慢性肾病猫模型尿排泄肝型脂肪酸结合蛋白的初步研究。

IF 1.1 4区农林科学 Q2 Veterinary

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire Pub Date : 2021-04-01

Akiko Watanabe, Keiichi Ohata, Tsuyoshi Oikawa, Takeshi Sugaya, Masao Miyazaki, Hiroshi Satoh, Masaaki Katayama

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引用次数: 0

摘要

尿肝型脂肪酸结合蛋白(uL-FABP)是监测人类慢性肾脏疾病(CKD)的临床有用的生物标志物。然而，长期监测CKD猫的uL-FABP尚未见报道。本初步研究的目的是探讨尿中L-FABP是否可以预测2只CKD模型猫的肾功能恶化。在1只肾功能恶化的猫中，尿肝型脂肪酸结合蛋白(uL-FABP)在标准肾脏生物标志物(包括血清肌酐、血尿素氮和对称二甲基精氨酸)之前升高，但在另一只肾功能稳定的猫中保持较低且相对稳定。我们的研究结果表明，uL-FABP是预测猫CKD进展的潜在临床生物标志物，就像它在人类中一样。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Preliminary study of urinary excretion of liver-type fatty acid-binding protein in a cat model of chronic kidney disease.

Urinary liver-type fatty acid-binding protein (uL-FABP) is a clinically useful biomarker for monitoring chronic kidney disease (CKD) in humans. However, long-term monitoring of uL-FABP in CKD cats has not been reported. The objective of this preliminary study was to investigate whether the urinary excretion of L-FABP could predict the deterioration of renal function in 2 CKD model cats. Urinary liver-type fatty acid-binding protein (uL-FABP) increased before standard renal biomarkers, including serum creatinine, blood urea nitrogen, and symmetric dimethylarginine, in 1 cat with deteriorating renal function, but remained low and relatively stable in another cat with stable renal function. Our results suggest that uL-FABP is a potential clinical biomarker for predicting the progression of CKD in cats, as it is in humans.

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来源期刊

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 农林科学-兽医学

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

>24 weeks

期刊介绍： The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.