营养表观遗传学的新进展——一个旧观念的新视角。经验教训、局限性和未来方向。

IF 3.2 Q2 GENETICS & HEREDITY
Epigenetics Insights Pub Date : 2020-12-18 eCollection Date: 2020-01-01 DOI:10.1177/2516865720981924
Lynda Sedley
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引用次数: 11

摘要

营养表观遗传学是一个快速发展的研究领域,基因组的自然调节是一种非侵入性、可持续的、个性化的慢性病管理基因编辑替代方案。遗传差异和表观遗传不灵活性导致基因表达异常,差异或异常甲基化模式占绝大多数疾病。对生物进化和环境对表观遗传学和自然选择的影响的不断扩大的理解需要重新学习曾经被认为是很好理解的概念。本研究探索了不太了解的表观遗传修饰(如泛素化、亚硝基化、糖基化、磷酸化和5 -羟色胺化)自然调节的潜力,结论是未被重视的乙酰化和线粒体依赖的下游表观遗传翻译后修饰可能是表观基因组层次的顶峰,对最佳健康至关重要,包括可持续的细胞能量生产。强调经验教训,这一概念探索提供了甲基化的新视角,展示了环境甲烷的增加如何驱动内源性甲基合成的进化下调,并展示了表观遗传机制如何具有细胞特异性,使甲基辅助因子的补充在整个分化过程中不可预测。对表观基因组层级的干扰可能导致表观遗传的不灵活性,症状缓解和疾病同时发生,并可能导致神经系统疾病(如自闭症谱系障碍)的发病率增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Advances in Nutritional Epigenetics-A Fresh Perspective for an Old Idea. Lessons Learned, Limitations, and Future Directions.

Advances in Nutritional Epigenetics-A Fresh Perspective for an Old Idea. Lessons Learned, Limitations, and Future Directions.

Advances in Nutritional Epigenetics-A Fresh Perspective for an Old Idea. Lessons Learned, Limitations, and Future Directions.

Advances in Nutritional Epigenetics-A Fresh Perspective for an Old Idea. Lessons Learned, Limitations, and Future Directions.

Nutritional epigenetics is a rapidly expanding field of research, and the natural modulation of the genome is a non-invasive, sustainable, and personalized alternative to gene-editing for chronic disease management. Genetic differences and epigenetic inflexibility resulting in abnormal gene expression, differential or aberrant methylation patterns account for the vast majority of diseases. The expanding understanding of biological evolution and the environmental influence on epigenetics and natural selection requires relearning of once thought to be well-understood concepts. This research explores the potential for natural modulation by the less understood epigenetic modifications such as ubiquitination, nitrosylation, glycosylation, phosphorylation, and serotonylation concluding that the under-appreciated acetylation and mitochondrial dependant downstream epigenetic post-translational modifications may be the pinnacle of the epigenomic hierarchy, essential for optimal health, including sustainable cellular energy production. With an emphasis on lessons learned, this conceptional exploration provides a fresh perspective on methylation, demonstrating how increases in environmental methane drive an evolutionary down regulation of endogenous methyl groups synthesis and demonstrates how epigenetic mechanisms are cell-specific, making supplementation with methyl cofactors throughout differentiation unpredictable. Interference with the epigenomic hierarchy may result in epigenetic inflexibility, symptom relief and disease concomitantly and may be responsible for the increased incidence of neurological disease such as autism spectrum disorder.

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来源期刊
Epigenetics Insights
Epigenetics Insights GENETICS & HEREDITY-
CiteScore
5.10
自引率
0.00%
发文量
10
审稿时长
8 weeks
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