{"title":"艾滋病毒/艾滋病:疾病、治疗和预防的最新情况。","authors":"Praveen Kumar Gupta, Apoorva Saxena","doi":"10.1007/s40011-021-01237-y","DOIUrl":null,"url":null,"abstract":"<p><p>CCR5-delta 32 homozygous stem cell transplantation for HIV-infected individuals is being treated as a milestone in the global AIDS epidemic. Since 2008, when the second Berlin patient was cured from HIV after undergoing transplantation from a donor with delta-32 mutation, scientists are aiming for a long-term cure for the wider population. In 2019, a London patient became the second person to be free of HIV and came off the antiretroviral drugs completely. CCR5 gene is now being treated as a viable target for HIV treatment. It can be used in the treatment of HIV either through administration of drugs that bind to CCR5 and stop the receptor from working or through gene therapy to alter the CCR5 gene using CRISPR/Cas9 and prevent protein production. This review article aims to identify the obstacles and the need to overcome them in order to bridge the gap between current research and future potential cures for HIV.</p>","PeriodicalId":54564,"journal":{"name":"Proceedings of the National Academy of Sciences, India. Section B","volume":"91 3","pages":"495-510"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40011-021-01237-y","citationCount":"5","resultStr":"{\"title\":\"HIV/AIDS: Current Updates on the Disease, Treatment and Prevention.\",\"authors\":\"Praveen Kumar Gupta, Apoorva Saxena\",\"doi\":\"10.1007/s40011-021-01237-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>CCR5-delta 32 homozygous stem cell transplantation for HIV-infected individuals is being treated as a milestone in the global AIDS epidemic. Since 2008, when the second Berlin patient was cured from HIV after undergoing transplantation from a donor with delta-32 mutation, scientists are aiming for a long-term cure for the wider population. In 2019, a London patient became the second person to be free of HIV and came off the antiretroviral drugs completely. CCR5 gene is now being treated as a viable target for HIV treatment. It can be used in the treatment of HIV either through administration of drugs that bind to CCR5 and stop the receptor from working or through gene therapy to alter the CCR5 gene using CRISPR/Cas9 and prevent protein production. This review article aims to identify the obstacles and the need to overcome them in order to bridge the gap between current research and future potential cures for HIV.</p>\",\"PeriodicalId\":54564,\"journal\":{\"name\":\"Proceedings of the National Academy of Sciences, India. Section B\",\"volume\":\"91 3\",\"pages\":\"495-510\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/s40011-021-01237-y\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the National Academy of Sciences, India. Section B\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s40011-021-01237-y\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/4/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"Agricultural and Biological Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the National Academy of Sciences, India. Section B","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40011-021-01237-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/4/23 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
HIV/AIDS: Current Updates on the Disease, Treatment and Prevention.
CCR5-delta 32 homozygous stem cell transplantation for HIV-infected individuals is being treated as a milestone in the global AIDS epidemic. Since 2008, when the second Berlin patient was cured from HIV after undergoing transplantation from a donor with delta-32 mutation, scientists are aiming for a long-term cure for the wider population. In 2019, a London patient became the second person to be free of HIV and came off the antiretroviral drugs completely. CCR5 gene is now being treated as a viable target for HIV treatment. It can be used in the treatment of HIV either through administration of drugs that bind to CCR5 and stop the receptor from working or through gene therapy to alter the CCR5 gene using CRISPR/Cas9 and prevent protein production. This review article aims to identify the obstacles and the need to overcome them in order to bridge the gap between current research and future potential cures for HIV.
期刊介绍：
The Proceedings of the National Academy of Sciences, India, Section B: Biological Sciences, is one of the oldest journals of India, launched in the year 1930, by the National Academy of Sciences, India (the Oldest Science Academy of India). The research/review papers of different fields of science, e.g. Agriculture Sciences (Agriculture, Animal Husbandry, Fisheries, Forestry, Agric. Toxicology, Soil Science, Plant Protection, Post Harvest Technology, and Agricultural Engineering), Animal Sciences (Structural, Developmental, Functional, Genetical, Ecological, Behavioural, Taxonomical and Evolutionary Aspects), Biochemistry, Biophysics, Biotechnology (including Molecular and Cell Biology, Structural and Functional Studies, Microbiology and Immunology), Medical & Forensic Sciences (Basic and Clinical Medical Sciences, Pharmacology, Anthropology, Psychology and Forensic Sciences, Human genetics, Reproduction Biology, Neurosciences and Molecular Medicine) and Plant Sciences (Structural, Developmental, Functional, Genetical, Ecological, Taxonomical and Evolutionary Aspects), are published in this journal for dissemination of the scientific knowledge and research. The papers published are indexed/abstracted by the leading abstracting agencies of the world. The papers are published after critical review and editing by the eminent experts of the concerned subject area; therefore, the quality publication is assured once the paper is accepted by the learned referees.
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