{"title":"人类生殖系基因组编辑:基因组编辑原因的本质","authors":"Robert Sparrow","doi":"10.1080/15265161.2021.1907480","DOIUrl":null,"url":null,"abstract":"<p><p>Ever since the publication of Derek Parfit's <i>Reasons and Persons,</i> bioethicists have tended to distinguish between two different ways in which reproductive technologies may have implications for the welfare of future persons. Some interventions harm or benefit particular individuals: they are \"person affecting.\" Other interventions determine which individual, of a number of possible individuals, comes into existence: they are \"identity affecting\" and raise the famous \"non-identity problem.\" For the past several decades, bioethical debate has, for the most part, proceeded on the assumption that direct genetic modification of human embryos would be person affecting. In this paper, I argue that that genome editing is highly unlikely to be person affecting for the foreseeable future and, as a result, will neither benefit nor harm edited individuals.</p>","PeriodicalId":145777,"journal":{"name":"The American journal of bioethics : AJOB","volume":" ","pages":"4-15"},"PeriodicalIF":0.0000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15265161.2021.1907480","citationCount":"24","resultStr":"{\"title\":\"Human Germline Genome Editing: On the Nature of Our Reasons to Genome Edit.\",\"authors\":\"Robert Sparrow\",\"doi\":\"10.1080/15265161.2021.1907480\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ever since the publication of Derek Parfit's <i>Reasons and Persons,</i> bioethicists have tended to distinguish between two different ways in which reproductive technologies may have implications for the welfare of future persons. Some interventions harm or benefit particular individuals: they are \\\"person affecting.\\\" Other interventions determine which individual, of a number of possible individuals, comes into existence: they are \\\"identity affecting\\\" and raise the famous \\\"non-identity problem.\\\" For the past several decades, bioethical debate has, for the most part, proceeded on the assumption that direct genetic modification of human embryos would be person affecting. In this paper, I argue that that genome editing is highly unlikely to be person affecting for the foreseeable future and, as a result, will neither benefit nor harm edited individuals.</p>\",\"PeriodicalId\":145777,\"journal\":{\"name\":\"The American journal of bioethics : AJOB\",\"volume\":\" \",\"pages\":\"4-15\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/15265161.2021.1907480\",\"citationCount\":\"24\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The American journal of bioethics : AJOB\",\"FirstCategoryId\":\"98\",\"ListUrlMain\":\"https://doi.org/10.1080/15265161.2021.1907480\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/4/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The American journal of bioethics : AJOB","FirstCategoryId":"98","ListUrlMain":"https://doi.org/10.1080/15265161.2021.1907480","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/4/19 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 24
摘要
自从德里克·帕菲特(Derek Parfit)的《理由与人》(Reasons and Persons)出版以来,生物伦理学家就倾向于区分生殖技术可能对未来人类福祉产生影响的两种不同方式。一些干预措施对特定的个体有害或有益:它们是“影响个人的”。其他干预决定了在许多可能的个体中,哪个个体会出现:它们是“身份影响”,并引发了著名的“非身份问题”。在过去的几十年里,关于生物伦理的争论在很大程度上是建立在对人类胚胎进行直接基因改造会对人产生影响的假设之上的。在这篇论文中,我认为,在可预见的未来,基因组编辑不太可能对人类产生影响,因此,它既不会给被编辑的个体带来好处,也不会对其造成伤害。
Human Germline Genome Editing: On the Nature of Our Reasons to Genome Edit.
Ever since the publication of Derek Parfit's Reasons and Persons, bioethicists have tended to distinguish between two different ways in which reproductive technologies may have implications for the welfare of future persons. Some interventions harm or benefit particular individuals: they are "person affecting." Other interventions determine which individual, of a number of possible individuals, comes into existence: they are "identity affecting" and raise the famous "non-identity problem." For the past several decades, bioethical debate has, for the most part, proceeded on the assumption that direct genetic modification of human embryos would be person affecting. In this paper, I argue that that genome editing is highly unlikely to be person affecting for the foreseeable future and, as a result, will neither benefit nor harm edited individuals.