纤维化间质性肺病患者的评估:土耳其- uip研究的初步结果

IF 0.8 Q4 RESPIRATORY SYSTEM

Turkish Thoracic Journal Pub Date : 2021-03-01 DOI:10.5152/TurkThoracJ.2021.20028

Musellim Benan, Mogulkoc Nesrin, Uzun Oguz, Tokgoz Akyil Fatma, Turktas Haluk, Ozdemir Kumbasar Ozlem, Okumus Gulfer, Ogus Candan, Dirol Hulya, Zamani Adil, Sevim Tulin, Annakkaya Ali Nihat, Ozyurek Berna Akinci, Hanta Ismail, Aydemir Yusuf, Cakir Edis Ebru, Kurt Bahar, Tertemiz Kemal Can, Tabak Levent, Yazici Onur, Erdogan Yurdanur, Ates Gungor, Turker Hatice, Salepci Banu, Hazar Armagan, Niksarlioglu Elif Yelda, Yılmaz Kara Bilge, Kokturk Nurdan, Kalpaklioglu Fusun, Uzel Isil, Ozsu Savas, Atahan Ersan, Fendoglu Turkan Zeynep, Yilmaz Sureyya, Basyigit Ilknur, Camsari Gungor, Tuncay Esin, Ucar Yilmazel Elif, Kanmaz Dilek, Ekici Aydanur, Topcu Fusun, Uzaslan Esra, Bozkus Fulsen, Argun Baris Serap, Duru Serap, Altinisik Goksel, Bingol Zuleyha, Tunaci Atadan, Savas Recep, Alper Fatih, Bayraktaroglu Selen, Selcuk Can Tuba, Demir Ali Arslan

{"title":"纤维化间质性肺病患者的评估:土耳其- uip研究的初步结果","authors":"Musellim Benan, Mogulkoc Nesrin, Uzun Oguz, Tokgoz Akyil Fatma, Turktas Haluk, Ozdemir Kumbasar Ozlem, Okumus Gulfer, Ogus Candan, Dirol Hulya, Zamani Adil, Sevim Tulin, Annakkaya Ali Nihat, Ozyurek Berna Akinci, Hanta Ismail, Aydemir Yusuf, Cakir Edis Ebru, Kurt Bahar, Tertemiz Kemal Can, Tabak Levent, Yazici Onur, Erdogan Yurdanur, Ates Gungor, Turker Hatice, Salepci Banu, Hazar Armagan, Niksarlioglu Elif Yelda, Yılmaz Kara Bilge, Kokturk Nurdan, Kalpaklioglu Fusun, Uzel Isil, Ozsu Savas, Atahan Ersan, Fendoglu Turkan Zeynep, Yilmaz Sureyya, Basyigit Ilknur, Camsari Gungor, Tuncay Esin, Ucar Yilmazel Elif, Kanmaz Dilek, Ekici Aydanur, Topcu Fusun, Uzaslan Esra, Bozkus Fulsen, Argun Baris Serap, Duru Serap, Altinisik Goksel, Bingol Zuleyha, Tunaci Atadan, Savas Recep, Alper Fatih, Bayraktaroglu Selen, Selcuk Can Tuba, Demir Ali Arslan","doi":"10.5152/TurkThoracJ.2021.20028","DOIUrl":null,"url":null,"abstract":"Objective: Differential diagnosis of idiopathic pulmonary fibrosis (IPF) is important among fibrotic interstitial lung diseases (ILD). This study aimed to evaluate the rate of IPF in patients with fibrotic ILD and to determine the clinical-laboratory features of patients with and without IPF that would provide the differential diagnosis of IPF.Material and methods: The study included the patients with the usual interstitial pneumonia (UIP) pattern or possible UIP pattern on thorax high-resolution computed tomography, and/or UIP pattern, probable UIP or possible UIP pattern at lung biopsy according to the 2011 ATS/ERS/JRS/ALAT guidelines. Demographics and clinical and radiological data of the patients were recorded. All data recorded by researchers was evaluated by radiology and the clinical decision board.Results: A total of 336 patients (253 men, 83 women, age 65.8±9.0 years) were evaluated. Of the patients with sufficient data for diagnosis (n=300), the diagnosis was IPF in 121 (40.3%), unclassified idiopathic interstitial pneumonia in 50 (16.7%), combined pulmonary fibrosis and emphysema (CPFE) in 40 (13.3%), and lung involvement of connective tissue disease (CTD) in 16 (5.3%). When 29 patients with definite IPF features were added to the patients with CPFE, the total number of IPF patients reached 150 (50%). Rate of male sex (p<0.001), smoking history (p<0.001), and the presence of clubbing (p=0.001) were significantly high in patients with IPF. None of the women <50 years and none of the men <50 years of age without a smoking history were diagnosed with IPF. Presence of at least 1 of the symptoms suggestive of CTD, erythrocyte sedimentation rate (ESR), and antinuclear antibody (FANA) positivity rates were significantly higher in the non-IPF group (p<0.001, p=0.029, p=0.009, respectively).Conclusion: The rate of IPF among patients with fibrotic ILD was 50%. In the differential diagnosis of IPF, sex, smoking habits, and the presence of clubbing are important. The presence of symptoms related to CTD, ESR elevation, and FANA positivity reduce the likelihood of IPF.","PeriodicalId":37452,"journal":{"name":"Turkish Thoracic Journal","volume":"22 2","pages":"102-109"},"PeriodicalIF":0.8000,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051299/pdf/ttj-22-2-102.pdf","citationCount":"0","resultStr":"{\"title\":\"Evaluation of Patients with Fibrotic Interstitial Lung Disease: Preliminary results from the Turk-UIP Study.\",\"authors\":\"Musellim Benan, Mogulkoc Nesrin, Uzun Oguz, Tokgoz Akyil Fatma, Turktas Haluk, Ozdemir Kumbasar Ozlem, Okumus Gulfer, Ogus Candan, Dirol Hulya, Zamani Adil, Sevim Tulin, Annakkaya Ali Nihat, Ozyurek Berna Akinci, Hanta Ismail, Aydemir Yusuf, Cakir Edis Ebru, Kurt Bahar, Tertemiz Kemal Can, Tabak Levent, Yazici Onur, Erdogan Yurdanur, Ates Gungor, Turker Hatice, Salepci Banu, Hazar Armagan, Niksarlioglu Elif Yelda, Yılmaz Kara Bilge, Kokturk Nurdan, Kalpaklioglu Fusun, Uzel Isil, Ozsu Savas, Atahan Ersan, Fendoglu Turkan Zeynep, Yilmaz Sureyya, Basyigit Ilknur, Camsari Gungor, Tuncay Esin, Ucar Yilmazel Elif, Kanmaz Dilek, Ekici Aydanur, Topcu Fusun, Uzaslan Esra, Bozkus Fulsen, Argun Baris Serap, Duru Serap, Altinisik Goksel, Bingol Zuleyha, Tunaci Atadan, Savas Recep, Alper Fatih, Bayraktaroglu Selen, Selcuk Can Tuba, Demir Ali Arslan\",\"doi\":\"10.5152/TurkThoracJ.2021.20028\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: Differential diagnosis of idiopathic pulmonary fibrosis (IPF) is important among fibrotic interstitial lung diseases (ILD). This study aimed to evaluate the rate of IPF in patients with fibrotic ILD and to determine the clinical-laboratory features of patients with and without IPF that would provide the differential diagnosis of IPF.Material and methods: The study included the patients with the usual interstitial pneumonia (UIP) pattern or possible UIP pattern on thorax high-resolution computed tomography, and/or UIP pattern, probable UIP or possible UIP pattern at lung biopsy according to the 2011 ATS/ERS/JRS/ALAT guidelines. Demographics and clinical and radiological data of the patients were recorded. All data recorded by researchers was evaluated by radiology and the clinical decision board.Results: A total of 336 patients (253 men, 83 women, age 65.8±9.0 years) were evaluated. Of the patients with sufficient data for diagnosis (n=300), the diagnosis was IPF in 121 (40.3%), unclassified idiopathic interstitial pneumonia in 50 (16.7%), combined pulmonary fibrosis and emphysema (CPFE) in 40 (13.3%), and lung involvement of connective tissue disease (CTD) in 16 (5.3%). When 29 patients with definite IPF features were added to the patients with CPFE, the total number of IPF patients reached 150 (50%). Rate of male sex (p<0.001), smoking history (p<0.001), and the presence of clubbing (p=0.001) were significantly high in patients with IPF. None of the women <50 years and none of the men <50 years of age without a smoking history were diagnosed with IPF. Presence of at least 1 of the symptoms suggestive of CTD, erythrocyte sedimentation rate (ESR), and antinuclear antibody (FANA) positivity rates were significantly higher in the non-IPF group (p<0.001, p=0.029, p=0.009, respectively).Conclusion: The rate of IPF among patients with fibrotic ILD was 50%. In the differential diagnosis of IPF, sex, smoking habits, and the presence of clubbing are important. The presence of symptoms related to CTD, ESR elevation, and FANA positivity reduce the likelihood of IPF.\",\"PeriodicalId\":37452,\"journal\":{\"name\":\"Turkish Thoracic Journal\",\"volume\":\"22 2\",\"pages\":\"102-109\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2021-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051299/pdf/ttj-22-2-102.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Turkish Thoracic Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5152/TurkThoracJ.2021.20028\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkish Thoracic Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5152/TurkThoracJ.2021.20028","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}

引用次数: 0

摘要

目的:特发性肺纤维化(IPF)的鉴别诊断在纤维化间质性肺疾病(ILD)中具有重要意义。本研究旨在评估纤维化性ILD患者的IPF发生率，并确定有和无IPF患者的临床-实验室特征，以提供IPF的鉴别诊断。材料和方法:本研究纳入了根据2011年ATS/ERS/JRS/ALAT指南在胸部高分辨率计算机断层扫描上表现为通常间质性肺炎(UIP)或可能的UIP型，和/或肺活检表现为UIP型、可能的UIP型或可能的UIP型的患者。记录患者的人口统计学、临床和放射学资料。研究人员记录的所有数据均由放射学和临床决策委员会进行评估。结果:共纳入336例患者，其中男性253例，女性83例，年龄65.8±9.0岁。在有足够诊断资料的患者中(n=300)，诊断为IPF 121例(40.3%)，未分类特发性间质性肺炎50例(16.7%)，合并肺纤维化和肺气肿(CPFE) 40例(13.3%)，肺部累及结缔组织病(CTD) 16例(5.3%)。在CPFE患者中加上29例明确IPF特征的患者，IPF患者总数达到150例(50%)。结论:纤维化性ILD患者IPF发生率为50%。在IPF的鉴别诊断中，性别、吸烟习惯和俱乐部的存在是重要的。与CTD、ESR升高和FANA阳性相关的症状的存在降低了IPF的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Evaluation of Patients with Fibrotic Interstitial Lung Disease: Preliminary results from the Turk-UIP Study.

Objective: Differential diagnosis of idiopathic pulmonary fibrosis (IPF) is important among fibrotic interstitial lung diseases (ILD). This study aimed to evaluate the rate of IPF in patients with fibrotic ILD and to determine the clinical-laboratory features of patients with and without IPF that would provide the differential diagnosis of IPF.

Material and methods: The study included the patients with the usual interstitial pneumonia (UIP) pattern or possible UIP pattern on thorax high-resolution computed tomography, and/or UIP pattern, probable UIP or possible UIP pattern at lung biopsy according to the 2011 ATS/ERS/JRS/ALAT guidelines. Demographics and clinical and radiological data of the patients were recorded. All data recorded by researchers was evaluated by radiology and the clinical decision board.

Results: A total of 336 patients (253 men, 83 women, age 65.8±9.0 years) were evaluated. Of the patients with sufficient data for diagnosis (n=300), the diagnosis was IPF in 121 (40.3%), unclassified idiopathic interstitial pneumonia in 50 (16.7%), combined pulmonary fibrosis and emphysema (CPFE) in 40 (13.3%), and lung involvement of connective tissue disease (CTD) in 16 (5.3%). When 29 patients with definite IPF features were added to the patients with CPFE, the total number of IPF patients reached 150 (50%). Rate of male sex (p<0.001), smoking history (p<0.001), and the presence of clubbing (p=0.001) were significantly high in patients with IPF. None of the women <50 years and none of the men <50 years of age without a smoking history were diagnosed with IPF. Presence of at least 1 of the symptoms suggestive of CTD, erythrocyte sedimentation rate (ESR), and antinuclear antibody (FANA) positivity rates were significantly higher in the non-IPF group (p<0.001, p=0.029, p=0.009, respectively).

Conclusion: The rate of IPF among patients with fibrotic ILD was 50%. In the differential diagnosis of IPF, sex, smoking habits, and the presence of clubbing are important. The presence of symptoms related to CTD, ESR elevation, and FANA positivity reduce the likelihood of IPF.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Turkish Thoracic Journal Medicine-Pulmonary and Respiratory Medicine

CiteScore

1.40

自引率

11.10%

发文量

期刊介绍： Turkish Thoracic Journal (Turk Thorac J) is the double-blind, peer-reviewed, open access, international publication organ of Turkish Thoracic Society. The journal is a quarterly publication, published on January, April, July, and October and its publication language is English. Turkish Thoracic Journal started its publication life following the merger of two journals which were published under the titles “Turkish Respiratory Journal” and “Toraks Journal” until 2007. Archives of both journals were passed on to the Turkish Thoracic Journal. The aim of the journal is to convey scientific developments and to create a dynamic discussion platform about pulmonary diseases. With this intent, the journal accepts articles from all related scientific areas that address adult and pediatric pulmonary diseases, as well as thoracic imaging, environmental and occupational disorders, intensive care, sleep disorders and thoracic surgery. Clinical and research articles, reviews, statements of agreement or disagreement on controversial issues, national and international consensus reports, abstracts and comments of important international articles, interesting case reports, writings related to clinical and practical applications, letters to the editor, and editorials are accepted.