ppar - α激动剂非诺贝特联合醋酸奥曲肽治疗急性高脂血症胰腺炎。

IF 3.5 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
PPAR Research Pub Date : 2021-04-20 eCollection Date: 2021-01-01 DOI:10.1155/2021/6629455
Wen Bao, Rui Kong, Nan Wang, Wei Han, Jie Lu
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引用次数: 4

摘要

目前临床上急性高甘油三酯血症性胰腺炎患者越来越多。常见的治疗措施包括禁食和饮水,液体复苏和生长抑素。近年来,研究指出,PPARa激动剂非诺贝特可能有助于改善这类患者的病情。因此,通过临床研究和分析,我们首次报道了非诺贝特联合醋酸奥曲肽治疗急性高甘油三酯血症性胰腺炎的疗效更为优异,并从信号通路的角度揭示了两药联用对NF-κB P65的影响。协同抑制作用证明联合治疗有利于控制炎症,保护肝功能,改善患者预后。值得临床推广。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

PPAR-Alpha Agonist Fenofibrate Combined with Octreotide Acetate in the Treatment of Acute Hyperlipidemia Pancreatitis.

PPAR-Alpha Agonist Fenofibrate Combined with Octreotide Acetate in the Treatment of Acute Hyperlipidemia Pancreatitis.

PPAR-Alpha Agonist Fenofibrate Combined with Octreotide Acetate in the Treatment of Acute Hyperlipidemia Pancreatitis.

PPAR-Alpha Agonist Fenofibrate Combined with Octreotide Acetate in the Treatment of Acute Hyperlipidemia Pancreatitis.

At present, there are more and more patients with acute hypertriglyceridemia pancreatitis in clinical practice. Common treatment measures include fasting and water withdrawal, fluid resuscitation, and somatostatin. In recent years, studies have pointed out that the PPARa agonist fenofibrate may help improve the condition of such patients. Therefore, through clinical research and analysis, we reported for the first time that fenofibrate combined with octreotide acetate has a more excellent effect in the treatment of patients with acute hypertriglyceridemia pancreatitis, and from the perspective of signal pathways, we revealed that the combination of the two drugs has an effect on NF-κB P65. The synergistic inhibitory effect proves that the combined treatment is beneficial to control inflammation, protect liver function, and improve the prognosis of patients. It is worthy of clinical promotion.

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来源期刊
PPAR Research
PPAR Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.20
自引率
3.40%
发文量
17
审稿时长
12 months
期刊介绍: PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic research focusing on mechanisms involved in the activation of peroxisome proliferator-activated receptors (PPARs), as well as their role in the regulation of cellular differentiation, development, energy homeostasis and metabolic function. The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating chronic diseases and disorders such as dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, and obesity.
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