Kjersti Johnsrud, Therese Seierstad, David Russell, Mona-Elisabeth Revheim
{"title":"18F-FDG PET/CT定量颈动脉斑块炎症的读者间一致。","authors":"Kjersti Johnsrud, Therese Seierstad, David Russell, Mona-Elisabeth Revheim","doi":"10.1177/2048004020980941","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>A significant proportion of ischemic strokes are caused by emboli from unstable atherosclerotic carotid artery plaques. Inflammation is a key feature of plaque instability. Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-(<sup>18</sup>F)-fluoro-D-glucose (<sup>18</sup>F-FDG) is a promising technique to quantify plaque inflammation, but a consensus on the methodology has not been established. High inter-reader agreement is essential if <sup>18</sup>F-FDG PET/CT is to be used as a clinical tool for the assessment of unstable plaques and stroke risk.</p><p><strong>Methods: </strong>We assessed the inter-reader variability of different methods for quantification of <sup>18</sup>F-FDG uptake in 43 patients with carotid artery stenosis ≥70%. Two independent readers delineated the plaque and collected maximum standardized uptake value (SUV<sub>max</sub>) from all axial PET slices containing the atherosclerotic plaque.</p><p><strong>Results: </strong>Uptake values with and without background correction were calculated and intraclass correlation coefficients were highest for uncorrected uptake values (0.97-0.98) followed by those background corrected by subtraction (0.89-0.94) and lowest for those background corrected by division (0.74-0.79).</p><p><strong>Conclusion: </strong>Quantification methods without background correction have the highest inter-reader agreement for <sup>18</sup>F-FDG PET of carotid artery plaque inflammation. The use of the single highest uptake value (max SUV<sub>max</sub>) from the plaque will facilitate the method's clinical utility in stroke prevention.</p>","PeriodicalId":30457,"journal":{"name":"JRSM Cardiovascular Disease","volume":" ","pages":"2048004020980941"},"PeriodicalIF":1.5000,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2048004020980941","citationCount":"3","resultStr":"{\"title\":\"Inter-reader agreement of <sup>18</sup>F-FDG PET/CT for the quantification of carotid artery plaque inflammation.\",\"authors\":\"Kjersti Johnsrud, Therese Seierstad, David Russell, Mona-Elisabeth Revheim\",\"doi\":\"10.1177/2048004020980941\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>A significant proportion of ischemic strokes are caused by emboli from unstable atherosclerotic carotid artery plaques. Inflammation is a key feature of plaque instability. Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-(<sup>18</sup>F)-fluoro-D-glucose (<sup>18</sup>F-FDG) is a promising technique to quantify plaque inflammation, but a consensus on the methodology has not been established. High inter-reader agreement is essential if <sup>18</sup>F-FDG PET/CT is to be used as a clinical tool for the assessment of unstable plaques and stroke risk.</p><p><strong>Methods: </strong>We assessed the inter-reader variability of different methods for quantification of <sup>18</sup>F-FDG uptake in 43 patients with carotid artery stenosis ≥70%. Two independent readers delineated the plaque and collected maximum standardized uptake value (SUV<sub>max</sub>) from all axial PET slices containing the atherosclerotic plaque.</p><p><strong>Results: </strong>Uptake values with and without background correction were calculated and intraclass correlation coefficients were highest for uncorrected uptake values (0.97-0.98) followed by those background corrected by subtraction (0.89-0.94) and lowest for those background corrected by division (0.74-0.79).</p><p><strong>Conclusion: </strong>Quantification methods without background correction have the highest inter-reader agreement for <sup>18</sup>F-FDG PET of carotid artery plaque inflammation. The use of the single highest uptake value (max SUV<sub>max</sub>) from the plaque will facilitate the method's clinical utility in stroke prevention.</p>\",\"PeriodicalId\":30457,\"journal\":{\"name\":\"JRSM Cardiovascular Disease\",\"volume\":\" \",\"pages\":\"2048004020980941\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2020-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1177/2048004020980941\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JRSM Cardiovascular Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/2048004020980941\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JRSM Cardiovascular Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/2048004020980941","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Inter-reader agreement of 18F-FDG PET/CT for the quantification of carotid artery plaque inflammation.
Introduction: A significant proportion of ischemic strokes are caused by emboli from unstable atherosclerotic carotid artery plaques. Inflammation is a key feature of plaque instability. Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-(18F)-fluoro-D-glucose (18F-FDG) is a promising technique to quantify plaque inflammation, but a consensus on the methodology has not been established. High inter-reader agreement is essential if 18F-FDG PET/CT is to be used as a clinical tool for the assessment of unstable plaques and stroke risk.
Methods: We assessed the inter-reader variability of different methods for quantification of 18F-FDG uptake in 43 patients with carotid artery stenosis ≥70%. Two independent readers delineated the plaque and collected maximum standardized uptake value (SUVmax) from all axial PET slices containing the atherosclerotic plaque.
Results: Uptake values with and without background correction were calculated and intraclass correlation coefficients were highest for uncorrected uptake values (0.97-0.98) followed by those background corrected by subtraction (0.89-0.94) and lowest for those background corrected by division (0.74-0.79).
Conclusion: Quantification methods without background correction have the highest inter-reader agreement for 18F-FDG PET of carotid artery plaque inflammation. The use of the single highest uptake value (max SUVmax) from the plaque will facilitate the method's clinical utility in stroke prevention.