将直接传播、蚁群传播和家庭结构相结合的流行病模型应用于 COVID-19。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2021-01-01 Epub Date: 2021-01-05 DOI:10.1186/s13362-020-00097-x
Karunia Putra Wijaya, Naleen Ganegoda, Yashika Jayathunga, Thomas Götz, Moritz Schäfer, Peter Heidrich
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引用次数: 0

摘要

本文强调其基础贡献在于一个新的 SIR 型模型,包括直接传播和飞沫传播以及不同家庭结构的影响。该模型的推导受到典型空气传播疾病固有的几个机理过程的影响。在直接传播中包含了最小接触半径的概念,便于对物理距离进行论证。由于熏蒸传播在很大程度上与前喷嚏痕迹有关,系统的矢量场自然包含一个具有时间延迟的积分核,表明未被发现和未检疫的无症状病例在累积历史表面污染中的贡献。然后,我们将住户内部和住户之间的不同传播程序纳入其中,从而增加了复杂性。对于空气传播疾病,住户内部的相互作用在疾病传播过程中发挥着重要作用,从而在全国范围内产生影响。为了纳入家庭结构的影响,我们采取了两个步骤。第一步是将整个分区(易感者、暴露者、无症状者、有症状者、康复者、死亡者)细分到家庭层面,并区分家庭内部和家庭之间直接传播的不同感染率。在预先设定的条件和假设下,可以将家庭层面的治理系统提升到社区层面。第二步是将治理系统提升到国家层面,在国家层面,最终状态变量估算的是全国所有分区的总人数。与家庭结构相关的两个关键属性(当地家庭数量和家庭成员数量)可以有效地将国家划分为疾病有效传播的低风险国家或高风险国家。计算基本繁殖数,并正确引用其生物学含义。还提到了解决 DIDE 系统和参数估计问题的数值方法。我们的最优模型解决方案与德国和斯里兰卡的 COVID-19 活动病例和相关死亡数据集在早期感染时非常吻合,使我们能够假设这两个国家的几种无法观察到的情况。我们将重点放在扩大最小接触半径和降低个人活动强度上,从而综合出了一些关键参数,告诉我们该如何实践。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19.

An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19.

An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19.

An epidemic model integrating direct and fomite transmission as well as household structure applied to COVID-19.

This paper stresses its base contribution on a new SIR-type model including direct and fomite transmission as well as the effect of distinct household structures. The model derivation is modulated by several mechanistic processes inherent from typical airborne diseases. The notion of minimum contact radius is included in the direct transmission, facilitating the arguments on physical distancing. As fomite transmission heavily relates to former-trace of sneezes, the vector field of the system naturally contains an integral kernel with time delay indicating the contribution of undetected and non-quarantined asymptomatic cases in accumulating the historical contamination of surfaces. We then increase the complexity by including the different transmission routines within and between households. For airborne diseases, within-household interactions play a significant role in the propagation of the disease rendering countrywide effect. Two steps were taken to include the effect of household structure. The first step subdivides the entire compartments (susceptible, exposed, asymptomatic, symptomatic, recovered, death) into the household level and different infection rates for the direct transmission within and between households were distinguished. Under predefined conditions and assumptions, the governing system on household level can be raised to the community level. The second step then raises the governing system to the country level, where the final state variables estimate the total individuals from all compartments in the country. Two key attributes related to the household structure (number of local households and number of household members) effectively classify countries to be of low or high risk in terms of effective disease propagation. The basic reproductive number is calculated and its biological meaning is invoked properly. The numerical methods for solving the DIDE-system and the parameter estimation problem were mentioned. Our optimal model solutions are in quite good agreement with datasets of COVID-19 active cases and related deaths from Germany and Sri Lanka in early infection, allowing us to hypothesize several unobservable situations in the two countries. Focusing on extending minimum contact radius and reducing the intensity of individual activities, we were able to synthesize the key parameters telling what to practice.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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