsequently, 3 additional GMLs (2 females and 1 male) were euthanized due to varying clinical and serum biochemical presentations. Common to all 4 animals were FOD, chronic renal disease, uterine adenocarcinoma (females only), cataracts, and osteoarthritis. This case study highlights the concurrent clinical and histopathologic abnormalities that are relevant to use of GMLs in the expanding field of aging research.

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来源期刊
Comparative medicine
Comparative medicine 医学-动物学
CiteScore
1.90
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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