tBuOK/DMSO/O2催化与苯乙烯的直接α-C（sp3）–H烷基化：氢氨基烷基化的生产性α-氨基†

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2023-01-01 DOI:10.1039/d2qo01911f

Zhangqiang Yan , Zhen Zhang , Tao Wen , Lihua Ye , Bo Jin , Chihong Zhang , Wenkun Wang , Zhong-Ning Chen , Hu Cai

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引用次数: 0

摘要

报道了tBuOK/DMSO/O2催化α-芳基苄胺与苯乙烯直接进行α-C（sp3）-H烷基化反应。该反应在温和的条件下产生了多种选择性取代的胺和N-杂环。机理研究表明，α-氨基烷基作为中间体，氢原子转移（HAT）在tBuOK/DMSO/O2体系中起着至关重要的作用。

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tBuOK/DMSO/O2 catalyzed direct α-C(sp3)–H alkylation with styrenes: productive α-amino radicals for hydroaminoalkylation†

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tBuOK/DMSO/O2 catalyzed direct α-C(sp3)–H alkylation with styrenes: productive α-amino radicals for hydroaminoalkylation†

Direct α-C(sp³)–H alkylation of hydroaminoalkylation (HAA) catalyzed by ^tBuOK/DMSO/O₂ from α-aryl benzylamines with styrenes is reported. The reaction has delivered diverse selectively substituted amines and N-heterocycles under mild conditions. Mechanism studies have shown that α-aminoalkyl radicals act as intermediates and hydrogen atom transfer (HAT) plays a crucial role in the ^tBuOK/DMSO/O₂ system.

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

自引率

0.00%

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