结合流固耦合和微循环的动脉血流动力学数值模拟。

Q1 Mathematics
Fan He, Lu Hua, Tingting Guo
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引用次数: 3

摘要

背景:在过去的几十年里,动脉壁顺应性对血流的影响已经通过流固相互作用被揭示出来。然而,以往的研究并未考虑微循环。事实上,微循环在调节血液流动中起着关键作用。因此,将微循环纳入动脉血流动力学研究是十分必要的。目的:本研究的主要目的是研究壁面顺应性对流动特性的影响,并在考虑微循环的情况下,将这些流动变量与刚性壁面进行比较。方法:建立了结合流固耦合和微循环的动脉血流动力学数值模型。在理想模型中,采用一种新的出口边界条件来规定微循环。结果:本研究的新发现是,考虑微循环的壁面柔顺性与刚性壁面相比,导致壁面剪切应力增加,而传统的结果是,当出口指定恒定或随时间变化的压力时,壁面柔顺性使壁面剪切应力减小。结论:本工作为生理和现实边界条件下的血流动力学研究提供了有价值的研究,并证明基于该模型的壁面顺应性可能对壁面剪切应力产生积极影响。本文提出的方法可用于实际模型仿真。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Numerical modeling in arterial hemodynamics incorporating fluid-structure interaction and microcirculation.

Numerical modeling in arterial hemodynamics incorporating fluid-structure interaction and microcirculation.

Numerical modeling in arterial hemodynamics incorporating fluid-structure interaction and microcirculation.

Numerical modeling in arterial hemodynamics incorporating fluid-structure interaction and microcirculation.

Background: The effects of arterial wall compliance on blood flow have been revealed using fluid-structure interaction in last decades. However, microcirculation is not considered in previous researches. In fact, microcirculation plays a key role in regulating blood flow. Therefore, it is very necessary to involve microcirculation in arterial hemodynamics.

Objective: The main purpose of the present study is to investigate how wall compliance affects the flow characteristics and to establish the comparisons of these flow variables with rigid wall when microcirculation is considered.

Methods: We present numerical modeling in arterial hemodynamics incorporating fluid-structure interaction and microcirculation. A novel outlet boundary condition is employed to prescribe microcirculation in an idealised model.

Results: The novel finding in this work is that wall compliance under the consideration of microcirculation leads to the increase of wall shear stress in contrast to rigid wall, contrary to the traditional result that wall compliance makes wall shear stress decrease when a constant or time dependent pressure is specified at an outlet.

Conclusions: This work provides the valuable study of hemodynamics under physiological and realistic boundary conditions and proves that wall compliance may have a positive impact on wall shear stress based on this model. This methodology in this paper could be used in real model simulations.

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来源期刊
Theoretical Biology and Medical Modelling
Theoretical Biology and Medical Modelling MATHEMATICAL & COMPUTATIONAL BIOLOGY-
自引率
0.00%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Theoretical Biology and Medical Modelling is an open access peer-reviewed journal adopting a broad definition of "biology" and focusing on theoretical ideas and models associated with developments in biology and medicine. Mathematicians, biologists and clinicians of various specialisms, philosophers and historians of science are all contributing to the emergence of novel concepts in an age of systems biology, bioinformatics and computer modelling. This is the field in which Theoretical Biology and Medical Modelling operates. We welcome submissions that are technically sound and offering either improved understanding in biology and medicine or progress in theory or method.
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