非手术治疗对牙周病患者唾液HGF水平的影响:一项准实验研究。

Dalip Alreja, Jyoti R Rao, Sakshi Kataria, Dhaval A Faterpenkar
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引用次数: 1

摘要

目的:评估非手术治疗对牙周病患者唾液肝细胞生长因子(sHGF)水平的影响:一项准实验研究。方法:81例患者(年龄30 ~ 70岁)根据牙龈指数、探诊深度、临床附着丧失和骨质流失的影像学证据分为健康组(I组)、牙龈炎组(II组)和慢性牙周炎组(III组),并在基线时采集唾液样本。8周时,在进行牙周非手术治疗后,再次采集II组和III组患者的唾液样本。采用酶联免疫吸附试验(ELISA)测定HGF水平。各组临床参数及HGF水平采用单因素方差分析(ANOVA),采用SPSS 17版本。结果:在基线时,III组唾液中HGF平均浓度最高(3455.83±1463.44 pg/mL), I组最低(469.43±317.13 pg/mL)。牙周非手术治疗后,III组和II组平均HGF浓度显著降低(p < 0.05)。临床参数与HGF水平也有显著正相关(p < 0.05)。结论:HGF浓度与牙周病的进展呈正相关。临床意义:非手术牙周治疗后,HGF水平显著下降,提示HGF可用于监测对牙周治疗的反应。文章引用方式:Alreja D, Rao JR, Kataria S等。非手术治疗对牙周病患者唾液HGF水平的影响:一项准实验研究。中华肝病与胃肠病杂志;2020;10(2):51-55。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of Nonsurgical Treatment on Salivary HGF Levels in Population with Periodontal Disease: A Quasi-experimental Study.

Effect of Nonsurgical Treatment on Salivary HGF Levels in Population with Periodontal Disease: A Quasi-experimental Study.

Aim: To assess the effect of nonsurgical treatment on salivary hepatocyte growth factor (sHGF) levels in a population with periodontal disease: a quasi-experimental study.

Methods: Eighty-one patients (aged 30-70 years) were divided into three groups based on the gingival index, probing depth, clinical attachment loss, and radiographic evidence of bone loss: healthy (group I), gingivitis (group II), and chronic periodontitis (group III). Saliva samples were collected from these groups at baseline. At 8 weeks, saliva samples were collected again from group II and group III after the patients went through nonsurgical periodontal treatment. The levels of HGF were estimated using enzyme-linked immunosorbent assay (ELISA). The clinical parameters and HGF levels among all groups were analyzed using a one-way analysis of variance (ANOVA) using SPSS 17 version.

Results: At baseline, the highest mean HGF concentration in saliva was observed for group III (3455.83 ± 1463.44 pg/mL), and the least in group I (469.43 ± 317.13 pg/mL). Following nonsurgical periodontal treatment, the mean HGF concentration decreased significantly in group III and group II (p < 0.05). A significant positive correlation between clinical parameters and HGF levels was also seen (p < 0.05).

Conclusion: HGF concentration showed a positive correlation with the progression of periodontal disease.

Clinical significance: Following nonsurgical periodontal therapy, the levels of HGF decreased significantly, suggesting that HGF could be useful for monitoring the response to periodontal therapy.

How to cite this article: Alreja D, Rao JR, Kataria S, et al. Effect of Nonsurgical Treatment on Salivary HGF Levels in Population with Periodontal Disease: A Quasi-experimental Study. Euroasian J Hepato-Gastroenterol 2020;10(2):51-55.

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