2 型糖尿病和肥胖症患者血浆 12,13-diHOME 水平与非酒精性脂肪肝之间的关系。

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM
Minerva endocrinology Pub Date : 2025-03-01 Epub Date: 2021-04-15 DOI:10.23736/S2724-6507.21.03424-6
Sichao Wang, Weixia Sun, Yiping Cheng, Lei Wang, Shizhan Ma, Fei Jing, Xiujuan Zhang, Xinli Zhou
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引用次数: 0

摘要

目的:12,13-二羟基-9Z-十八碳烯酸(12,13-diHOME)是新发现的脂肪因子之一。本研究旨在调查 12,13-diHOME 是否与中国 2 型糖尿病(T2DM)和肥胖人群中非酒精性脂肪肝(NAFLD)的相关代谢指标有关:这项横断面研究共纳入 202 名 T2DM 患者。收集了人体测量参数、12,13-diHOME、血清脂质水平、空腹血糖(FBG)、血清糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、胰岛素抵抗稳态模型评估(HOMA-IR)、肝肾功能参数。非酒精性脂肪肝根据腹部超声波检查结果进行诊断。采用计算机辅助超声定量法评估肝脏脂肪含量(LFC):脂肪肝患者为 139 人(68.81%),非脂肪肝患者为 63 人(31.19%)。非酒精性脂肪肝患者的体重指数(BMI)、舒张压、血清丙氨酸氨基转移酶(ALT)、甘油三酯(TG)、HOMA-IR、LFC均较高,P<0.05。但血浆中的 12,13-diHOME 水平没有发现明显差异(P=0.967),尽管其水平趋势在非NAFLD 组中更高。血浆 12,13-diHOME 与天冬氨酸氨基转移酶 (AST)、总胆固醇 (TC)、高密度脂蛋白胆固醇 (HDLC)、血尿素氮 (BUN)、游离脂肪酸 (FFA)、C 肽、FINS 和 HOMAIR 呈正相关。它与身高、体重、肾小球滤过率(eGFR)和 HbA1c 呈负相关:尽管 12,13-diHOME 与 AST、TC、HDL-C、BUN、FFA、C 肽、FINS、HOMA-IR、eGFR 和 HbA1c 相关,但两组之间的 12,13-diHOME 水平没有显著差异。不过,对这种新发现的脂肪因子还需要进行更多的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship between plasma 12,13-diHOME level and nonalcoholic fatty liver disease in patients with type 2 diabetes and obesity.

Background: 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) was one of the newly found lipokines. The goal of this study was to investigate whether the 12,13-diHOME was associated with related metabolic markers of nonalcoholic fatty liver disease (NAFLD) in a Chinese population with type 2 diabetes (T2DM) and obesity.

Methods: This cross-sectional study enrolled 202 subjects with T2DM. Anthropometric parameters, 12,13-diHOME, serum lipids levels, fasting blood-glucose (FBG), serum glycosylated hemoglobin (HbA1c), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), liver and kidney function parameters were collected. NAFLD was diagnosed based on abdominal ultrasonography examination results. A computer-aided ultrasound quantitative method was applied to evaluate the liver fat content (LFC).

Results: The number of the patients with fatty liver was 139 (68.81%) and those with non-fatty liver was 63 (31.19%). Subjects with NAFLD had a higher body mass index (BMI), diastolic blood pressure, serum alanine aminotransferase (ALT), triglyceride (TG), HOMA-IR, LFC, P<0.05 for all. But no significant difference was found in plasma 12,13-diHOME level (P=0.967), though its level trend was higher in non-NAFLD group. Plasma 12,13-diHOME was positively correlated with aspartate aminotransferase (AST), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), blood urea nitrogen (BUN), free fatty acid (FFA), C-peptide, FINS and HOMA-IR. It was negatively correlated with height, body weight, glomerular filtration rate (eGFR) and HbA1c.

Conclusions: Although 12,13-diHOME was correlated with AST, TC, HDL-C, BUN, FFA, C-peptide, FINS, HOMA-IR, eGFR and HbA1c, there was no significant difference in 12,13-diHOME level between the two groups. However, more research should be carried on about this newly-found lipokine.

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CiteScore
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