Andrea T Duran, Carol Ewing Garber, Ipek Ensari, Daichi Shimbo, Keith M Diaz
{"title":"习惯性久坐行为与内皮细胞健康之间的关系","authors":"Andrea T Duran, Carol Ewing Garber, Ipek Ensari, Daichi Shimbo, Keith M Diaz","doi":"10.1249/tjx.0000000000000138","DOIUrl":null,"url":null,"abstract":"<p><p>Endothelial dysfunction is a mechanism that may explain the link between prolonged sedentary time and cardiovascular disease. However, the relation between habitual sedentary behavior (SED) and endothelial function has yet to be explored.</p><p><strong>Purpose-: </strong>The purpose of this study was to examine the association of accelerometer-measured SED with markers of endothelial cell health.</p><p><strong>Methods-: </strong>Healthy adult participants (n=83; 43.4% male; 25.5 ± 5.8 years old) were examined. SED was measured for 7-days by accelerometer. Endothelial function measures included endothelium-dependent vasodilation (EDV); endothelial microparticles (EMPs) [CD62E+ and CD31+/CD42- EMPs]; and endothelial progenitor cells (EPCs) [CD34+/CD133+/KDR+ and CD34+/KDR+EPCs]. Participants were classified as having low or high SED based on a median split.</p><p><strong>Results-: </strong>Participants in the low and high SED group spent a mean ± SD of 8.6 ± 1.1 and 11.1 ± 1.0 h/day in SED, respectively. No significant differences between the low and high SED groups were detected in mean [95% confidence interval (CI)] EDV (2.51 [2.21-2.81] vs. 2.36 [2.07-2.64], <i>p</i>=0.50), EMPs (CD62E+: 6.70 [6.55-6.84] vs. 6.56 [6.42-6.69], <i>p</i>=0.20; CD31+/CD42‒: 6.26 [6.10-6.42] vs. 6.18 [6.03-6.33], <i>p</i>=0.50), or EPCs (CD34+/KDR+: 11.91 [9.23-14.48]×10<sup>-2</sup> vs. 14.87 [12.41-17.32]×10<sup>-2</sup>, <i>p</i>=0.13); CD34+/CD133+/KDR+: 1.84 [1.28-2.39]×10<sup>-2</sup> vs. 2.17 [1.64-2.70]×10<sup>-2</sup>, <i>p</i>=0.43).</p><p><strong>Conclusions-: </strong>Among healthy adults, habitual SED was not associated with markers of endothelial cell health.</p>","PeriodicalId":75243,"journal":{"name":"Translational journal of the American College of Sports Medicine","volume":"5 12","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087243/pdf/nihms-1672155.pdf","citationCount":"0","resultStr":"{\"title\":\"Associations Between Habitual Sedentary Behavior and Endothelial Cell Health.\",\"authors\":\"Andrea T Duran, Carol Ewing Garber, Ipek Ensari, Daichi Shimbo, Keith M Diaz\",\"doi\":\"10.1249/tjx.0000000000000138\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Endothelial dysfunction is a mechanism that may explain the link between prolonged sedentary time and cardiovascular disease. However, the relation between habitual sedentary behavior (SED) and endothelial function has yet to be explored.</p><p><strong>Purpose-: </strong>The purpose of this study was to examine the association of accelerometer-measured SED with markers of endothelial cell health.</p><p><strong>Methods-: </strong>Healthy adult participants (n=83; 43.4% male; 25.5 ± 5.8 years old) were examined. SED was measured for 7-days by accelerometer. Endothelial function measures included endothelium-dependent vasodilation (EDV); endothelial microparticles (EMPs) [CD62E+ and CD31+/CD42- EMPs]; and endothelial progenitor cells (EPCs) [CD34+/CD133+/KDR+ and CD34+/KDR+EPCs]. Participants were classified as having low or high SED based on a median split.</p><p><strong>Results-: </strong>Participants in the low and high SED group spent a mean ± SD of 8.6 ± 1.1 and 11.1 ± 1.0 h/day in SED, respectively. No significant differences between the low and high SED groups were detected in mean [95% confidence interval (CI)] EDV (2.51 [2.21-2.81] vs. 2.36 [2.07-2.64], <i>p</i>=0.50), EMPs (CD62E+: 6.70 [6.55-6.84] vs. 6.56 [6.42-6.69], <i>p</i>=0.20; CD31+/CD42‒: 6.26 [6.10-6.42] vs. 6.18 [6.03-6.33], <i>p</i>=0.50), or EPCs (CD34+/KDR+: 11.91 [9.23-14.48]×10<sup>-2</sup> vs. 14.87 [12.41-17.32]×10<sup>-2</sup>, <i>p</i>=0.13); CD34+/CD133+/KDR+: 1.84 [1.28-2.39]×10<sup>-2</sup> vs. 2.17 [1.64-2.70]×10<sup>-2</sup>, <i>p</i>=0.43).</p><p><strong>Conclusions-: </strong>Among healthy adults, habitual SED was not associated with markers of endothelial cell health.</p>\",\"PeriodicalId\":75243,\"journal\":{\"name\":\"Translational journal of the American College of Sports Medicine\",\"volume\":\"5 12\",\"pages\":\"\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087243/pdf/nihms-1672155.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational journal of the American College of Sports Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1249/tjx.0000000000000138\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"SPORT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational journal of the American College of Sports Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1249/tjx.0000000000000138","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"SPORT SCIENCES","Score":null,"Total":0}
Associations Between Habitual Sedentary Behavior and Endothelial Cell Health.
Endothelial dysfunction is a mechanism that may explain the link between prolonged sedentary time and cardiovascular disease. However, the relation between habitual sedentary behavior (SED) and endothelial function has yet to be explored.
Purpose-: The purpose of this study was to examine the association of accelerometer-measured SED with markers of endothelial cell health.
Methods-: Healthy adult participants (n=83; 43.4% male; 25.5 ± 5.8 years old) were examined. SED was measured for 7-days by accelerometer. Endothelial function measures included endothelium-dependent vasodilation (EDV); endothelial microparticles (EMPs) [CD62E+ and CD31+/CD42- EMPs]; and endothelial progenitor cells (EPCs) [CD34+/CD133+/KDR+ and CD34+/KDR+EPCs]. Participants were classified as having low or high SED based on a median split.
Results-: Participants in the low and high SED group spent a mean ± SD of 8.6 ± 1.1 and 11.1 ± 1.0 h/day in SED, respectively. No significant differences between the low and high SED groups were detected in mean [95% confidence interval (CI)] EDV (2.51 [2.21-2.81] vs. 2.36 [2.07-2.64], p=0.50), EMPs (CD62E+: 6.70 [6.55-6.84] vs. 6.56 [6.42-6.69], p=0.20; CD31+/CD42‒: 6.26 [6.10-6.42] vs. 6.18 [6.03-6.33], p=0.50), or EPCs (CD34+/KDR+: 11.91 [9.23-14.48]×10-2 vs. 14.87 [12.41-17.32]×10-2, p=0.13); CD34+/CD133+/KDR+: 1.84 [1.28-2.39]×10-2 vs. 2.17 [1.64-2.70]×10-2, p=0.43).
Conclusions-: Among healthy adults, habitual SED was not associated with markers of endothelial cell health.
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